Characterization of Human Papillomavirus Infection, P53 and Ki-67 Expression in Cervix Cancer of Mozambican Women

Distribution of HPV infection and tumour markers in cervical intraepithelial neoplasia from cone biopsies of Mozambican women

“…The strong causal association between cervical carcinoma and infection by human papillomavirus (HPV) is well established, and it was recently proposed that HPV infection is a necessary cause of cervical cancer development. 1 Both our group, 2 and that of Castellsague et al, 3 have previously described the profile of HPV infection in Mozambican women. 2 3 In both studies, the types of HPV identified coincided with those previously described in other sub-Saharan countries, with a high prevalence of HPV types 16,31,33,35, and 58.…”

“…2 3 In both studies, the types of HPV identified coincided with those previously described in other sub-Saharan countries, with a high prevalence of HPV types 16,31,33,35, and 58. [2][3][4][5][6] With the improvement of methods to detect HPV at the molecular level there is increasing evidence of the presence of HPV in cervical intraepithelial neoplasia (CIN) lesions. 7 8 The detection of multiple infections has also increased, probably because of the higher sensitivity of the techniques that are currently used.…”

Human papillomavirus (HPV) infection: a Mozambique overview

“…Those concerning prevalence and risk factors, attest a high prevalence ranging from 40 to 96 % depending on the considered population, and listed the most common and known risk factors, such as multiple sexual partners, reproductive age and other STD, including HIV [1,54,58]. Studies characterizing HPV infection, confirmed the presence of high-risk genotypes in patients with cervical cancer and showed no association between HPV and P53 and/or Ki-67 that are instead associated with invasive cervix carcinomas, mainly of the squamous keratinizing histotype [12,57,13,17]. Too little is being done to prevent transmission of HPV and only few studies have been conducted regarding vaccination, effectiveness and cost/benefit analysis [47,11,16].…”

Оптимизация Современных Подходов В Лечении Гинекологического Рака Основных Локализаций

“…Кроме того, имеются данные о том, что пролиферативная активность эпителиальных клеток при предраковых по-ражениях шейки матки зависит от наличия ВПЧ ВКР [11]. В то же время есть исследования, не обнаруживающие такой зависимости и указывающие, что пролиферативная активность при РШМ может варьировать в широких пре-делах, отличаясь у разных больных более чем в 10 раз [12]. Ряд авторов предлагает определять экспрессию PCNA, Ki-67 и p16ink4a, служащих суррогатными маркерами экспрессии вирусных онкогенов, с целью предсказывания активности вирусных генов Е6 / Е7 [13,14,15].…”

“…В других работах значи-мость COX-2 как фактора прогноза отрицается [18]. Одни авторы обнаруживают корреляционную связь между экс-прессией COX-2 и ВПЧ, утверждая, что онкобелки Е6 и Е7 увеличивают транскрипцию COX-2 через EGFR-сигналь-ный путь, другие ученые указывают на отсутствие связи экспрессии COX-2 с наличием ВПЧ-инфекции [12,19].…”