2018
DOI: 10.1073/pnas.1805085115
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Characterization of gossypol biosynthetic pathway

Abstract: SignificanceCotton is an important crop, and terpenoids form the largest group of natural products. Gossypol and related sesquiterpene aldehydes in cotton function as phytoalexins against pathogens and pests but pose human health concerns, as cotton oil is still widely used as vegetable oil. We report the isolation and identification of four enzymes and the recharacterization of one previously reported P450. We are now close to the completion of the gossypol pathway, an important progress in agricultural and p… Show more

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Cited by 110 publications
(106 citation statements)
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“…As plant metabolites provide indispensable resources for human nutrition, energy and medicine (Butelli et al ., ; Chen et al ., ), dissecting the mechanism of metabolite biosynthesis in plants draws extreme interest (Saito and Matsuda, ; Cardoso et al ., ; Quadrana et al ., ; Zhao et al ., ; Fernie and Tohge, ; Perchat et al ., ; Tian et al ., ). In recent years, the rapid development of analysis approaches for metabolomes and multiomics techniques have greatly improved our knowledge of the naturally occurring metabolic variation in plants and its underlying genetic determinants in several species (Keurentjes et al ., ; Shang et al ., ; Sadre et al ., ; Tohge et al ., ; Wen et al ., ; Fernie and Tohge, ; Rai et al ., ; Westhues et al ., ; Xiao et al ., ; Zhu et al ., ).…”
Section: Discussionmentioning
confidence: 97%
“…As plant metabolites provide indispensable resources for human nutrition, energy and medicine (Butelli et al ., ; Chen et al ., ), dissecting the mechanism of metabolite biosynthesis in plants draws extreme interest (Saito and Matsuda, ; Cardoso et al ., ; Quadrana et al ., ; Zhao et al ., ; Fernie and Tohge, ; Perchat et al ., ; Tian et al ., ). In recent years, the rapid development of analysis approaches for metabolomes and multiomics techniques have greatly improved our knowledge of the naturally occurring metabolic variation in plants and its underlying genetic determinants in several species (Keurentjes et al ., ; Shang et al ., ; Sadre et al ., ; Tohge et al ., ; Wen et al ., ; Fernie and Tohge, ; Rai et al ., ; Westhues et al ., ; Xiao et al ., ; Zhu et al ., ).…”
Section: Discussionmentioning
confidence: 97%
“…High‐resolution P 2p XPS spectra show two narrow peaks located at 129.6 and 130.5 eV, which are assigned to elemental P 2p 3/2 and 2p 1/2 (Figure S7 b) . A weak and broad sub‐band for oxidized phosphorus species (P x O y ) is apparent at around 133.2 eV, which is also confirmed by the corresponding FT‐IR spectra (Figure S8) . These results imply that partial oxidation happened on the surface of BP/RP, in accordance with its low zeta potential value of −39.2 mV (Table S2).…”
Section: Figurementioning
confidence: 99%
“…), the presence of gossypol can contribute to pathogen defense (Sunilkumar et al, 2006;Mao et al, 2007). Gossypol is synthesized via the mevalonate (MVA) and gossypol pathways (Heinstein et al, 1970;Chen et al, 1995Chen et al, , 1996Liu et al, 1999;Luo et al, 2001;Tian et al, 2018). Although the MVA pathway that converts acetyl-CoA to farnesyl pyrophosphate (FPP) is found in almost all plants, the conversion of FPP to hemigossypol in the gossypol pathway is exclusive to Gossypium.…”
Section: Introductionmentioning
confidence: 99%