Characterization of electrolytically prepared brushite and hydroxyapatite coatings on orthopedic alloys

Redepenning, Jody; Schlessinger, Tom; Burnham, Sandra; Lippiello, Louis; Miyano, John

doi:10.1002/(sici)1097-4636(199603)30:3<287::aid-jbm3>3.0.co;2-m

Cited by 132 publications

(40 citation statements)

References 26 publications

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“…[21] investigated the effect of the incorporation of hydroxyapatite into a titanium fiber mesh and found an increased push-out strength at 3 and 5 weeks, whereas after 8 weeks, no differences between specimens with and without hydroxyapatite were found. Porous titanium plugs implanted in a rabbit femur showed a significant increase in bone ingrowth for HA coated implants compared to uncoated implants after 6 weeks [19]. Furthermore, the study of Tsukeoka et al [21] supports our findings with regard to the speed of bone ingrowth, that suggests that calcium phosphate coatings work as an accelerator of bone ingrowth.…”

Section: Discussionsupporting

confidence: 84%

“…In the biomimetic coating process, a bioactive coating was produced using an electrodeposition system. A calciumphosphate layer was formed on the metallic specimen after immersion in an artificially prepared supersaturated calcium/phosphate electrochemical solution (Eurocoating, Trento, Italy) [19]. The brushite coating obtained with this method, has a high solubility.…”

Section: Methodsmentioning

confidence: 99%

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Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures

Biemond

Eufrásio

Hannink

et al. 2011

J Mater Sci: Mater Med

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The bone ingrowth potential of biomimetic hydroxyapatite and brushite coatings applied on porous E-beam structure was examined in goats and compared to a similar uncoated porous structure and a conventional titanium plasma spray coating. Specimens were implanted in the iliac crest of goats for a period of 3 (4 goats) or 15 weeks (8 goats). Mechanical implant fixation generated by bone ingrowth was analyzed by a push out test. Histomorphometry was performed to assess the bone ingrowth depth and bone implant contact. The uncoated and hydroxyapatite-coated cubic structure had significantly higher mechanical strength at the interface compared to the Ti plasma spray coating at 15 weeks of implantation. Bone ingrowth depth was significantly larger for the hydroxyapatite- and brushite-coated structures compared to the uncoated structure. In conclusion, the porous E-beam surface structure showed higher bone ingrowth potential compared to a conventional implant surface after 15 weeks of implantation. Addition of a calcium phosphate coating to the E-beam structure enhanced bone ingrowth significantly. Furthermore, the calcium phosphate coating appears to work as an accelerator for bone ingrowth.

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Section: Discussionsupporting

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures

Biemond

Eufrásio

Hannink

et al. 2011

J Mater Sci: Mater Med

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“…22,24 It has a fine crystalline structure, where CaP crystals are fixed on the titanium plasma-sprayed surface in the shape of platelets and pins of 15 μm to 20 μm in length ( Fig. 1) 30 and a high porosity of 60%. This creates an exceptional capillary effect, which enables complete moistening by bone marrow with early adhesion and proliferation of osteoblast-like cells.…”

Section: Methodsmentioning

confidence: 99%

Bone reaction to a biomimetic third-generation hydroxyapatite coating and new surface treatment for the Symax hip stem

Broeke

Alves

Baumann

et al. 2011

The Journal of Bone and Joint Surgery. British volume

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Four uncemented Symax hip stems were extracted at three weeks and nine, 13 and 32 months, respectively, for reasons other than loosening. The reasons for implant removal were infection in two cases, recurrent dislocation in one and acetabular fracture in one. They were analysed to assess the effect and behaviour of an electrochemically deposited, completely resorbable biomimetic BONIT-hydroxyapatite (HA) coating (proximal part) and a DOTIZE surface treatment (distal part) using qualitative histology, quantitative histomorphometry and scanning electron microscopy (SEM). Early and direct bone-implant bonding with signs of active remodelling of bone and the HA coating were demonstrated by histology and SEM. No loose BONIT-HA particles or delamination of the coating were observed, and there was no inflammation or fibrous interposition at the interface. Histomorphometry showed bone-implant contact varying between 26.5% at three weeks and 83.5% at 13 months at the HA-coated implant surface. The bone density in the area of investigation was between 24.6% at three weeks and 41.1% at 32 months. The DOTIZE surface treatment of the distal part of the stem completely prevented tissue and bone apposition in all cases, thereby optimising proximal stress transfer. The overall features of this implant, in terms of geometry and surface texture, suggest a mechanically stable design with a highly active biomimetic coating, resulting in rapid and extensive osseo-integration, exclusively in the metaphyseal part of the stem. Early remodelling of the HA coating does not seem to have a detrimental effect on short-term bone-implant coupling. There were no adverse effects identified from either the BONIT-HA coating or the DOTIZE surface treatment.

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“…Brushite is more soluble than TCP potentially allowing for increased apatite formation when exposed to physiological fluids [93,102,103,104]. Furthermore brushite can be deposited more homogenously on irregularly shaped prosthesis [105]. Human osteoblasts grown on brushite coatings show enhanced differentiation and ECM production compared to non-coated titanium surfaces [106].…”

Section: Implant Surface Enhancements For Enhanced Osteointegrationmentioning

confidence: 99%

“…Human osteoblasts grown on brushite coatings show enhanced differentiation and ECM production compared to non-coated titanium surfaces [106]. Titanium implants with brushite coatings enhanced bone ingrowth when implanted into rabbit femurs [105]. However more in vivo studies are needed to compare the performance of brushite coating with other forms of calcium phosphate coatings.…”

Section: Implant Surface Enhancements For Enhanced Osteointegrationmentioning

confidence: 99%

Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings

Zhang

Myers

Wallace

et al. 2014

IJMS

337

165

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Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic loosening and infection are the two most significant causes of prosthetic implant failure. The ideal implant should be able to promote osteointegration, deter bacterial adhesion and minimize prosthetic infection. Recent developments in material science and cell biology have seen the development of new orthopaedic implant coatings to address these issues. Coatings consisting of bioceramics, extracellular matrix proteins, biological peptides or growth factors impart bioactivity and biocompatibility to the metallic surface of conventional orthopaedic prosthesis that promote bone ingrowth and differentiation of stem cells into osteoblasts leading to enhanced osteointegration of the implant. Furthermore, coatings such as silver, nitric oxide, antibiotics, antiseptics and antimicrobial peptides with anti-microbial properties have also been developed, which show promise in reducing bacterial adhesion and prosthetic infections. This review summarizes some of the recent developments in coatings for orthopaedic implants.

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Characterization of electrolytically prepared brushite and hydroxyapatite coatings on orthopedic alloys

Cited by 132 publications

References 26 publications

Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures

Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures

Bone reaction to a biomimetic third-generation hydroxyapatite coating and new surface treatment for the Symax hip stem

Bioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings

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