Climate change, vegetation dynamics, human activities and forest management influence the occurrence of fires. This study investigated the spatio-temporal variability of the Vegetation Condition Index (VCI) and its influence on fire occurrence in three different land use types in Mount Kenya Forest Reserve and National Park (MKFRNP): National Park (NP), Forest Stations (FS) and Farmlands (FL). The study used MODIS satellite data to obtain the Normalized Difference Vegetation Index (NDVI), the VCI, the number of fires and the burnt area. The specific objectives of this research were (i) to examine the spatio-temporal variability of VCI, fire occurrence and burnt area in MKFRNP from 2003 to 2018 and (ii) to explore the relationship between VCI, fire occurrence and burnt area in different areas of the MKFRNP (NP, FS and FL). The findings show that even though fires occur throughout the year in MKFRNP, most of the fires occur during dry seasons. The relationship between spatio-temporal fire occurrence and VCI distribution is different for each land use type. In the FL, the probability of fire ignition and the number of fires per month was more or less the same irrespective of the VCI because of the traditional use of fire as a land management tool. However, the probability of fire ignition and the number of fires per month is high in the NP and FS when the VCI is below 50% (drought), especially in the dry seasons, when and where the impact of meteorological conditions and climate have much more impact than human activities. In addition to the efforts already made by communities, KFS and KWS in the fire fighting and monitoring system, satellite data can be useful to acquire accurate and timely information on the VCI and the likely spatio-temporal occurrence of fires in order to be prepared in the most fire-prone periods and improve fire management, the planning of resources and fire suppression activities in MKFRNP.