Characterization of curcumin–PVP solid dispersion obtained by spray drying

Paradkar, Anant; Ambike, Anshuman A.; Jadhav, Bhimrao K; Mahadik, Kakasaheb R.

doi:10.1016/j.ijpharm.2003.11.014

Cited by 302 publications

(157 citation statements)

References 5 publications

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…For the polymers used, all used polymers matched with published data [15,17,21,[23][24][25][26][27][28][29][30]. While it can be observed for that higher molecular weight chitosan (16 kDa) exhibited more spherical shape.…”

Section: Discussionmentioning

confidence: 75%

“…PVP made hydrogen bonding with meloxicam mainly through N-H and C=O groups [26]. Also, SEM analysis proved irregular rounded spherical shape [27].…”

Section: Discussionmentioning

confidence: 95%

“…For FTIR spectra of PVP SDs, there was a disappearance of the three characteristic peaks of meloxicam in the SD of lower meloxicam: PVP ratio. This indicates that PVP and meloxicam have strong hydrogen bonds between them [26,27,31] and precipitation of meloxicam as an amorphous form in PVP prepared SDs. On the other hand, the characteristic peaks of meloxicam appeared in FTIR analysis of PEG SDs confirming its presence as a crystalline form.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Obaidat

Al-Taani

Al-quraan

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: Meloxicam is classified as class II corresponding to its high permeability and low solubility (12μg/ml). This study aims to compare the effect of selected polymers on stabilization of amorphous form, and dissolution of meloxicam by preparation of different solid dispersions using selected polymers (chitosan oligomers, polyvinylpyrrolidone K30, and polyethylene glycols).Methods: These solid dispersions were prepared using two different methods; solvent evaporation method for the two molecular weights chitosan carriers (16 and 11KDa) and polyvinylpyrrolidone-K30 and melting method for the two different molecular weights polyethylene glycol (4000 and 6000). The physicochemical properties of solid dispersions were analyzed using differential scanning calorimetry, Fourier transform infra-red analysis, Powder X-ray diffraction, and scanning electron microscopy. Selected dispersions were then compared to two selected marketed drugs (Mobic® and Moven®).Results: Best dissolution rates were obtained for both polyvinylpyrrolidone-K30 and polyethylene glycol 6000, followed by chitosan 16 kDa, chitosan 11 kDa, and polyethylene glycol 4000. Increasing polymeric ratio increased dissolution rate except for chitosan. Precipitation of the drug as amorphous form occurred in chitosan and polyvinylpyrrolidone-K30 dispersions, while no change in crystallinity obtained for polyethylene glycol dispersions. Failure of polyvinylpyrrolidone-K30 in the maintenance of stability during storage time was observed while re-crystallization occurred in chitosan-based dispersions, which ends with preferences to polyethylene glycol dispersions. After comparing the release of selected dispersions with the two selected polymers; all dispersions got a higher release than that of the two marketed drugs release. Conclusion:The dissolution profile of meloxicam has been increased successfully in a reproducible manner.

show abstract

Section: Discussionmentioning

confidence: 75%

“…PVP made hydrogen bonding with meloxicam mainly through N-H and C=O groups [26]. Also, SEM analysis proved irregular rounded spherical shape [27].…”

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Obaidat

Al-Taani

Al-quraan

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

“…DRS spectra of Pravastatin sodium (a), Eudragit S100 (b), physical mixture of pravastatin sodium and Eudragit S100 (c), and F6 (d) liquid state (23) during microsphere formation. The reduction in the intensity of peaks in microparticles is attributable to higher concentration of polymer and conversion of crystalline form of the drug to its amorphous form (24). The DSC thermograms did not indicate any interaction between the drug and excipients that was further confirmed by diffuse reflectance spectroscopy.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 77%

Design and In Vitro Performance Evaluation of Purified Microparticles of Pravastatin Sodium for Intestinal Delivery

Garg

Pathak

2011

AAPS PharmSciTech

View full text Add to dashboard Cite

Abstract. The purpose of research was to develop a mucoadhesive multiparticulate sustained drug delivery system of pravastatin sodium, a highly water-soluble and poorly bioavailable drug, unstable at gastric pH. Mucoadhesive microparticles were formulated using eudragit S100 and ethyl cellulose as mucoadhesive polymers. End-step modification of w/o/o double emulsion solvent diffusion method was attempted to improve the purity of the product, that can affect the dose calculations of sustained release formulations and hence bioavailability. Microparticles formed were discrete, free flowing, and exhibited good mucoadhesive properties. DSC and DRS showed stable character of drug in microparticles and absence of drug polymer interaction. The drug to polymer ratio and surfactant concentration had significant effect on mean particle size, drug release, and entrapment efficiency. Microparticles made with drug: eudragit S100 ratio of 1:3 (F6) exhibited maximum entrapment efficiency of 72.7% and ex vivo mucoadhesion time of 4.15 h. In vitro permeation studies on goat intestinal mucosa demonstrated a flux rate (1,243 μg/cm 2 /h) that was 169 times higher than the flux of pure drug. The gastric instability problem was overcome by formulating the optimized microparticles as enteric-coated capsules that provided a sustained delivery of the highly water-soluble drug for 12 h beyond the gastric region. The release mechanism was identified as fickian diffusion (n=0.4137) for the optimized formulation F6. Conclusively, a drug delivery system was successfully developed that showed delayed and sustained release up to 12 h and could be potentially useful to overcome poor bioavailability problems associated with pravastatin sodium.

show abstract

“…Extensive research within the last half century has proven that most of these pharmacological activities associated with turmeric are due to active ingredient curcumin. Ethno-botanically curcumin has been proven as a potent compound which act as an antioxidant and anticancer in both man and animals 7 . It has been reported that these effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes 8 .…”

Section: Ethnobotanical Usesmentioning

confidence: 99%

Untitled

2017

IJPSR

View full text Add to dashboard Cite

Purpose: To prepare and evaluate floating tablet of curcumin for prolonged gastric residence time and increased drug bioavailability for the treatment of gastric problem. Methods: Floating tablet were prepared by wet granulation method using different ratios of Curcumin, Psyllium husk, HPMC K 15 M, HPMC K 100 M and Mangifera indica gum. The respective powders were blended thoroughly and a dump mass was prepared by adding the granulating agent. Dump mass was passed through sieve number 10 and dried in hot air oven at 50 0 C for 30 mins. After drying, granules were further passed through sieve number 22 to attain the uniformity in granules. Finally, optional additives like magnesium stearate and talc were added and finely blended for preparation of floating tablet. Result: Floating drug delivery tablets were being formulated and the present study focused on the formulation of FDDS by using different polymes like phyllium husk, HPMC K 100 and HPMC K15 and to evaluate its efficacy in reducing ulcers caused by H.pylori. The Floating drug delivery tablets were characterized for their weight variation, hardness, friability, drug content determination, disintegration, in-vitro dissolution studies, IR, floating lag time, swelling studies and erosion studies. Conclusion: The developed curcumin floating tablet system is a promising floating drug delivery system for oral sustained administration of curcumin.

show abstract

Characterization of curcumin–PVP solid dispersion obtained by spray drying

Cited by 302 publications

References 5 publications

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Design and In Vitro Performance Evaluation of Purified Microparticles of Pravastatin Sodium for Intestinal Delivery

Untitled

Contact Info

Product

Resources

About