Characterization of Curcuminoid  from Curcuma xanthorrhiza and Its Activity Test as Antioxidant and Antibacterial

Atun, Sri; Aznam, Nurfina; Arianingrum, Retno; Senam, Senam; Naila, Bian Ihda An; Lestari, Astuti; Purnamaningsih, Nur Aini

doi:10.20884/1.jm.2020.15.2.540

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…In addition, C. xanthorrhiza it is also used as an ingredient in jamu (Indonesian herbal supplements and medicines). Several studies reported the pharmacological activity of C. xanthorrhiza namely as anticancer (Indrayanti et al 2021), antimicrobial (Akarchariya et al 2017), anti-inflammatory (Devaraj et al 2010), antitumor (Rahmat et al 2021), antibacterial (Atun et al 2020), antihypertensive (Campos et al 2008;Oon et al 2015), antihyperglycemic (Kim et al 2014), nephroprotective (Kim et al 2005), and antioxidant activities (Rosidi et al 2016). The active compounds influence this pharmacological effect in the rhizome of Curcuma xanthorrhiza Roxb, namely curcuminoid, which also gives a yellowish-orange color to the rhizome of C. xanthorrhiza (Erpina et al 2017) and xanthorrhizol which belongs to the sesquiterpenoid class (Susanto et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Total phenolic and flavonoid contents and their antioxidant capacity of Curcuma xanthorrhiza accessions from Jambi

ASYHAR,

MINARNI,

ARISTA

et al. 2023

Biodiversitas

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Abstract. Asyhar R, Minarni M, Arista RA, Nurcholis W. 2023. Total phenolic and flavonoid contents and their antioxidant capacity of Curcuma xanthorrhiza accessions from Jambi. Biodiversitas 24: 5007-5014. Curcuma xanthorrhiza Roxb., is an effective natural antioxidant and is widely used as a raw material for jamu in Indonesian traditional medicine. This study aims to evaluate the biochemical characteristics and antioxidant capacity of C. xanthorrhiza rhizome accessions. Ten accessions of C. xanthorrhiza rhizome from 10 districts in Jambi province were evaluated for total phenolic (TPC) and total flavonoid (TFC) content and antioxidant capacity using four methods: 2,2-diphenyl picrylhydrazyl (DPPH), 2,2 azinobis (3-ethyl benzothiazoline) -6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant power (CUPRAC). The content of total phenolic (TPC) and total flavonoids (TFC) varied from 1.74±0.085 to 18.72±1.47 mg GAE/g DW and 1.74±0.085 to 18.72±1.47 mg GAE/g DW, respectively. Antioxidant capacities ranged from 0.13-1.11, 0.72-4.14, 7.71-81.48, 18.37-211.68 µmol TE/g DW, assayed by DPPH, ABTS, FRAP, and CUPRAC methods, respectively. Antioxidant activity was significantly correlated with the polyphenol content of C. xanthorrhiza rhizome accessions. Accession to C. xanthorrhiza rhizome with the code JSS, JBE, JG, and JK has the capacity for polyphenolic compounds (phenolics and flavonoids) and antioxidant capacity compared to other accessions, indicating that these accessions are promising for further breeding programs and commercial purposes.

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Section: Introductionmentioning

confidence: 99%

Total phenolic and flavonoid contents and their antioxidant capacity of Curcuma xanthorrhiza accessions from Jambi

ASYHAR,

MINARNI,

ARISTA

et al. 2023

Biodiversitas

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“…is a medicinal plant of the rhizome family (Zingiberaceae), a popular ingredient used for seasoning and medicine. Curcuma contains curcuminoid fraction yield at the level of 10.06% from the ethanol extract (Atun et al, 2020), which generates a yellow color in the rhizome and exhibits several properties, such as antibacterial, anticancer, antitumor, and antiinflammation, as well as antioxidant and hypocholesterolemia (Lee et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Egg Production, Egg Quality, and Fatty Acid Profile of Indonesian Local Ducks Fed with Turmeric, Curcuma, and Probiotic Supplementation

Ismoyowati¹,

Indrasanti

Ratriyanto

et al. 2022

Trop. Anim. Sci. J.

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Indonesian local ducks are commonly raised for egg production purposes. However, the performances of these ducks are still variable and must be improved. This study investigated the effects of turmeric, curcuma, and probiotic supplementations on the egg production and quality of Indonesian local ducks, emphasizing the eggs' fatty acid profile. Two hundred female local ducks aged 16 weeks were randomly allotted to four dietary treatments with five replicates of 10 birds. The ducks were fed a corn and rice bran-based diet containing different supplements, i.e., a diet without supplementation as the control diet, a diet supplemented with turmeric at the level of 4%, a diet supplemented with curcuma at the level of 4%, and a diet supplemented with starbio probiotics at the level of 2%. The measured data were analyzed using analysis of variance using the 13 Systat program and continued with Duncan's Multiple Range Test. Turmeric supplementation increased egg production compared with the control, and the duck fed probiotics consumed more feed than the control. Curcuma supplementation generated the lowest feed consumption, egg production, and physical egg quality than the other treatments (p<0.05). The probiotics supplementation enhanced the blood high-density lipoprotein concentration (p<0.05). Turmeric, curcuma, and probiotics supplementations generate variable responses in egg production and egg quality, including the fatty acid profile in the eggs. Turmeric and probiotics supplementations positively impact egg production, egg quality, or unsaturated fatty acid profile in the egg. However, curcuma supplementation decreased egg production and egg quality of local ducks. Furthermore, the fatty acid profile was not influenced by these supplements. It is concluded that supplementation of turmeric at the level of 4% and probiotics at the level of 2% in the diet can increase egg production and egg quality of local duck.

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“…C. xanthorrhiza is often used in combination with other medicinal plants to form a mixture of herbal products to increase stamina and immunity. [ 1 ] The potential pharmacological activities of C. xanhtorrhiza include antibacterial, antioxidant,[ 2 ] anti-inflammatory, anticancer,[ 3 ] antihypertensivity, and immunomodulatory activity. [ 4 ] The phytochemical profile obtained from various literature indicate the presence of xanthorrhizol compounds, which are typical compounds of C. xanthorrhiza , amino acids, carbohydrates, curcuminoid compounds such as octahydrocurcumin, curcumin, dihydrocurcumin, and hexahydrocurcumin,[ 1 , 5 ] and vanillin compounds[ 6 ] such as isoborneol, camphor, and trans-caryophyllene.…”

Section: Introductionmentioning

confidence: 99%

Optimized Solvents for the Maceration of Phenolic Antioxidants from Curcuma xanthorrhiza Rhizome using a Simplex Centroid Design

Nurcholis¹,

Marliani²,

Asyhar³

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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A BSTRACT Background: Curcuma xanthorrhiza Roxb., from the Zingiberaceae family, is a famous plant native to Indonesia that is highly effective in treating diseases due to the various chemical compounds it contains. Objective: This study aims to optimize the extraction process for the phenolic content, with its antioxidant activity, from the rhizome of C. xanthorrhiza using different solvent (water, acetone, methanol, and ethanol) systems based on the simplex centroid design using the Design Expert 13.0 program. Methods and Material: Total phenolic content (TPC) was analyzed by colorimetry using Follin–Ciocalteu, while the antioxidant activity was measured based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) using a spectrophotometer. Results: To measure TPC and DPPH, a special cubic model was used; to measure FRAP, a linear model was utilized. Each model demonstrated a good match with the R 2 values for TPC (0.9808), DPPH (0.9583), and FRAP (0.7872). The combination of a mixture of water (0.409), acetone (0.307), and methanol (0.284) with a desirability level of 0.723, resulted in a TPC of 34.112 mg gallic acid equivalent (GAE)/g dry weight (DW), DPPH of 26.533 μmol Trolox equivalent (TE)/g DW, and FRAP of 92.353 μmol TE/g DW. This showed a high extraction efficiency which was optimal. Conclusions: The best condition to extract the rhizomes of C. xanthorrhiza was a ternary combination of solvents including water, acetone, and methanol in the proportions of 0.409, 0.307, and 0.284, respectively, with a desirability level of 0.723.

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Characterization of Curcuminoid from Curcuma xanthorrhiza and Its Activity Test as Antioxidant and Antibacterial

Cited by 6 publications

References 19 publications

Total phenolic and flavonoid contents and their antioxidant capacity of Curcuma xanthorrhiza accessions from Jambi

Total phenolic and flavonoid contents and their antioxidant capacity of Curcuma xanthorrhiza accessions from Jambi

Egg Production, Egg Quality, and Fatty Acid Profile of Indonesian Local Ducks Fed with Turmeric, Curcuma, and Probiotic Supplementation

Optimized Solvents for the Maceration of Phenolic Antioxidants from Curcuma xanthorrhiza Rhizome using a Simplex Centroid Design

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