Nano Based Drug Delivery 2015

DOI: 10.5599/obp.8.4

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Characterization of drug-loaded nanoparticles

Irina Kalashnikova¹,

Norah A. Albekairi²,

Sanaalarab Al-Enazy³

et al.

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Z-potential1

Drug Release1

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Cited by 4 publications

(2 citation statements)

References 107 publications

(145 reference statements)

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“…Details regarding the equations relating drug loading and encapsulation efficiency have been published previously [21].…”

Section: Z-potentialmentioning

confidence: 99%

“…Release of digoxin from the nanoparticles was studied under sink conditions in phosphate buffered saline (PBS) at 37°C as described previously [21,22]. In vitro drug release profiles in PBS have been previously shown to correlate well with the kinetics of in vivo therapeutic effects [18].…”

Section: Drug Releasementioning

confidence: 99%

See 1 more Smart Citation

Transport of digoxin-loaded Polymeric Nanoparticles Across BeWo cells, an In Vitro Model of Human Placental Trophoblast

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³

et al. 2015

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Background: Fetal arrhythmias can lead to fetal congestive heart failure and hydrops fetalis. Digoxin (the first-line treatment) has low transplacental permeability and high risk of maternal side effects. Biodegradable digoxin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles may increase digoxin transport across BeWo b30 cell monolayers (an in vitro model of trophoblast in human placenta) by reducing the drug's interaction with P-gp. Results/methodology: The nanoparticles showed high encapsulation efficiency and sustained release over 48 h. Transport studies revealed significantly increased permeability across BeWo cell layers of digoxin-loaded nanoparticles when compared with free digoxin. P-gp inhibition also increased the permeability of digoxin, but not digoxin-loaded nanoparticles. Conclusion: This represents a novel treatment strategy for fetal cardiovascular disease which may improve maternal and fetal outcomes.

“…Details regarding the equations relating drug loading and encapsulation efficiency have been published previously [21].…”

Section: Z-potentialmentioning

confidence: 99%

“…Release of digoxin from the nanoparticles was studied under sink conditions in phosphate buffered saline (PBS) at 37°C as described previously [21,22]. In vitro drug release profiles in PBS have been previously shown to correlate well with the kinetics of in vivo therapeutic effects [18].…”

Section: Drug Releasementioning

confidence: 99%

Transport of digoxin-loaded Polymeric Nanoparticles Across BeWo cells, an In Vitro Model of Human Placental Trophoblast

¹

,

²

,

³

et al. 2015

Self Cite

View full text Add to dashboard Cite

Background: Fetal arrhythmias can lead to fetal congestive heart failure and hydrops fetalis. Digoxin (the first-line treatment) has low transplacental permeability and high risk of maternal side effects. Biodegradable digoxin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles may increase digoxin transport across BeWo b30 cell monolayers (an in vitro model of trophoblast in human placenta) by reducing the drug's interaction with P-gp. Results/methodology: The nanoparticles showed high encapsulation efficiency and sustained release over 48 h. Transport studies revealed significantly increased permeability across BeWo cell layers of digoxin-loaded nanoparticles when compared with free digoxin. P-gp inhibition also increased the permeability of digoxin, but not digoxin-loaded nanoparticles. Conclusion: This represents a novel treatment strategy for fetal cardiovascular disease which may improve maternal and fetal outcomes.

PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model

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³

et al. 2023

Journal of Pharmaceutical Sciences

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Development of tumor-specific liposomes containing quantum dots-photosensitizer conjugate used for radiotherapy

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³

et al. 2022

Journal of Liposome Research

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No abstract

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