Characterization of cubosomes immobilized in hydrogels of hyaluronic acid and their use for diclofenac controlled delivery

Villalva, Denise Gradella; França, Carla Giometti; Loh, Watson

doi:10.1016/j.colsurfb.2022.112352

Cited by 15 publications

(22 citation statements)

References 38 publications

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“…Villalva et al immobilized cubosomes in oxi-HA/ADH hydrogels and performed rheological studies demonstrating that the presence of both anionic and cationic cubosomes slightly increased the G' values for hydrogels of low and high degrees of cross-linking with respect to their respective pure hydrogels. Therefore, the cubosome charge does not affect the mechanical properties of the hydrogel [118]. These rheological properties confirmed that the in situ applicability of the hydrogel is not affected.…”

Section: Rheologysupporting

confidence: 67%

“…Cubosomes can also be incorporated in hydrogels in order to obtain a better sustained drug delivery system [118,146,147]. In this way, Sanjana et al developed and characterized a novel cubosomal formulation, including dexamethasone (DMS), for vitiligo treatment [146].…”

Section: Topical Drug Delivery and Antimicrobial Therapymentioning

confidence: 99%

“…This hydrogel showed a higher permeation and skin retention, as well as an enhanced anti-fungal activity, being an interesting strategy for topical drug delivery. Villalva et al successfully immobilized diclofenac-loaded cubosomes in oxi-hyaluronic acid/ADH hydrogels, revealing its potential as an important platform for biomedical applications in drug delivery [118].…”

Section: Topical Drug Delivery and Antimicrobial Therapymentioning

confidence: 99%

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A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

et al. 2022

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The impact of nanotechnology on the exponential growth of several research areas, particularly nanomedicine, is undeniable. The ability to deliver active molecules to the desired site could significantly improve the efficiency of medical treatments. One of the nanocarriers developed which has drawn researchers’ attention are cubosomes, which are nanosized dispersions of lipid bicontinuous cubic phases in water, consisting of a lipidic interior and aqueous domains folded in a cubic lattice. They stand out due to their ability to incorporate hydrophobic, hydrophilic, and amphiphilic compounds, their tortuous internal configuration that provides a sustained release, and the capacity to protect and safely deliver molecules. Several approaches can be taken to prepare this structure, as well as different lipids like monoolein or phytantriol. This review paper describes the different methods to prepare nanocarriers. As it is known, the physicochemical properties of nanocarriers are very important, as they influence their pharmacokinetics and their ability to incorporate and deliver active molecules. Therefore, an extensive characterization is essential to obtain the desired effect. As a result, we have extensively described the most common techniques to characterize cubosomes, particularly nanocarriers. The exceptional properties of the cubosomes make them suitable to be used in several applications in the biomedical field, from cancer therapeutics to imaging, which will be described. Taking in consideration the outstanding properties of cubosomes, their application in several research fields is envisaged.

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Section: Rheologysupporting

confidence: 67%

Section: Topical Drug Delivery and Antimicrobial Therapymentioning

confidence: 99%

Section: Topical Drug Delivery and Antimicrobial Therapymentioning

confidence: 99%

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A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

et al. 2022

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“…[17][18][19] Liquid crystalline nanocarriers provide efficient encapsulation of bioactive molecules and improved sustained release features owing to their high surface area of both hydrophilic and hydrophobic domains within the nanoparticles. [20][21][22][23][24][25] These characteristics of the cubosomes are promising for applications in dermal, intravenous, and oral administration, especially for cancer treatments. 7,14,[26][27][28][29][30][31] In the field of oral delivery, cubosomes with the surface modified a Laboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista with polyelectrolyte coatings have been proposed as potential carriers for transport and release of bioactive molecules in the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Interaction of polyelectrolyte-shell cubosomes with serum albumin for triggering drug release in gastrointestinal cancer

et al. 2023

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“…These characteristics are due to the high surface area between the hydrophilic and hydrophobic regions present in its structure. They are composed of a lipid and surfactant/stabilizer, which extends in three dimensions and two nanochannels interwoven, but not connected [ 291 , 292 , 293 ].…”

Section: Other Systems For Voriconazole Deliverymentioning

confidence: 99%

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

et al. 2023

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Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic monitoring, especially in the most severe cases. Voriconazole is an azole widely used to treat invasive aspergillosis, other hyaline molds, many dematiaceous molds, Candida spp., including those resistant to fluconazole, and for infections caused by endemic mycoses, in addition to those that occur in the central nervous system. However, despite its broad activity, using voriconazole has limitations related to its non-linear pharmacokinetics, leading to supratherapeutic doses and increased toxicity according to individual polymorphisms during its metabolism. In this sense, nanotechnology-based drug delivery systems have successfully improved the physicochemical and biological aspects of different classes of drugs, including antifungals. In this review, we highlighted recent work that has applied nanotechnology to deliver voriconazole. These systems allowed increased permeation and deposition of voriconazole in target tissues from a controlled and sustained release in different routes of administration such as ocular, pulmonary, oral, topical, and parenteral. Thus, nanotechnology application aiming to delivery voriconazole becomes a more effective and safer therapeutic alternative in the treatment of fungal infections.

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Characterization of cubosomes immobilized in hydrogels of hyaluronic acid and their use for diclofenac controlled delivery

Cited by 15 publications

References 38 publications

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

Interaction of polyelectrolyte-shell cubosomes with serum albumin for triggering drug release in gastrointestinal cancer

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

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