2023
DOI: 10.3390/pharmaceutics15112556
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Characterization of Graft Copolymers Synthesized from p-Aminosalicylate Functionalized Monomeric Choline Ionic Liquid

Aleksy Mazur,
Dorota Neugebauer

Abstract: An ionic liquid based on the monomeric choline, specifically [2-(methacryloyloxy)ethyl]-trimethylammonium chloride (TMAMA), underwent biofunctionalization through an ion exchange reaction with the model drug anion: p-aminosalicylate (PAS), a primary antibiotic for tuberculosis treatment. This modified biocompatible IL monomer (TMAMA/PAS) was subsequently copolymerized with methyl methacrylate (MMA) to directly synthesize the well-defined graft conjugates with regulated content of ionic fraction with PAS anions… Show more

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Cited by 2 publications
(2 citation statements)
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“…Linear copolymers based on TMAMA/Cl‾ (L1-L3) or TMAMA/PAS‾ (L4_PAS‾-L6_PAS‾) were synthesized as it was reported [56]. Graft copolymers based on TMAMA/PAS‾ (G1_PAS‾-G3_PAS‾) [64] or TMAMA/Cl‾ (G4-G6) [51] were synthesized Technology, 44-100 Gliwice, Poland; katarzyna.niesyto@polsl.pl (K.N. ); shadi.keihankhadiv@polsl.pl (S.K.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Linear copolymers based on TMAMA/Cl‾ (L1-L3) or TMAMA/PAS‾ (L4_PAS‾-L6_PAS‾) were synthesized as it was reported [56]. Graft copolymers based on TMAMA/PAS‾ (G1_PAS‾-G3_PAS‾) [64] or TMAMA/Cl‾ (G4-G6) [51] were synthesized Technology, 44-100 Gliwice, Poland; katarzyna.niesyto@polsl.pl (K.N. ); shadi.keihankhadiv@polsl.pl (S.K.…”
Section: Methodsmentioning
confidence: 99%
“…In this process, a low molecular weight initiator, ethyl 2-bromoisobutyrate, was applied. Moreover, graft copolymers were synthesized (Table 2) [51,64], wherein the chains of P(TMAMA-co-MMA) were grown by grafting from multifunctional macroinitiators containing 18-48% of 2-(2-bromoisobutyryloxy)ethyl methacrylate initiating units. Within each topological group of polymers, distinctions were made between polymers with Cl‾ (L1-L3 vs. G4-G6), polymers with PAS‾ directly introduced by the polymerization of pharmaceutically functionalized monomeric IL (L4_PAS‾-L6_PAS‾ vs. G1_PAS‾-G3_PAS‾), and polymers modified with PAS anions indirectly introduced by the post-…”
Section: Tmama-based Linear and Graft Copolymers As Drug Carriersmentioning
confidence: 99%