Characterization of hepatitis B virus DNA integration patterns in intrahepatic cholangiocarcinoma

Li, Mengge; Du, Min; Cong, Hui; Gu, Yuanyuan; Fang, Yuan; Jin, Li; Gan, Yu; Tu, Hong; Gu, Jinyang; Xia, Qiang

doi:10.1111/hepr.13580

Cited by 19 publications

(20 citation statements)

References 48 publications

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“…Based on the above results, we considered that the prognostic differences of ICC with different etiology had a strong correlation with its clinicopathological characteristics. Widespread epidemics with HBV infection in China increase integration of HBV gene fragments into liver cells, which contributes to ICC and also causes the HBV-ICC of China with highest distribution in the world [21][22][23]. In this study, the results showed that the prognosis of patients with HBV-ICC was better than those of Con-ICC and Stone-ICC subtypes.…”

Section: Discussionmentioning

confidence: 61%

Recurrence and Prognosis in Intrahepatic Cholangiocarcinoma Patients with Different Etiology After Radical Resection: A Multi-Institutional Study

Chen

et al. 2021

Preprint

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Objective We aimed to evaluate the prognosis and adjuvant chemotherapy (ACT) in intrahepatic cholangiocarcinoma (ICC) patients with different etiology after radical resection. Methods A total of 448 patients with ICC who underwent radical resection between 2010 and 2018 at ten Chinese tertiary hospitals were analyzed in the study. These patients were divided into conventional ICC (Con-ICC, n=261, 58.2%), hepatitis B virus ICC (HBV-ICC, n=102, 22.8%) and hepatolithiasis (Stone-ICC, n=85,19.0%) subtypes according to different etiology. Propensity score matching (PSM) was conducted to mitigate the baseline differences between related two subtypes. Results Univariate and multivariate analysis showed that different etiology was a prognostic factor for overall survival and relapse-free survival, and different etiology was an independent risk factor for overall survival in ICC patients, respectively (P<0.05). In addition, there was a statistical difference for overall survival in early recurrence patients among the three etiological subtypes (P<0.05). After PSM, the overall survival of patients with Stone-ICC was worse than those of Con-ICC and HBV-ICC subtypes (P<0.05), while the relapse-free survival of patients with Stone-ICC was equivalent to patients with Con-ICC and HBV-ICC (P>0.05). In Stone-ICC patients, the median overall survival was 16.0 months and 29.7 months, and the median relapse-free survival was 9.0 months and 20.0 months for non-ACT and ACT patients, respectively (P<0.05). Conclusion The prognosis of Stone-ICC patients was significantly worse than those of Con-ICC and HBV-ICC patients. Interestingly, postoperative adjuvant chemotherapy can improve the prognosis of Stone-ICC patients effectively.

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Section: Discussionmentioning

confidence: 61%

Recurrence and Prognosis in Intrahepatic Cholangiocarcinoma Patients with Different Etiology After Radical Resection: A Multi-Institutional Study

Chen

et al. 2021

Preprint

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“…Overall, 47.5% of integration sites were within gene bodies, all intronic. The only recurrently integrated gene was long non-coding RNA LINC00486, which has been identified as a recurrent hepatitis B virus integration site in the liver cancer intrahepatic cholangiocarcinoma 30 .…”

Section: Resultsmentioning

confidence: 99%

Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes

et al. 2022

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Although recent work has described the microbiome in solid tumors, microbial content in hematological malignancies is not well-characterized. Here we analyze existing deep DNA sequence data from the blood and bone marrow of 1870 patients with myeloid malignancies, along with healthy controls, for bacterial, fungal, and viral content. After strict quality filtering, we find evidence for dysbiosis in disease cases, and distinct microbial signatures among disease subtypes. We also find that microbial content is associated with host gene mutations and with myeloblast cell percentages. In patients with low-risk myelodysplastic syndrome, we provide evidence that Epstein-Barr virus status refines risk stratification into more precise categories than the current standard. Motivated by these observations, we construct machine-learning classifiers that can discriminate among disease subtypes based solely on bacterial content. Our study highlights the association between the circulating microbiome and patient outcome, and its relationship with disease subtype.

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“…91,92 In the Chinese study, no PCR products specific for S and C genes were observed in either ICC tissues or non-tumour tissues of four HBV-unrelated cases. 93…”

Section: Obi In Patients With Icc and Cryptogenic Liver Diseasementioning

confidence: 99%

Occult hepatitis B virus infection in hepatitis C virus negative chronic liver diseases

Franzè

Pollicino

Raimondo

et al. 2022

Liver International

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Data concerning the prevalence of hepatitis B virus (HBV) occult infection (OBI) varies greatly in the different studies according to the sensitivity and specificity of the diagnostic approaches and the HBV prevalence in the different populations examined. The clinical implications of OBI are still debated. While the impact of OBI in HBV transmission as well as in HBV reactivation under immunosuppression are well established, the role of OBI in liver disease and hepatocellular carcinoma (HCC) development are still not definitively elucidated. It has been hypothesized that OBI might contribute to worsening the liver disease course when other causes of liver damage co‐exist. Furthermore, much evidence suggests a role of OBI in the hepato‐carcinogenesis processes through both indirect and direct oncogenic mechanisms that might favour HCC development. Data on the OBI clinical implications mainly come from studies performed in patients with hepatitis C virus (HCV) infection. However, HCV prevalence has dramatically fallen in the past years also because of the advent of specific and highly effective direct acting antivirals, with a consequent abrupt change of the worldwide scenario of chronic liver disease. Information about OBI prevalence and possible clinical impact in non‐HCV‐related liver disease are fragmentary, and the objective of this review is to critically summarize the available data in this field.

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Characterization of hepatitis B virus DNA integration patterns in intrahepatic cholangiocarcinoma

Cited by 19 publications

References 48 publications

Recurrence and Prognosis in Intrahepatic Cholangiocarcinoma Patients with Different Etiology After Radical Resection: A Multi-Institutional Study

Recurrence and Prognosis in Intrahepatic Cholangiocarcinoma Patients with Different Etiology After Radical Resection: A Multi-Institutional Study

Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes

Occult hepatitis B virus infection in hepatitis C virus negative chronic liver diseases

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