Characterization of Cytochalasins and Steroids From the Ascomycete <i>Daldinia concentrica</i> and Their Cytotoxicity

Trung, Hoang Van; Kuo, Ping Chung; Tuấn, Nguyễn Ngọc; Ngân, Nguyễn Thị Thanh; Trung, Nguyen Quang; Thanh, Nguyen Tan; Hai, Ha Viet; Phuong, Doan Lan; Bach, Long Giang; Li, Yue Chiun; Wu, Tian Shung; Thăng, Trân Đình

doi:10.1177/1934578x19846320

Cited by 6 publications

(9 citation statements)

References 19 publications

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“…In 2019, a novel cytochalasan from fruiting bodies of Daldinia concentrica was isolated and named daldinin (55), along with two known ones [83]. Assessment of the cytotoxic activities showed that 55 exhibited weak cytotoxic activity against several cell lines like SK-LU-1 or MCF-7 with IC 50 values of 11.4 and 13.5 µM, respectively.…”

Section: Benzenoids and Lactones From Xylariaceae (Fig 7)mentioning

confidence: 99%

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Becker

Stadler

2020

J Antibiot

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The families Xylariaceae and Hypoxylaceae (Xylariales, Ascomycota) represent one of the most prolific lineages of secondary metabolite producers. Like many other fungal taxa, they exhibit their highest diversity in the tropics. The stromata as well as the mycelial cultures of these fungi (the latter of which are frequently being isolated as endophytes of seed plants) have given rise to the discovery of many unprecedented secondary metabolites. Some of those served as lead compounds for development of pharmaceuticals and agrochemicals. Recently, the endophytic Xylariales have also come in the focus of biological control, since some of their species show strong antagonistic effects against fungal and other pathogens. New compounds, including volatiles as well as nonvolatiles, are steadily being discovered from these ascomycetes, and polythetic taxonomy now allows for elucidation of the life cycle of the endophytes for the first time. Moreover, recently high-quality genome sequences of some strains have become available, which facilitates phylogenomic studies as well as the elucidation of the biosynthetic gene clusters (BGC) as a starting point for synthetic biotechnology approaches. In this review, we summarize recent findings, focusing on the publications of the past 3 years.

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Section: Benzenoids and Lactones From Xylariaceae (Fig 7)mentioning

confidence: 99%

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Becker

Stadler

2020

J Antibiot

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“…Menurut Yuyama et al (2013), Daldinia memiliki karakteristik utama yaitu terdapat formasi belang hitam pada stromata dengan diameter yang bervariasi antar individu spesies. Trung et al (2019) menyebutkan bahwa Daldinia merupakan jamur yang berpotensi menjadi sumber obat sehubungan dengan kandungan senyawa bioaktif yang merupakan metabolit sekundernya. Selain itu, menurut Debnath et al (2019), bubuk dari tubuh buah Daldinia dapat digunakan sebagai obat luka bakar, gatal, dan beberapa infeksi kulit lainnya.…”

Section: Pembahasanunclassified

Catatan Diversitas Jamur di Salah Satu Pulau Terluar Republik Indonesia

Nurdiyanti

Suharti

Amelya

et al. 2020

JSDH

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Marore Island (Province of North Sulawesi) is one of the outermost island in Indonesia. The island is located at the borderline within the Philippines. Till date, there is no publication about islands macrofungi diversity from this island. In fact, the diversity of macrofungi has the potency to support the development of global bioeconomic in Indonesia. The purpose of this study is to make an inventory list of macrofungi on Marore Island in order to enhance the potential in the future. A total was of 22 mushrooms from 13 genera were obtained from this study which were divided into two phylums, namely Basidiomycota and Ascomycota. The identification results confirmed the species obtained: Ganoderma sp.1, Ganoderma sp.2, Ganoderma sp.3, Ganoderma sp.4, Ganoderma sp.5, Ganoderma sp.6, Trametes sp.1, Trametes sp.2, Trametes sp.3, Pycnoporus sp.1, Pycnoporus sp.2, Polyporus sp., Daedalea sp., Lentinus sp., Marasmius sp.1, Marasmius sp.2, Schizophyllum sp., Panellus sp., Tricholoma sp., Phallus sp., Dacryopinax spathularia, and Daldinia sp.

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“…Oleic acidhave antiinflamatory, antiandrogenic, cancer preventive, dermatigenic, hypocholesterolemic, anemiagenic, insectifuge activity 26 . Toxicity study of D. concentrica solvent extracts has also been carried out on human tumour cell line and animal model [27][28] . Some other compounds were also identified in GC-MS analysis, which may have notable biological activity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antibacterial Potential of Daldinia concentrica from North Eastern Region of India

et al. 2020

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Morphological, bio-chemical and antibacterial potential of an ascomycetous fungus, Daldinia concentrica, was evaluated. It was collected from dead, decaying log of Mimusops elengi tree and isolated by plating in potato dextrose medium. Macroscopic and microscopic features of the stromata were studied. The crude methanol extract of the stromata (30 mg/ml) exhibited significant antibacterial activity against Escherichia coli (MTCC-40), Pseudomonas aeruginosa (MTCC-7093), Klebsiella pneumoniae (MTCC-661), Enterobacter aerogenes (MTCC-111) and Gram positive bacteria Staphylococcus aureus (MTCC-7443), Bacillus subtilis (MTCC-121). Bacillus subtilis was the most sensitive organism to the methanol extract of this fungus with 41.33 mm zone of inhibition. Gas Chromatographic–Mass Spectral Analysis of stromatal methanol extract revealed the presence of 19 compounds. The present investigation indicated the potential antibacterial activity of native D. concentrica, which could be useful for pharmaceutical application.

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Characterization of Cytochalasins and Steroids From the Ascomycete Daldinia concentrica and Their Cytotoxicity

Cited by 6 publications

References 19 publications

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Catatan Diversitas Jamur di Salah Satu Pulau Terluar Republik Indonesia

Evaluation of Antibacterial Potential of Daldinia concentrica from North Eastern Region of India

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