Characterization of genotoxin-encoding Escherichia coli isolated from specific-pathogen free cats with impaired fertility

Mannion, Anthony; McGee, W.K.; Feng, Yan; Shen, Zeli; Buckley-Jordan, Ellen; Dzink-Fox, JoAnn; Fox, James G.

doi:10.1016/j.vetmic.2022.109337

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…that encodes CdtB, produces the toxic molecule CDTs ( Lai et al., 2021 ). Due to immunomodulatory activity, CDTs may promote the persistence of infection, thereby prompting GBC ( Mannion et al., 2022 ). Third, some studies determined the correlation between Vi antigen of S. Typhi in serum samples and GBC ( Nath et al., 2008 ; Shukla et al., 2021 ).…”

Section: Bacteria In Gbc Pathogenesismentioning

confidence: 99%

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Liu,

Li,

Chen

et al. 2024

Front. Cell. Infect. Microbiol.

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Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty achieving a clinical cure. The risk of tumor recurrence remains more than 65%, and the overall 5-year survival rate is less than 5%. The gut microbiota refers to a variety of microorganisms living in the human intestine, including bacteria, viruses and fungi, which profoundly affect the host state of general health, disease and even cancer. Over the past few decades, substantial evidence has supported that gut microbiota plays a critical role in promoting the progression of GBC. In this review, we summarize the functions, molecular mechanisms and recent advances of the intestinal microbiota in GBC. We focus on the driving role of bacteria in pivotal pathways, such as virulence factors, metabolites derived from intestinal bacteria, chronic inflammatory responses and ecological niche remodeling. Additionally, we emphasize the high level of correlation between viruses and fungi, especially EBV and Candida spp., with GBC. In general, this review not only provides a solid theoretical basis for the close relationship between gut microbiota and GBC but also highlights more potential research directions for further research in the future.

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Section: Bacteria In Gbc Pathogenesismentioning

confidence: 99%

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Liu,

Li,

Chen

et al. 2024

Front. Cell. Infect. Microbiol.

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“…The activation of Rho-GTPases by cytotoxic necrotizing factor ( cnf ) causes alterations in the cytoskeleton and affects the cell cycle. The cycle-inhibiting factor ( cif ) hijacks host cell signaling pathways by targeting NEDD8-conjugated cullins ( Mannion et al., 2022 ). The genotoxin colibactin is a hybrid polyketide–non-ribosomal peptide.…”

Section: Introductionmentioning

confidence: 99%

Phenotypicand Genotypic Characterization of Clinical Isolates of Intracellular Adherent–Invasive Escherichia coli Among Different Stages, Family History, and Treated Colorectal Cancer Patients in Iran

Dolatabadi

Fazeli

Karbasizade

et al. 2022

Front. Cell. Infect. Microbiol.

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There is increasing evidence showing that microbial dysbiosis impacts the health and cancer risk of the host. An association between adherent–invasive Escherichia coli (AIEC) and colorectal cancer (CRC) has been revealed. Cyclomodulins (CMs) have been receiving increasing attention for carcinogenic changes. In this study, the incidence and features of intracellular AIEC and cyclomodulin-encoding genes were investigated and the phylogenetic grouping and genetic relatedness were evaluated. E. coli strains were isolated from the colorectal biopsies. Adhesion and invasion assays and intramacrophage cell survival test were performed to separate the AIEC isolates. Virulence genotyping for the genes htrA, dsbA, chuA, and lpfA and the cyclomodulin toxins was also conducted. In addition, phylogenetic grouping of the isolates was determined. Subsequently, repetitive element sequence-based PCR (rep-PCR) fingerprinting was performed. A total of 24 AIEC pathovars were isolated from 150 patients. The prevalence rates of htr, dsbA, and lpfA were 70.83% and that of chuA was 91.66%. The frequencies of the cyclomodulin toxins were as follows: cnf1, 29.2%; cnf2, 25%; colibactin, 29.2%; and cdt, 4.2%; cif was not found. Among the AIEC isolates, 4.2%, 4.2%, 54.2%, 29.2%, and 8.3% with phylotypes A or C, B1, B2, D, and E were identified, respectively. Left-sided colon carcinoma and adenocarcinoma T≥1 stage (CRC2) were colonized by B2 phylogroup AIEC-producing CMs more often than the samples from the other groups. Close genetic relatedness was observed in AIEC isolates with rep-PCR.

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