Characterization of hyaluronic acid extracted from Liparis tessellatus eggs grafted with phenolic acids and nisin

Nguyen, Thanh Tri; Neri, Therese Ariane; Choi, Byeong-Dae

doi:10.1016/j.ijbiomac.2020.04.137

Cited by 11 publications

(5 citation statements)

References 23 publications

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“… 30 For blank micelles, the band at 1048.92 cm −1 could be due to the C–O–C stretching vibration of HA. 31 After encapsulation of CUR in micelles, the characteristic peaks of CUR at 3509.36 cm −1 , 1629.37 cm −1 and 962.48 cm −1 were disappeared. This change indicated that there might be hydrogen bond interactions among the groups of CUR and the OHA.…”

Section: Resultsmentioning

confidence: 96%

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Niu¹,

Yuan²,

Zhang³

et al. 2022

IJN

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Background The poor skin permeation and deposition of topical therapeutic drugs is a major issue in topical drug delivery, improving this issue is conducive to improving the topical therapeutic effect of drugs. Methods In this study, octadecylamine modified hyaluronic acid (OHA) copolymer was synthesized by amide reaction technique to prepare curcumin (CUR)-loaded micelles (CUR-M) for topical transdermal administration. CUR-M was successfully prepared by dialysis, and the formulation was evaluated for particle size, zeta potential, surface morphology, entrapment effciency (EE%), drug loading (DL), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and the in vitro drug release. Additionally, in vitro skin permeation and retention, in vivo topical analgesic and anti-inflammatory activity, and skin irritation were assessed. Results The mean drug loading (DL), drug entrapment efficiency (EE), hydrodynamic diameter and zeta potential of CUR-M were 8.26%, 90.86%, 165.64 nm and −26.85 mV, respectively. CUR-M was characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), it was found that there was an interaction between CUR and OHA, and CUR existed in CUR-M in an amorphous form. CUR-M exhibited sustained release in 48 h and good stability at 4 °C for 21days. CUR-M could significantly increase the skin penetration and retention of CUR and had better analgesic and anti-inflammatory activities in vivo when compared with CUR solution. Hematoxylin-eosin staining results revealed that the transdermal penetration mechanism of CUR-M might be related to the hydration of stratum corneum by HA. In addition, CUR-M showed no skin irritation to mouse skin. Conclusion CUR-M might be a promising and safe drug delivery system for the treatment of topical diseases.

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Section: Resultsmentioning

confidence: 96%

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Niu¹,

Yuan²,

Zhang³

et al. 2022

IJN

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“…S3, ESI†). Furthermore, the peaks at 1650 cm −1 and 1560 cm −1 may be due to the CO stretching vibrations of the amide I and II bonds, 36 which proved that PDPA was grafted on the GO surface by the amide bond. Compared with the infrared spectrum of quercetin, 37 GO–PDPA–CHI@QU had same peaks of QU at 1319 cm −1 related to the bending of C–OH phenol and 1610 cm −1 related to the vibration of the benzene ring skeleton.…”

Section: Resultsmentioning

confidence: 96%

Dual-sensitive GO-based self-assembly for the delivery of a hydrophobic anti-cancer drug

Liu

Chen

et al. 2022

New J. Chem.

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“…Phenolic acids (GA, CA, and FA) and nisin were grafted onto HALTE as described by Nguyen et al (2020). Reaction mixtures for each phenolic acid were prepared by adding a 30fold molar excess of GA, CA, and FA to HALTE (3 mg/mL) solutions.…”

Section: Grafting Of Phenolic Compounds and Nisin Onto Haltementioning

confidence: 99%

“…Finally, the dialysates were lyophilized to obtain phenolic acid-grafted HAs, which were labeled GA-g-HALTE, CA-g-HALTE, FA-g-HALTE and Nisin-g-HALTE. The grafting ratios were measured, and their structure were determined by Fourier transform infrared, and proton nuclear magnetic resonance (Nguyen et al, 2020).…”

Section: Thanh Tri Nguyen and Byeong-dae Choimentioning

confidence: 99%

Antioxidant and anti-inflammatory activities of phenolic compounds grafted with hyaluronic aicd derived from Liparis tessellatus eggs

Nguyen¹,

Choi²

2022

Fish Aquat Sci

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Hyaluronic acid from Liparis tessellatus eggs (HALTE) was grafted with caffeic acid (CA-g-HALTE), ferulic acid (FA-g-HALTE), gallic acid (GA-g-HALTE), and nisin (Nisin-g-HALTE) and investigated for their anti-inflammatory and antioxidant potential in lipopolysaccharides-stimulated RAW 264.7 mouse macrophages. Nitric oxide (NO) generation and prostaglandin E 2 activity were measured after treatment with the grafted HALTE samples. All grafted HALTE samples exhibited more antioxidant activity against 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radicals than 2,2-diphenyl-1-picrylhydrazyl radicals. Nisin-g-HALTE showed the least antioxidant activity. Additionally, the NO assay results showed that all grafted samples had no cytotoxic effect on RAW 264.7 macrophages and reduced macrophage activity after treatment. The most effective concentrations of CA-g-HALTE and FAg-HALTE were found to be above 100 μg/mL. Increased sample concentration resulted in increased activity except with Nisin-g-HALTE at 100 μg/mL. CA-g-HALTE, FA-g-HALTE, GA-g-HALTE, and Nisin-g-HALTE were found to have antioxidant and anti-inflammatory potential, which can be further explored for use in food, cosmetic, nutraceutical, and biomedical applications.

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Characterization of hyaluronic acid extracted from Liparis tessellatus eggs grafted with phenolic acids and nisin

Cited by 11 publications

References 23 publications

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Dual-sensitive GO-based self-assembly for the delivery of a hydrophobic anti-cancer drug

Antioxidant and anti-inflammatory activities of phenolic compounds grafted with hyaluronic aicd derived from Liparis tessellatus eggs

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