Characterization of gamma-ray and neutron radiation absorption properties of synthesized quinoline derivatives and their genotoxic potential

Alaylar, Burak; Aygün, Bünyamin; Turhan, Kadir; Karadayı, Gökçe; Şakar, Erdem; Singh, V.P.; Sayyed, M.I.; Pelit, Emel; Karabulut, Abdülhalik; Güllüce, Medine; Turgut, Zühal; İsaoğlu, Mine

doi:10.1016/j.radphyschem.2021.109471

Cited by 42 publications

(8 citation statements)

References 26 publications

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“…These numerous applications demonstrate the necessity of radiation in our daily lives. Despite these benefits, it is important to keep in mind the potentially dangerous nature of radiation [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Potentials of Egyptian and Indian Granites for Protection of Ionizing Radiation

et al. 2021

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This paper aims to study the radiation shielding characteristics and buildup factor of some types of granite in Egypt. The mass attenuation coefficient (MAC) for three types of granite (gandola, white halayeb, and red aswani) was experimentally determined, and the experimental results were validated by XCOM software. The relative deviation between the two methods does not exceed 3% in all discussed granite samples, which means that MAC calculated through the experimental and XCOM are in suitable agreement. The effective atomic number (Zeff) varies from 13.64 to 10.69, 13.68 to 10.59, and 13.45 and 10.66 for gandola, white halayeb, and red aswani, respectively. As well as the equivalent atomic number (Zeq) was calculated in a wide range of energy to deduce the exposure (EBF) and energy absorption (EABF) buildup factors for the studied granite materials. The linear attenuation coefficient (LAC), half-value layer (HVL), mean free path (MFP) were calculated at each investigated energy and showed that the most effective shielding ability at high energy was red aswani, while at low energy, the shielding ability was nearly constant for studied granites. The present study forms the first endeavor to obtain the radiation shielding properties of the studied materials to be used in practical applications.

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Section: Introductionmentioning

confidence: 99%

The Potentials of Egyptian and Indian Granites for Protection of Ionizing Radiation

et al. 2021

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“…The same information is important for other applications as well. Due to the absence of electric charge in gamma rays, the study of the mechanisms of attenuation of gamma radiation in matter is an urgent task [9][10][11] and one of the most important aspects of the use of gamma rays in nuclear medicine [12,13].…”

Section: Introductionmentioning

confidence: 99%

Application of the medical linear accelerator ELEKTA AXESSE in the study of sorption properties of impurities and absorption coefficients of medium and heavy chemical elements

Zaripova

Gladkikh

Bigeldiyeva

et al. 2022

J. Phys.: Conf. Ser.

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In this article, the authors propose a new technique for measuring linear attenuation coefficients on the medical linear accelerator Elekta Axesse. Linear attenuation coefficients were obtained for four samples at different concentrations of substances at a gamma-ray energy of 6 MeV. A unified ionization chamber was used as a detector to register the transmitted gamma-ray beam through the samples under study. Linear absorption coefficients were obtained for elements B, C, O, S, Fe, Ba taking into account their concentration, as well as taking into account the different mass inclusion of paraffin in the samples under study, which is acyclic hydrocarbons CnH2n+2. The measurement results showed that taking into account certain components in impurities leads to relatively small, but quite noticeable differences in the determination of the total absorption coefficients. This is especially important to take into account for determining the concentration of light elements in samples. To determine the content of medium and heavy chemical elements, taking into account the content of light elements can be neglected. The use of a 6 MeV gamma-ray beam made it possible to reduce the errors in determining the absorption coefficients, since their dependence on energy in the region of applicable gamma-ray energies is not so great in comparison with the low-energy region, in which the shell effects for heavy elements will introduce significant contribution.

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“…When compared to commercial medications, studies have revealed that substituted 2‐Cyanoquinoline derivatives have higher in vitro and in vivo 5‐LOX inhibitory property [12–14] . 2‐Substituted 4‐phenylquinolines have the potential to be used as an antidepressant [15] . 2‐Aminoquinoline‐based scaffolds were found to be Neuronal Nitric Oxide Synthase Inhibitors [16–19] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Quinoline and Polyhydroquinoline Derivatives Using Phloroglucinol Cored Amino Functionalized Dendritic Polymer as Catalyst

et al. 2022

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Phloroglucinol cored primary amine-functionalized G0 dendritic polymer (PHGÀ G0) was effectively synthesized. The polymer was characterized by different spectroscopic and analytical techniques including Fourier transform infrared (FT-IR) and Nuclear magnetic resonance (NMR) spectra, Thermogravimetric Analysis (TG-DTG) and Gel Permeation Chromatography (GPC). The catalytic efficiency of the PHGÀ G0 was evaluated in the three-component one-pot green synthesis of quinoline and four component synthesis of polyhydroquinoline derivatives. Quinoline derivatives were obtained 92 % of yield within 60 minutes in water/ethanol (1 : 1) (v/v) mixture as solvent and polyhydroquinoline derivatives were obtained 90 % of yield within 30 minutes in acetonitrile as solvent under reflux conditions. High amino group capacity and high thermal stability made the PHGÀ G0 dendritic polymer a good base catalyst. All the quinoline and polyhydroquinoline derivatives were characterized by determining the melting point, Fourier transform infrared (FT-IR) and Nuclear magnetic resonance (NMR) spectra. The present method is green, efficient, and costeffective. Catalyst can be reused up to four reaction cycles without any characteristic loss of its activity.

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Characterization of gamma-ray and neutron radiation absorption properties of synthesized quinoline derivatives and their genotoxic potential

Cited by 42 publications

References 26 publications

The Potentials of Egyptian and Indian Granites for Protection of Ionizing Radiation

The Potentials of Egyptian and Indian Granites for Protection of Ionizing Radiation

Application of the medical linear accelerator ELEKTA AXESSE in the study of sorption properties of impurities and absorption coefficients of medium and heavy chemical elements

Synthesis of Quinoline and Polyhydroquinoline Derivatives Using Phloroglucinol Cored Amino Functionalized Dendritic Polymer as Catalyst

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