Characterization of gold nanoparticle films: Rutherford backscattering spectroscopy, scanning electron microscopy with image analysis, and atomic force microscopy

Lansåker, Pia; Hallén, Anders; Niklasson, Gunnar A.; Granqvist, Claes‐Göran

doi:10.1063/1.4897340

Cited by 5 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The characterization of the gold nanoparticle film was reported in other studies. 17,23 However, how the surface roughness affects the cells remains unclear. In nanoparticle-enhanced radiation therapy, cells are decorated by a number of randomly distributed nanoparticles, while, in the current platform, only the bottom side of cells contact with the substrate.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Evaluating Single-Cell DNA Damage Induced by Enhanced Radiation on a Gold Nanofilm Patch

Qiao

Zhou

Xiao

et al. 2017

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Although radiotherapy is a general oncology treatment and is often synergistically applied with surgery and chemotherapy, it can cause side effects during and after treatment. Gold nanoparticles were studied as a potential material to enhance radiation to induce damage in cancer cells. However, few studies have been conducted to examine the effects of gold nanofilm on cell impairment under X-ray treatment. This paper describes a microfabrication-based single-cell array platform to evaluate DNA damage induced by enhanced X-ray radiation on gold nanofilm patches (GNFPs). Cancer cells were patterned on GNFPs of different diameters and thicknesses, where each cell was attached on one GNFP. The end-point DNA damage induced by X-ray was examined in situ at the single-cell level using a halo assay. The preliminary data demonstrated that the enhancement of DNA damage was significantly related to the area and thickness of the GNFP. This platform may be hopefully used to establish the mathematical relationships among DNA damage, X-ray dosage, and thickness and area of the GNFP, and further contribute to radiation dosage screening for personalized radiotherapy.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

Evaluating Single-Cell DNA Damage Induced by Enhanced Radiation on a Gold Nanofilm Patch

Qiao

Zhou

Xiao

et al. 2017

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…In addition to these techniques, ion beam analysis methods such as Rutherford backscattering spectrometry (RBS), time-of-flight secondary ion mass spectrometry (ToF-SIMS), and medium energy ion scattering (MEIS) are powerful characterization tools for the study of nanoparticles. These techniques can provide high-accuracy information on the nanoparticles' elemental composition, size, and shape [16,17].…”

Section: Introductionmentioning

confidence: 99%

Novel deposition method for gold and platinum nanoparticles on silicon substrates utilizing poly (ethylene glycol) 6000 for MEIS analysis

Klippel,

Fonteles,

Torgo

et al. 2024

J. Phys. D: Appl. Phys.

View full text Add to dashboard Cite

The use of nanoparticles has significantly increased in many areas, such as biomedical research, being highly useful as nanoprobes for imaging and as nanocarriers for drug delivery applications. Nevertheless, this potential can only be achieved with the correct characterization of the nanoparticles, since their size and shape can directly affect their biological behavior. \textcolor{red}{In this study, we propose a novel approach for a monolayer deposition of gold and platinum nanoparticles on Si substrates suitable for Medium Energy Ion Scattering (MEIS) analysis. The samples were prepared using PEG 6000 as a coating agent for the substrates, utilizing a spin coater—a versatile, cost-effective, and practical technique. The samples were first analyzed with the RBS technique to assess the adhesion and the overlapping of the nanoparticles in the substrates coated with PEG 6000 and then characterized through the MEIS technique.} The analysis through MEIS allowed the determination of the shape, size, and coverage area of the nanoparticles. Scanning and transmission electron microscopy were also performed on the samples, with the results corroborating the findings of the MEIS experiment. Together, the data obtained with microscopy and the MEIS technique suggests the effectiveness of the method in the production of monolayer samples.

show abstract

“…The AGD process allows for log-normal size distribution of the nanoparticles, and monodisperse, ultrapure nanoparticles can be produced. Therefore, the nanoparticles are less prone to agglomeration and coalescence, which are the major problems in the case of the MNPs prepared by other physical methods [25,26].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterisation of ligand-functionalised ultrapure monodispersed metal nanoparticle nanoassemblies employing advanced gas deposition technique

et al. 2018

View full text Add to dashboard Cite

Here, we report for the first time the fabrication of ligand-functionalised ultrapure monodispersed metal nanoparticles (Au, Cu, and Pt) from their pure metal precursors using the advanced gas deposition technique. The experimental conditions during nanoparticle formation were adjusted in order to obtain ultrafine isolated nanoparticles on different substrates. The morphology and surface analysis of the as-deposited metal nanoparticles were investigated using scanning electron microscopy, x-ray diffraction and Fourier transform infra-red spectroscopy, which demonstrated the formation of highly ordered pure crystalline nanoparticles with a relatively uniform size distribution of ∼10 nm (Au), ∼4 nm (Cu) and ∼3 nm (Pt), respectively. A broad range of organic ligands containing thiol or amine functional groups were attached to the nanoparticles to form continuous networks of nanoparticle-ligand nanoassemblies, which were characterised by scanning electron microscopy and x-ray photoelectron spectroscopy. The electrical resistance of the functional nanoassemblies deposited in the gap spacing of two microfabricated parallel Au electrodes patterned on silicon substrates ranged between tens of kΩ and tens of MΩ, which is suitable for use in many applications including (bio)chemical sensors, surface-enhanced Raman spectroscopy and molecular electronic rectifiers.

show abstract

Characterization of gold nanoparticle films: Rutherford backscattering spectroscopy, scanning electron microscopy with image analysis, and atomic force microscopy

Abstract: Enhanced semiconductor optical absorption via surface plasmon excitation in metal nanoparticles Applied Physics Letters 86, 063106 (2005);

Cited by 5 publications

References 16 publications

Evaluating Single-Cell DNA Damage Induced by Enhanced Radiation on a Gold Nanofilm Patch

Evaluating Single-Cell DNA Damage Induced by Enhanced Radiation on a Gold Nanofilm Patch

Novel deposition method for gold and platinum nanoparticles on silicon substrates utilizing poly (ethylene glycol) 6000 for MEIS analysis

Fabrication and characterisation of ligand-functionalised ultrapure monodispersed metal nanoparticle nanoassemblies employing advanced gas deposition technique

Contact Info

Product

Resources

About