Characterization of digital waveforms using thermodynamic analogs: applications to detection of materials defects

Hughes, Michael S.; Marsh, Jon N.; Hall, Christopher S.; Savery, David; Lanza, Gregory M.; Wickline, Samuel A.

doi:10.1109/tuffc.2005.1516028

Cited by 24 publications

(24 citation statements)

References 16 publications

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“…(2)). The defect-to-defect-free region contrast for the A4000 specimen is much higher than that of the resin-rich specimen which is consistent with observations of previous studies which demonstrated [9] that the A4000 inclusion was the easiest to detect. The histogram (not shown) of the pixel values in this image shows two widely separated peaks.…”

Section: Resultssupporting

confidence: 91%

“…We have also repeated, on the image in the fifth row, the contrast ratio analysis described in an earlier study. [9] The contrast ratio is -3.8 vs. at best 1.5 reported in the bottom row of Figure 6 contained in the earlier report. Thus, in addition to being better understood, the joint entropy analysis provides improved contrast to that obtained using the thermodynamic analysis.…”

Section: Resultsmentioning

confidence: 61%

“…[9]. One of these, designated as the A4000 specimen has also been subjected to the same type of optimization search as was the resin-rich specimen.…”

Section: Resultsmentioning

confidence: 99%

“…Since this study focuses on a subset of data from a much larger study which was previously published [9] we briefly summarize the acquisition of data used for this study. The basic morphology of the specimen is shown in Fig.…”

Section: Data Acquisitionmentioning

confidence: 99%

“…These include detection of unresolvable near-surface defects [5,6,7,8,9,4], diffuse accumulation of subresolution-sized nanoparticle-based ultrasound contrast agents[1, 10,11,12,13], characterization of smooth muscle pathologies [14,15], and monitoring of ultrasonically induced temperature rise in tissue. [16] FIGURE 1.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

High contrast ultrasonic imaging of resin-rich regions in graphite/epoxy composites using entropy

Hughes¹,

McCarthy²,

Bruillard³

et al. 2016

AIP Conference Proceedings

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 61%

“…[9]. One of these, designated as the A4000 specimen has also been subjected to the same type of optimization search as was the resin-rich specimen.…”

Section: Resultsmentioning

confidence: 99%

Section: Data Acquisitionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

High contrast ultrasonic imaging of resin-rich regions in graphite/epoxy composites using entropy

Hughes¹,

McCarthy²,

Bruillard³

et al. 2016

AIP Conference Proceedings

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FromIn VivoUltrasound andMRIImaging to Therapy: Contrast Agents Based on Target‐Specific Nanoparticles

Wallace¹,

Hughes²,

Marsh³

et al. 2010

Nanotechnology

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Molecular imaging utilizes a novel toolset to enable and expand the role of noninvasive diagnostic imaging from the realm of gross anatomical description to the identification of specific tissue epitopes and observation of biological processes at the cellular level. Until recently, this approach was confined to the field of nuclear imaging; however, advances in nanotechnology have extended this research to include imaging modalities such as ultrasound and magnetic resonance imaging. The application of nanotechnology to magnetic resonance and ultrasound molecular imaging has generated several candidate contrast agents. One multimodality platform – targeted perfluorocarbon nanoparticles – is useful for noninvasive detection with all three imaging modalities, and may additionally be used for local drug delivery.

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Anti‐angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis

Caruthers

Cyrus

Winter

et al. 2009

WIREs Nanomed Nanobiotechnol

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Complementary developments in nanotechnology, genomics, proteomics, molecular biology and imaging offer the potential for early, accurate diagnosis. Molecularly-targeted diagnostic imaging agents will allow noninvasive phenotypic characterization of pathologies and, therefore, tailored treatment close to the onset. For atherosclerosis, this includes anti-angiogenic therapy with specifically-targeted drug delivery systems to arrest the development of plaques before they impinge upon the lumen. Additionally, monitoring the application and effects of this targeted therapy in a serial fashion will be important. This review covers the specific application of alpha(nu)beta(3)-targeted anti-angiogenic perfluorocarbon nanoparticles in (1) the detection of molecular markers for atherosclerosis, (2) the immediate verification of drug delivery with image-based prediction of therapy outcomes, and (3) the serial, noninvasive observation of therapeutic efficacy.

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Characterization of digital waveforms using thermodynamic analogs: applications to detection of materials defects

Cited by 24 publications

References 16 publications

High contrast ultrasonic imaging of resin-rich regions in graphite/epoxy composites using entropy

High contrast ultrasonic imaging of resin-rich regions in graphite/epoxy composites using entropy

FromIn VivoUltrasound andMRIImaging to Therapy: Contrast Agents Based on Target‐Specific Nanoparticles

Anti‐angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis

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