Characterization of fenvalerate residues in dairy cattle and poultry

Boyer, Alvin C.; Lee, Philip W.; Potter, John C.

doi:10.1021/jf00017a044

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…Small amounts of pyrethroid can, however, persist in fatty tissues of food-producing animals for extended periods of time. For example, Boyer et al 17 reported that fatty tissues collected from cattle 20 days after exposure retained small amounts of unchanged fenvalerate. Similarly, Quistad et al 18 estimated that, eight days after oral treatment of cattle with Ñuvalinate, approximately 1É6% of the total dose remained in fat.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Intravenous Fenvalerate in Cattle Treated Topically with a Low Dose of Piperonyl Butoxide

1997

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: Experiments were conducted to identify pharmacokinetic interactions between topically applied piperonyl butoxide and intravenous fenvalerate in cattle (Angus steers). Intact fenvalerate in plasma was derivatized by condensation with acetone and measured by negative chemical ionization gas chromatography/mass spectrometry. Noncompartmental pharmacokinetic analyses indicated that the elimination-phase rate constant (b, 0É000 69 (^0É000 06) min~1), mean residence time (172 (^14) min), systemic clearance (10É4 (^0É7) ml min~1 kg~1) or volume at steady state (1800 (^230) ml kg~1) were not changed (P [ 0É05) after topical application of a low dose of piperonyl butoxide. These data indicate that topical application of a low dose of the metabolic synergist piperonyl butoxide would not be expected to modify the in-vivo disposition of fenvalerate in cattle.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Intravenous Fenvalerate in Cattle Treated Topically with a Low Dose of Piperonyl Butoxide

1997

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“…Fenvalerate I is rapidly degraded (t 1/2 Х 15 days) in most environments (Hill, 1981), yielding fenvaleric acid II [2-(4chlorophenyl)-3-methyl-butanoic acid] (Agnihotri et al, 1986;Okhawa et al, 1978) as a major metabolite. The presence of fenvalerate residues have been detected in crops (Greenberg, 1981;Patel et al, 1990) and food products such as milk, eggs, and beef (Boyer et al, 1992). However, human exposure through food and beverage is considered low (UN-WHO, 1990).…”

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confidence: 99%

Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats

Morisseau

Derbel

Lane

et al. 1999

Toxicological Sciences

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Racemic fenvaleric acid [2-(4-chlorophenyl)-3-methyl-butanoic acid], the principal metabolite of fenvalerate, was administrated orally at 0.75, 1.5, and 3.0 mmol/kg body weight/day to Fisher-344 male rats for 7 days. Both pure enantiomers of fenvaleric acid were administered at 1.5 mmol/kg body weight/day; the clofibric acid at the same concentration was used as a positive control. Hepatic enzyme activities were measured. Results obtained clearly show that fenvaleric acid induced numerous hepatic drug metabolism enzymes in F344 rats. The (R) enantiomer of this compound induces a proliferation of peroxisomes, whereas the (S) enantiomer induces CYP2B and mEH activities. Therefore, high exposure to pyrethroid insecticides could interact with the normal metabolism of drugs or xenobiotics.

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“…A população humana está exposta a este inseticida ocupacionalmente e também através do consumo de alimentos que contenham resíduos do piretróide. Quantidades significativas de resíduos de fenvalerato têm sido detectadas em frutas e vegetais (Patel et al, 1990;Boyer et al, 1992). Em um estudo realizado nos E.U.A., maças foram tratadas com um concentrado emulsificado a 30% de fenvalerato, por 4 vezes, em uma taxa de 0,67kg de ingrediente ativo/ha.…”

Section: Inseticidas Piretróidesunclassified

Parametros reprodutivos masculinos e fertilidade de ratos adultos expostos ao inseticida fenvalerato

Arena¹,

Kempinas²

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Fenvalerate is a synthetic pyrethroid insecticide widely used in agriculture to control a variety of insects. Although it is considered to be of low acute toxicity to mammals, studies have showed that pyrethroids can have estrogenic activity and can act as endocrine disruptors, causing important reproductive impairment in males. It is documented in the literature that the exposure of pregnant rats to fenvalerate decreased plasma testosterone levels and weights of seminal vesicle and vas deferens in male pups during adult life, besides alterations in their sexual behavior. It was also observed that adult rats exposed to formulated fenvalerate, by inhalation, exhibited a significant reduction in the testis weight and epididymal sperm count. Little is known about the mechanisms by which fenvalerate exerts its action on reproduction; thus, the objective of the present study was to investigate the estrogenic activity and the effects of fenvalerate on the reproductive system and fertility of adult male rats. For this, adult male rats (aged 90 days) received, for 30 consecutive days, by oral gavage, 40 mg/kg/day of fenvalerate (technical grade;Reproductive toxicity of the pyrethroid insecticide fenvalerate on adult male rats

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Characterization of fenvalerate residues in dairy cattle and poultry

Cited by 7 publications

References 10 publications

Pharmacokinetics of Intravenous Fenvalerate in Cattle Treated Topically with a Low Dose of Piperonyl Butoxide

Pharmacokinetics of Intravenous Fenvalerate in Cattle Treated Topically with a Low Dose of Piperonyl Butoxide

Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats

Parametros reprodutivos masculinos e fertilidade de ratos adultos expostos ao inseticida fenvalerato

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