Characterization of genetic differences in hormone-induced ovulation rate in mice

Spearow, Jimmy L.

doi:10.1530/jrf.0.0820799

Cited by 23 publications

(19 citation statements)

References 14 publications

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“…These results contrast with the findings of Eleftheriou et al (1972), Eleftheriou & Kristal (1974), and Spearow (1980) of large strain differences in ovulation rate induced by a single injection of gonadotrophin. Other studies suggest that the genetic differences in hormone-induced ovulation rate observed in the present study were due to genetic differences in the ovarian responsiveness to large doses of exogenous gonadotrophins (Spearow, 1988).…”

Section: Discussionsupporting

confidence: 52%

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Major genes control hormone-induced ovulation rate in mice

Spearow

1988

Reproduction

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Summary. The present study examined the magnitude of genetic variation, mode of inheritance and number of loci controlling major genetic differences in hormone\x=req-\ induced ovulation rate in mice. Mice were injected with 5 i.u. PMSG at 28 days of age and 5 i.u. hCG at 30 days, and hormone-induced ovulation rate was determined from counts of oviducal eggs in cumulus the next morning. Six-fold genetic differences in induced ovulation rate were detected amongst strains, ranging from a low mean ( \ m=+-\ s.e.) value of 8\m=.\8 (\m=+-\0\m=.\9) in A/J up to 53\m=.\5 (\m=+-\2\m=.\2) in C57BL/6J. The number of ova differed significantly amongst strains and amongst F1 crosses (P < 0\m=.\0001): 70% of the variation in hormone-induced ovulation rate was amongst strains. Of 9 F1 crosses examined, 4 showed positive heterosis, 3 showed no heterosis and 2 showed negative heterosis for hormone-induced ovulation rate. Analysis of parental, F1 and F2 generations revealed that the induced ovulation rate of A/J and C57BL/6J mice differed due to the action of about 3 or 4 loci, and A.SW/SnJ and SJL/J mice differed due to the action of about 2 to 3 loci. Analysis of recombinant inbred strains formed from A/J and C57BL/6J confirmed that these strains differed due to the action of a small number of loci. This study demonstrates the existence of a small number of major genes controlling hormone-induced ovulation rate in young mice.

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Section: Discussionsupporting

confidence: 52%

“…1 of the present study, or the number of fresh eggs ovulated by 5 i.u. hCG alone (Spearow, 1988), suggests that strain differences in the maturation of follicles by endogenous gonadotrophins, which can be ovulated by 5 i.u. PMSG or 5 i.u.…”

Section: Discussionmentioning

confidence: 99%

Major genes control hormone-induced ovulation rate in mice

Spearow

1988

Reproduction

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“…Nonetheless, this issue has been poorly investigated and more studies are needed (James et al 2006). Little is known also about possible strain differences in the onset and expression of puberty in male mice (Osadchuk et al 2008), although studies carried out in female mice demonstrated different strain-specific profiles of sexual maturation (Spearow 1988). Nonetheless, as the onset of puberty for either strain certainly falls within the agewindow studied here, it is unlikely that strain differences in the onset of puberty account for the lack of age-differences in startle-like behaviors in the D2 strain.…”

Section: Discussionmentioning

confidence: 99%

Strain-Dependent Changes in Acoustic Startle Response and its Plasticity Across Adolescence in Mice

Pietropaolo

Crusio

2009

Behav Genet

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Acoustic startle response and its plasticity, e.g., habituation and prepulse inhibition (PPI), have been extensively investigated, being altered in several neuropsychiatric disorders. Yet, little is known about the expression of startle-related behaviors during adolescence, a critical phase in the development of a variety of major neuropsychiatric pathologies. The present study investigated for the first time startle behaviors across adolescence in male mice of the inbred strains C57BL/6J and DBA/2J. Pre-pubertal (4 weeks of age) mice displayed reduced startle reactivity and altered PPI compared to adult animals (8 weeks of age), but these effects were observed only in the C57BL/6J strain. Strain differences were also clearly detected for startle response, habituation, and PPI. All effects were modulated by the intensity of the pulse stimulus and were not confounded by differences in anxiety levels. Our data demonstrate that genetic factors and the early adolescent phase are critically important considerations in the design of mouse models of neuropsychiatric disturbances.

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“…Genetic strain variations in mice with regard to in vitro fertilization (Kaleta 1977), cleavage rates (McLaren & Bowman 1973, Luckett & Mukherkee 1986, pH regulation (Steeves et al 2001), parthenogenetic activation (Gao et al 2004, Ibáñ ez et al 2005) and preimplantation development (Suzuki et al 1996) buttress the well-known relationship between fecundity and genetic background amongst hybrid F1, inbred and outbred lines (Silver 1995). Additionally, variations in hormone sensitivity influence ovulation rate amongst different mouse strains (Spearow 1988, Spearow et al 1999) and the rate of meiotic maturation in vivo or in vitro can vary depending on genetic background (Polanski 1986(Polanski , 1997. Thus, it seems likely that some of the genetic factors that specify embryo quality find their roots in maternal preconceptional processes associated with oogenesis and ovulation.…”

Section: Introductionmentioning

confidence: 99%

Genetic strain variations in the metaphase-II phenotype of mouse oocytes matured in vivo or in vitro

Ibáñez

Sanfins²,

Combelles³

et al. 2005

Reproduction

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The interplay between genetic and epigenetic factors plays a central role in mammalian embryo production strategies that superimpose ex vivo or in vivo manipulations upon strain background characteristics. In this study, we examined the relationship between genetic background and the phenotypic properties of mouse metaphase-II (M-II) oocytes that were matured under in vivo (IVO) or in vitro conditions, either in a basal (IVM) or a supplemented (IVM 1 ) medium. Differences existed amongst inbred (C57BL/6), outbred (CF-1, Black Swiss, NU/NU) and hybrid lines (B6D2F1) induced to superovulate with regard to cytoplasmic microtubule organizing center (MTOC) number but not spindle size or shape, except for larger and asymmetrical spindles in Black Swiss oocytes. When oocytes were matured in culture, meiotic spindle and cytoplasmic phenotypic properties of M-II oocytes were affected relative to in vivo conditions and between strains. Specifically, measures of meiotic spindle size, shape, polar pericentrin distribution and cytoplasmic MTOC number all revealed characteristic variations. Interestingly, the overall reduction in cytoplasmic MTOC number noted upon IVM was concomitant with an overall increase in spindle and polar body size. Maturation under IVM 1 conditions resulted in a further decrease in cytoplasmic MTOC number, but spindle and polar body characteristics were intermediate between IVO and IVM. How these oocyte phenotypic properties of maternal origin may be linked to predictive assessments of fecundity remains to be established.

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Characterization of genetic differences in hormone-induced ovulation rate in mice

Cited by 23 publications

References 14 publications

Major genes control hormone-induced ovulation rate in mice

Major genes control hormone-induced ovulation rate in mice

Strain-Dependent Changes in Acoustic Startle Response and its Plasticity Across Adolescence in Mice

Genetic strain variations in the metaphase-II phenotype of mouse oocytes matured in vivo or in vitro

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