Characterization of coumarins from Ipomoea mauritiana Jacq by LC-APCI-MS/MS analysis and evaluation of its anti-amnesic activity

Abstract

Background Ipomoea mauritiana is one of the source plants of Vidari, an Ayurvedic drug used as Medhyarasayana (rejuvenating drug). In this current study, coumarins were separated from tuberous root of I. mauritiana and characterization of the coumarin fraction was done by LC-MS/MS analysis by atmospheric pressure chemical ionization method. Anti-amnesic activity was evaluated against scopolamine induced amnesia in Wistar rats. Results Mass spectroscopic characterization of coumarin fraction directed to the tentative identification of coumarins such as 7-hydroxy-6-methoxy coumarin, 7-hydroxycoumarin, 5-methoxy-6,7-furanocoumarin, 5,7-dimethoxycoumarin, and 6-hydroxy-7-methoxy-4-phenylcoumarin. Aqueous extract of I. mauritiana at a dose of 100 and 200 mg/kg showed significant anti-amnesic activity against scopolamine-induced changes in step through latency and working memory errors. Conclusion The findings of the study showed that I. mauritiana is a rich source of coumarins and possessed significant anti-amnesic activity. The study concluded the scientific basis of using I. mauritiana as rejuvenating drug in Ayurveda. Graphical abstract

Efficacy of Green Synthesized Nanoparticles in Photodynamic Therapy: A Therapeutic Approach

“…Its composition consists of various phytochemicals, such as taraxerol, taraxerol acetate, β-sitosterol, scopoletin, 7-O-β-D glycopyranosyl scopoletin caffeoyl glucose, and 5-methoxy-6,7-furanocoumarin. Studies suggest that PDT utilizing furanocoumarins may be an effective treatment for autoimmune disorders and skin diseases [ 67 , 68 ]. Scopoletin, one of the phytochemicals of I. mauritiana , is used for the treatment of liver, lungs, skin, and breast cancer.…”