Characterization of host-parasite interactions during the experimental Trichinella spiralis infection in pigs

Abstract

The aim of the present experiment was to assess the clinical, haematological, biochemical and immunological responses of pigs experimentally infected with Trichinella spiralis. One group of 6 pigs was infected with 1500 larvae/kg body weight and one group of 7, was maintained as control. The highest larval density was in the diaphragm (504.3 ± 8.2). During the experimental T. spiralis infection in pigs, increased values of total granulocyte number, eosinophils, blood glucose, K+ concentration, CK, ALT, AST and ALP were registered in different stages of infection. A slight increase of the phagocytic activity was registered 14 days p.i., in the infected group. Significantly increased values in lymphocyte activity, in infected group, was observed 30 and 60 days p.i. comparative with control. The specific IgG antibodies were detectable by ELISA at 14 days p.i. The results obtained in this study provide a better understanding about complete interactions occurring during Trichinella infection in pigs.

Blood glucose, insulin and glycogen profiles in Sprague-Dawley rats co-infected with Plasmodium berghei ANKA and Trichinella zimbabwensis

“…In high infection groups, peak blood glucose concentration was recorded 35–49 days post infection ( La Grange & Mukaratirwa, 2014 ). A significant increase in blood glucose concentration 30 days post infection was also reported in pigs ( Oltean et al, 2012 ) which coincided with trichinella larvae being established in the striated muscles of host.…”

Preliminary insights on the metabolomics of Trichinella zimbabwensis infection in Sprague Dawley rats using GCxGC-TOF-MS (untargeted approach)

“…The study by Sukhdeo and Mettrick (1984) reported that the reduced absorptive capacity of the intestine cannot be a leading cause, since it has been reported that during moderate infection, Trichinella infection does not affect glucose uptake by intestine. However, a study by Oltean et al (2012) reported an increase in the blood glucose concentration of Trichinella spiralisinfected pigs 30 days post-infection comparative with uninfected ones. Therefore, this suggests that trichinellosis has an influence in glucose metabolism.…”

Differences in Immune Characteristics and Related Gene Expression in Spleen among Ningxiang, Berkshire Breeds and Their Hybrid Pigs

“…The levels of plasma ALB (albumin), and ALT (alanine aminotransferase), in Berkshires are significantly higher than those in Ningxiang pigs and F 1 offspring. The activity of ALT increases in pigs during bacterial infection, which helps to enhance disease resistance [27]. The increase in ALB levels can enhance the immunity of piglets [28].…”