Characterization of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties

Alam, Muhammad Irfan; Paget, Timothy A.; Elkordy, Amal

doi:10.1016/j.powtec.2016.03.026

Cited by 9 publications

(2 citation statements)

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“…Chitosan is a linear polysaccharide composed of chains β(1 → 4) Dglucosamine and N-acetyl-D-glucosamine [15,16]. It is produced by deacetylation of chitin, which is a structural element in the exoskeleton of crustaceans and one of the most widely available natural polymers in nature [17,18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of chitosan membranes functionalized with amino acids and copper for adsorption of endoglucanase

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of chitosan membranes functionalized with amino acids and copper for adsorption of endoglucanase

et al. 2017

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“…At acidic pH, it carries a positive charge that allows the formation of electrostatic complexes or multiple networks with other anionic polymers (natural or synthetic) [ 21 ]. Moreover, the presence of hydroxyl (OH) and amine (NH 2 ) groups on chitosan contribute to hydrogen bonding [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Tofacitinib Loaded pH-Responsive Chitosan/Mucin Based Hydrogel Microparticles: In-Vitro Characterization and Toxicological Screening

Malatani

Bilal

Mahmood

et al. 2023

Gels

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Tofacitinib is an antirheumatic drug characterized by a short half-life and poor permeability, which necessitates the development of sustained release formulation with enhanced permeability potential. To achieve this goal, the free radical polymerization technique was employed to develop mucin/chitosan copolymer methacrylic acid (MU-CHI-Co-Poly (MAA))-based hydrogel microparticles. The developed hydrogel microparticles were characterized for EDX, FTIR, DSC, TGA, X-ray diffraction, SEM, drug loading; equilibrium swelling (%), in vitro drug release, sol–gel (%) studies, size and zeta potential, permeation, anti-arthritic activities, and acute oral toxicity studies. FTIR studies revealed the incorporation of the ingredients into the polymeric network, while EDX studies depicted the successful loading of tofacitinib into the network. The thermal analysis confirmed the heat stability of the system. SEM analysis displayed the porous structure of the hydrogels. Gel fraction showed an increasing tendency (74–98%) upon increasing the concentrations of the formulation ingredients. Formulations coated with Eudragit (2% w/w) and sodium lauryl sulfate (1% w/v) showed increased permeability. The formulations equilibrium swelling (%) increased (78–93%) at pH 7.4. Maximum drug loading and release (%) of (55.62–80.52%) and (78.02–90.56%), respectively, were noticed at pH 7.4, where the developed microparticles followed zero-order kinetics with case II transport. Anti-inflammatory studies revealed a significant dose-dependent decrease in paw edema in the rats. Oral toxicity studies confirmed the biocompatibility and non-toxicity of the formulated network. Thus, the developed pH-responsive hydrogel microparticles seem to have the potential to enhance permeability and control the delivery of tofacitinib for the management of rheumatoid arthritis.

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Recent progress in the structural modification of chitosan for applications in diversified biomedical fields

Mittal

Ray

Kaith

et al. 2018

European Polymer Journal

167

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Characterization of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties

Abstract: Characterisation of furazolidonechitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties. Powder Technology, 295. pp. 175179.

Cited by 9 publications

References 16 publications

Synthesis and characterization of chitosan membranes functionalized with amino acids and copper for adsorption of endoglucanase

Synthesis and characterization of chitosan membranes functionalized with amino acids and copper for adsorption of endoglucanase

Development of Tofacitinib Loaded pH-Responsive Chitosan/Mucin Based Hydrogel Microparticles: In-Vitro Characterization and Toxicological Screening

Recent progress in the structural modification of chitosan for applications in diversified biomedical fields

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