Characterization of fluorinated metabolites by a gas chromatographic-helium microwave plasma detector—The biotransformation of 1H,1H,2H,2H-perfluorodecanol to perfluorooctanoate

Hagen, D.F.; Belisle, Jon; Johnson, J. Donald; Venkateswarlu, P.

doi:10.1016/0003-2697(81)90591-1

Cited by 131 publications

(127 citation statements)

References 12 publications

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“…The reduction of PFOS in effluents has also been observed in WWTPs by Schultz et al [17]. The existence of potential sources of PFCs in the form of precursor compounds or other telomers within the wastewater treatment, such as POSF (perfluorooctane sulfonyfluoride)-based perfluorochemicals and fluorotelomer alcohols (FTOHs), has been reported in several earlier studies [20,30,31]. These compounds have been widely used as surfactants and in the process of a variety of products from the 1950s and some of them are still in use today.…”

Section: Potential Sources Of Pfcs In Wastewatersmentioning

confidence: 71%

Evaluation of perfluorinated compounds in seven wastewater treatment plants in Beijing urban areas

et al. 2010

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The presence of perfluorinated compounds (PFCs) in seven major wastewater treatment plants (WWTPs) in Beijing was investigated in the current study. We detected nine PFCs in all the wastewater and sludge samples. Perfluorooctane acid (PFOA) is the dominant PFCs in influents and effluents, while perfluorooctane sulfonate (PFOS) is the major contaminant in sludge. The highest PFC concentration was found in plants at Qinghe and Jiuxianqiao WWTP, while the lowest was found at Fangzhuang WWTP. The total values of PFC range from 2.88 to 176 ng/L in influents, from 5.48 to 498 ng/L in effluents, and from 1.21 to 32.0 ng/g (dry wt) in sludge. The fact that effluents usually contain higher levels of PFCs than influents suggests that additional PFCs are produced during the wastewater treatment processes. However, PFOS decreases in effluents than in influents in 62% of the water samples. This may be due to the adsorption and removal of the sludge during the active process. Perfluoroalkyl carboxylates (PFCAs) were found significantly correlated with each other in the effluents, which may indicate their similar sources or the existence of their potential precursors in the wastewater or treatment processes. The mass flows of PFC discharges into WWTPs are 0.4-51.4 mg/day, and the mass flows of PFCs in effluents exceed those in influents by 127%. Domestic and commercial wastewaters are suggested to be the major sources of PFC pollution in WWTPs in Beijing. perfluorinated compounds, wastewater, sludge, mass flow

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Section: Potential Sources Of Pfcs In Wastewatersmentioning

confidence: 71%

Evaluation of perfluorinated compounds in seven wastewater treatment plants in Beijing urban areas

et al. 2010

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“…Evidence for biotransformation of the FTOHs to the FTCAs and FTUCAs exists for both microbes (2,3,21) and mammals, both in vivo (40) and in vitro (38), and it likely occurs in all exposed organisms, including humans. Our data, therefore, suggest that further consideration of the toxicology of telomer acids is warranted.…”

Section: Resultsmentioning

confidence: 99%

Fluorotelomer Acids are More Toxic than Perfluorinated Acids

Phillips

Dinglasan-Panlilio

Mabury

et al. 2007

Environ. Sci. Technol.

120

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Saturated and unsaturated fluorotelomer carboxylic acids have been identified as intermediates in the degradation of fluorotelomer alcohols to perfluorinated carboxylic acids (PFCAs). Although surface waters are the likely environmental sink for telomer acids, no fate or toxicity data exist for this matrix. We assessed the acute toxicity of the 4:2, 6:2, 8:2, and 10:2 saturated (FTCA) and unsaturated (FTUCA) fluorotelomer carboxylic acids to Daphnia magna, Chironomus tentans, and Lemna gibba. In general, toxicity increased with increasing fluorocarbon (FC) chain length, particularly for telomer acids of g8 FCs. In addition, the FTCAs were generally more toxic than the corresponding FTUCAs. Acute EC50s ranged from 0.025 mg/L (0.04 µmol/L) for D. magna (10:2 FTCA, immobility) to 63 mg/L (167 µmol/L) for C. tentans (6:2 FTCA, growth). While chain-length trends observed in the current study agree with those previously reported for PFCAs, the toxicity thresholds generated here are up to 10 000 times smaller. Our data provide the first evidence that PFCA precursors are more toxic than the PFCAs themselves.

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“…In a biodegradation study of N-EtFOSE, PFOA could be formed instead of PFOS only under an abiotic or hydrolytic condition during the last step of the degradation pathway (Lange 2001). PFOA could also be an oxidation product or metabolite of the widely used telomer-based fluorochemicals manufactured by other companies (Hagen et al 1981). PFHS, the sulfonate form of perfluorohexanesulfonyl fluoride (PHSF), could also be a residual by-product of POSFbased production.…”

Section: Fluorochemicalsmentioning

confidence: 99%

Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.

Olsen

Church

Miller

et al. 2003

Environ Health Perspect

369

309

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Perfluorooctanesulfonyl fluoride-based products have included surfactants, paper and packaging treatments, and surface protectants (e.g., for carpet, upholstery, textile). Depending on the specific functional derivatization or degree of polymerization, such products may degrade or metabolize, to an undetermined degree, to perfluorooctanesulfonate (PFOS), a stable and persistent end product that has the potential to bioaccumulate. In this investigation, a total of 645 adult donor serum samples from six American Red Cross blood collection centers were analyzed for PFOS and six other fluorochemicals using HPLC-electrospray tandem mass spectrometry. PFOS concentrations ranged from the lower limit of quantitation

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Characterization of fluorinated metabolites by a gas chromatographic-helium microwave plasma detector—The biotransformation of 1H,1H,2H,2H-perfluorodecanol to perfluorooctanoate

Cited by 131 publications

References 12 publications

Evaluation of perfluorinated compounds in seven wastewater treatment plants in Beijing urban areas

Evaluation of perfluorinated compounds in seven wastewater treatment plants in Beijing urban areas

Fluorotelomer Acids are More Toxic than Perfluorinated Acids

Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.

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