Characterization of degradation products resulted from acidic hydrolysis of lisinopril under drastic conditions

Abstract

Objective: Characterization and structure elucidation of the degradation products which resulted from the acidic hydrolysis of lisinopril under drastic condition. Method: Ultra-performance liquid chromatography coupled with mass/mass spectroscopy (LC-MS/MS) with simple and sensitive method was used to detect the formed degradation products. The fragmentation patterns of the degradation products were investigated. Results: The validation of analytical method was satisfied to the recommend criteria of international conference of harmonization. Four degradation products were formed due to the acidic hydrolysis of lisinopril. Conclusion: Two degradation products were described in E. Ph.