Characterization of Hydrogen Bonding between Selected Barbiturates and Polyethylene Glycol 4000 by IR Spectral Analysis

Chang, B.-L.; Nuessle, Noel O.; Haney, W.G.

doi:10.1002/jps.2600641110

Cited by 14 publications

(2 citation statements)

References 23 publications

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“…It has been reported that in the crystalline state, PEO polymer chains exist as two helical structures containing seven CH 2 CH 2 O units. 33 A significant amount of drug might be incorporated in this particular helical interstitial space of the PEO crystal during blend preparation. In addition, the linear chains of PEO molecules have extremely high-segmental mobility due to the ether linkages, which allows for a very flexible backbone compared to that of HPC molecules.…”

Section: Effect Of Hot-melt Processing Conditions On Thc Stabilitymentioning

confidence: 99%

Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing

Munjal

Stodghill

ElSohly

et al. 2006

Journal of Pharmaceutical Sciences

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Section: Effect Of Hot-melt Processing Conditions On Thc Stabilitymentioning

confidence: 99%

Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing

Munjal

Stodghill

ElSohly

et al. 2006

Journal of Pharmaceutical Sciences

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“…Formation of a drug-polymer solid dispersion in hot-melt extruded dosage forms has been reported (Aitken-Nichol et al, 1996;Zhang et al, 2000). Complexation between drug and polymer may also contribute to the formation of a solid solution (Chang et al, 1975). Solid solutions containing the drug and an amorphous polymer are generally regarded as interstitial solid solutions where drug molecules occupy the interstitial space between the polymer chains.…”

mentioning

confidence: 99%

Pharmaceutical Applications of Hot-Melt Extrusion: Part I

Crowley¹,

Zhang²,

Repka

et al. 2007

Drug Development and Industrial Pharmacy

654

365

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Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.

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Pharmaceutical Sciences—1975: Literature Review of Pharmaceutics II∆∆Editor’s note: Part I of this article appeared in the July 1976 issue of the Journal of Pharmaceutical Sciences

Goodhart¹,

Eichman

1976

Journal of Pharmaceutical Sciences

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Characterization of Hydrogen Bonding between Selected Barbiturates and Polyethylene Glycol 4000 by IR Spectral Analysis

Cited by 14 publications

References 23 publications

Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing

Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing

Pharmaceutical Applications of Hot-Melt Extrusion: Part I

Pharmaceutical Sciences—1975: Literature Review of Pharmaceutics II∆∆Editor’s note: Part I of this article appeared in the July 1976 issue of the Journal of Pharmaceutical Sciences

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