Characterization of Dry Powder Inhaler Quercetin Solid Lipid Microparticle (Slm) as Lung Deliverysystem: Effect of Polymer Concentration

Hariyadi, Dewi Melani; Prestisya, Iqlima; Suhariyono, Gatot; Miatmoko, Andangndang; Rosita, Noorma; Rahmadi, Mahardian

doi:10.21608/ejchem.2022.120170.5393

Cited by 3 publications

(10 citation statements)

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“…Moreover, employing glyceryl behenate as a lipidic component and poloxamer 188 as a surfactant molecule, Hariyadi and colleagues manufactured a solid lipid microparticle system encapsulating quercetin. Reduced poloxamer concentrations resulted in burst releases of quercetin, while higher surfactant concentrations resulted in a prolonged and controlled release profile [ 85 ]. Furthermore, quercetin-incorporated liposomes fabricated by Tefas and colleagues demonstrated that DPPC (Di palmitoyl phosphatidyl choline) level and lipid ratio were the primary determinants of particle size.…”

Section: Natural Bioactive Compounds In Lipid-based Drug Delivery Sys...mentioning

confidence: 99%

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Patel,

Garala,

Singh

et al. 2024

Pharmaceuticals

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In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action limited their pharmaceutical applications. However, those can be improved using nanotechnology to create various drug delivery systems, including lipid-based nanoparticles, to adjust the compounds’ physicochemical properties and pharmacokinetic profile. Because of the enormous technical advancements made in the fundamental sciences and the physical and chemical manipulation of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon in research and development for overcoming restrictions, including traditional medication administration systems. Nanotechnology-driven bioactive compounds are certain to have a high impact and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver a range of naturally occurring bioactive compounds with decent entrapment potential and stability, a successfully controlled release, increased bioavailability, and intriguing therapeutic activity. This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation and clinical considerations.

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Section: Natural Bioactive Compounds In Lipid-based Drug Delivery Sys...mentioning

confidence: 99%

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Patel,

Garala,

Singh

et al. 2024

Pharmaceuticals

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“…Glyceryl Behenate Showed significantly superior effectiveness (Chakraborty et al, 2017) ; compared to conventional antihistamine (Rosita et al, 2022) ; medications; spherical with smooth surfaces, (Hariyadi et al, 2022) demonstrated good flowability; prolonging quercetin release duration Chitosan-Promising potential for wound dressings and (Zhou et al, 2021) ; Polycaprolactone medication delivery carriers in wound management; (Azeem et al, 2022) ; synergistic antibacterial and antioxidant capabilities (Viscusi et al, 2023) have a 30-month shelf life; the delayed release of quercetin in an acidic environment Chitosan Superior therapeutic effects in rabbit colitis models; (Helmy et al, 2020) ; effective approach for developing antibiotic (Wiggers et al, 2022) ; -releasing coatings for medical purposes; the (Azeem et al, 2023) bactericidal activity has been improved.…”

Section: Inulin-chitosanmentioning

confidence: 99%

“…Hot-melt extrusion (Khor et al, 2017) Chitosan-Fluorescein Oxidative degradation and ionic (Zhou et al, 2022) ; Isothiocyanate-Zein cross-linking; coacervation (Al-Musawi et al, 2023) ; (Elmowafy et al, 2023) Sodium Alginate Aerosolization ionic gelation (Kalalo et al, 2022) ; (Xu et al, 2023) ; (Szulc Musioł et al, 2023) Inulin-Chitosan-Emulsion-assisted gelation, ionic gelation (Nalini et al, 2019) ; Sodium Alginate (Liu et al, 2022) ; (Liu et al, 2023) Glyceryl Behenate Emulsification (Chakraborty et al, 2017) ; (Rosita et al, 2022) ; (Hariyadi et al, 2022) Chitosan-Polycaprolactone Ultra-homogenization (Zhou et al, 2021) ; (Azeem et al, 2022) ; (Viscusi et al, 2023) Chitosan Ionic cross-linking (Helmy et al, 2020) ; (Wiggers et al, 2022) ; (Azeem et al, 2023) Chitosan-Alumina-Double oil in water emulsification; (Liu et al, 2017) ; PLGA-Oleic Acid gelation ionic and spray drying (Lee et al, 2018) ; (Nematollahi et al, 2021) Alginate-Hydroxyapatite Gelation method; electrostatic (Malvano et al, 2021) ; microencapsulation (Kim et al, 2022) ; (Montone et al, 2023) Eudragit S100…”

Section: Starchmentioning

confidence: 99%

“…The SLM quercetin yielded particles with a size of less than 5µm, which met the requirements for pulmonary inhalation. Furthermore, aerodynamic mass median (MMAD) testing has been conducted to ascertain the proportion of powder deposited on the alveolar surface, validating the ability of SLM quercetin to penetrate the alveoli (Hariyadi et al, 2022) . An in vitro investigation was carried out to measure the cumulative drug release percentage over a prolonged duration.…”

Section: Plgamentioning

confidence: 99%

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Quercetin in Drug Carriers: Polymer Composite, Physical Characteristics, and In vitro Study

Kurniawan,

Setyawan,

Hariyadi

2024

Sci. Technol. Indones

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Quercetin is a highly prevalent flavonoid commonly found in a wide variety of fruits and vegetables. This compound has various biological actions, indicating great potential in preventing diseases and promoting health but the disadvantages include low solubility and instability. The disadvantages can be overcome by using a polymer composite in the form of microspheres in the formulation. Therefore, this study aimed to review various uses of polymers in delivering quercetin compounds. The results showed that various polymers in microspheres have been formulated with quercetin to minimize the weaknesses. The delivery systems developed and reported from several related studies include microencapsulation, microcapsules, microparticles, microspheres, solid lipid microparticles (SLM), and nanoparticles. Polymers including Gelatine, Maltodextrin and Inulin, Carnauba wax, Poly (lactic-co-glycolic acid (PLGA), Gyceryl behenate, Pectin, Nano-hydroxyapatite, Polycaprolactone, Starch, Chitosan, Eudragit S 100, Sodium Alginate, Ethyl cellulose, and Alumina efficiently improved the properties of quercetin, enabling the utilization as a controlled drug delivery agent. Therefore, developing a quercetin delivery system using composite polymers presents both an opportunity and a challenge for future applications.

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“…Moreover, the morphology, size and size distribution of resulting SLMs were not substantially changed after lyophilization and sterilization (Vanna Sanna et al, 2004). Moreover, Hariya (2022) studied, SLMs made of 5% glyceryl behenate with 2% poloxamer 188 was successfully developed as carriers for Quercetin which had a spherical morphology, good drug loading, and entrapment efficiency (Hariyadi et al, 2022).…”

Section: Figure 2 Hot Homogenization Technique Of Slms Preparationmentioning

confidence: 99%

Effects of lipids and surfactants on the characteristics of asiatic acid-loaded solid lipid microparticles

Witarat

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The objective of this study was to evaluate the effects of solid lipids: beeswax and cetyl alcohol, and surfactants: Tween 80?, soybean lecithin and poloxamer 188 on the characteristics of solid lipid microparticles containing asiatic acid (AASLM). The AASLM were prepared from 10% or 15% of beeswax or cetyl alcohol together with 3% of surfactant F1-F12) by melt dispersion cum freeze-drying technique to obtain a solid dosage form. The physicochemical characteristics of the AASLM powders, including appearance, surface morphology, particle size, %labeled amount of asiatic acid (AA) and %entrapment efficiency (EE) were evaluated. The results revealed that AASLM prepared from 10% or 15% beeswax with 3% soybean lecithin (F2 and F8) could not yield a dry powder form, whereas those with Tween 80? (Tw80) or poloxamer 188 (F1, F3, F7 and F9) appeared as white to slightly yellowish coarse powders. AASLM were prepared from 10% or 15% cetyl alcohol with Tw80 or soybean lecithin or poloxamer 188 and appeared as white fine powders (F4, F5, F6, F10, F11, F12). The mean particle sizes of obtaining AASLM powders ranged from 7.46?0.08 to 38.86?0.34 microns. The surface morphology of AASLM powders, was examined by scanning electron microscope, showed a non-spherical shape. The morphology of AASLM dispersions before freeze-drying and after redispersion of the freeze-dried powder were also investigated using the optical microscope. In all the dispersions, the AASLM prepared from beeswax or cetyl alcohol with poloxamer 188 (F3, F6, F9, F12) had spherical shape, whereas those prepared from beeswax with Tw80 or soybean lecithin (F1, F7, F5, F11) and cetyl alcohol with Tw80 (F4, F10) seemed to have irregular shape. The %labeled amount of AASLMs ranged from 90.43?0.02% to 95.38?0.02% which were considered acceptable. The %EE of resultant AASLMs ranged from 53.75?0.01% to 100.00?0.00%. It was found that F3, F6, F9, F12 could entrap Asiatic acid of 100%. Therefore, it could be concluded that AASLM prepared with beeswax or cetyl alcohol with poloxamer 188 has the greatest potential among the test formulations as a topical carrier for AA. Further studies should be conducted to explore its utilization in cosmetics.

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Characterization of Dry Powder Inhaler Quercetin Solid Lipid Microparticle (Slm) as Lung Deliverysystem: Effect of Polymer Concentration

Cited by 3 publications

References 0 publications

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Quercetin in Drug Carriers: Polymer Composite, Physical Characteristics, and In vitro Study

Effects of lipids and surfactants on the characteristics of asiatic acid-loaded solid lipid microparticles

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