Characterization of Disopyramide derivative ADD424042 as a non-cardiotoxic neuronal sodium channel blocker with broad-spectrum anticonvulsant activity in rodent seizure models

Król, Marek; Ufnal, Marcin; Szulczyk, Bartłomiej; Podsadni, Piotr; Drapała, Adrian; Turło, Jadwiga; Dawidowski, Maciej

doi:10.1016/j.ejps.2015.10.002

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…A number of studies have shown that cardiotoxic drugs prolong QT interval in rodents, and ECG recording in rats has been used as a screening tool in cardiotoxicity studies (Hanada et al 1999, Ohtani et al 1996, Król et al 2016. However, it needs to be stressed that the translation of the results of those studies to humans has limitations.…”

Section: Qt Intervalmentioning

confidence: 99%

Electrocardiography in Rats: a Comparison to Human

2016

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Electrocardiography (ECG) in rats is a widely applied experimental method in basic cardiovascular research. The technique of ECG recordings is simple; however, the interpretation of electrocardiographic parameters is challenging. This is because the analysis may be biased by experimental settings, such as the type of anesthesia, the strain or age of animals. Here, we aimed to review electrocardiographic parameters in rats, their normal range, as well as the effect of experimental settings on the parameters variation. Furthermore, differences and similarities between rat and human ECG are discussed in the context of translational cardiovascular research.There are several invasive and non-invasive techniques that allow 1 to 12 channel ECG recordings in laboratory animals. Most studies use a limb lead II that is https: //doi.org/10.33549/physiolres.933270

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Section: Qt Intervalmentioning

confidence: 99%

Electrocardiography in Rats: a Comparison to Human

2016

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“…From the result obtained in this study, severe hypotension associated with Isoproterenol-induced myocardial injury can be linked with cardiac output and peripheral resistance alteration. The cardiac output was altered, probably due to increased myocardial oxygen consumption arising from larger dose of Isoproterenol which possess higher affinity for β 1 and β 2 receptor of the myocardial tissue [36] leading to imbalance between cardiac muscle workload and oxygen supply [37]. This is associated with tachycardia, thereby reducing the ventricular filling time of the diastolic phase during cardiac cycle, leading to low stroke volume/ejection fraction and reduced cardiac output.…”

Section: Discussionmentioning

confidence: 99%

Corchorus olitorius Extract Attenuate Isoproterenol-Induced Cardiac Injury via Inhibition of Oxidative Stress, Arrhythmia and Pro-Apoptotic Protein Bax Expression

Alabi

Omóbòwálé

Oyagbemi

et al. 2020

JOCAMR

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Background and Aim: Corchorus olitorius (CO) leaf was reported to possess abundant antioxidants and used in the traditional treatment of heart disease. Previous studies revealed the protective roles of antioxidants against oxidative stress and inflammation, which are important underlying pathogenesis of myocardial injury that leads to infarction and heart failure. Therefore, CO leaf was chosen to evaluate its cardio-protective effects against ischemic-induced myocardial injury. Materials and Methods: Thirty male rats (Wistar strains) were divided into five groups (n = 6): normal control group, myocardial injury control group, pretreatment groups (250 and 500 mg/kg), positive control group (10 mg/kg enalapril). After pre-treatment of rats with ethanol leaf extract of CO for 19 days, Isoprenaline (100 mg/kg) administration induced acute myocardial injury and parameters like blood pressure, electrocardiogram, lipid peroxidation, antioxidants were assessed and tissue subjected to histological evaluations. Results: Isoproterenol given through subcutaneous significantly (p<0.05) reduced blood pressure and electrocardiography showed reduced p-interval and prolongation of QRS-interval in rats. The extract significantly increased the blood pressure and p-interval, QRS-interval were significantly reduced. The significant increase in tissue malondialdehyde, serum myeloperoxidase, creatine kinase-MB, lactate dehydrogenase and expression of Bax in the infarction control rats was decreased (p<0.05) in pre-treatment rats. Pre-treatment also increased glutathione-s-transferase, reduced glutathione and non-protein thiol level significantly. In contrast to cardio-injury control, histology showed mild level of inflammation and fatty infiltration in pre-treated rats. Conclusion: This study showed the protective role of ethanol extract of CO against myocardial injury through anti-apoptotic, antioxidant, anti-inflammatory and anti-arrhythmic effect.

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Valproic acid inhibits TTX-resistant sodium currents in prefrontal cortex pyramidal neurons

Szulczyk

Nurowska

2017

Biochemical and Biophysical Research Communications

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Characterization of Disopyramide derivative ADD424042 as a non-cardiotoxic neuronal sodium channel blocker with broad-spectrum anticonvulsant activity in rodent seizure models

Cited by 8 publications

References 42 publications

Electrocardiography in Rats: a Comparison to Human

Electrocardiography in Rats: a Comparison to Human

Corchorus olitorius Extract Attenuate Isoproterenol-Induced Cardiac Injury via Inhibition of Oxidative Stress, Arrhythmia and Pro-Apoptotic Protein Bax Expression

Valproic acid inhibits TTX-resistant sodium currents in prefrontal cortex pyramidal neurons

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