Characterization of Immune Cell Infiltration Into Canine Intracranial Meningiomas

Boozer, Lindsay; Davis, Tom; Borst, Luke B.; Zseltvay, K. M.; Olby, Natasha J.; Mariani, Christopher L.

doi:10.1177/0300985811417249

Cited by 23 publications

(21 citation statements)

References 68 publications

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“…Several “vaccine”‐based approaches have been developed including vaccination with patient dendritic cells “primed” with tumor antigen, tumor peptides, heat shock proteins, and autologous and allogenic tumor cell preparations 203, 230, 231, 232, 233. Limited information is available defining immune cell activity in canine brain tumors, but preliminary studies defining immune cell infiltration in canine meningiomas,234 and the ability of Flt3L to stimulate canine dendritic cells,235 suggest that there will be many similarities to human tumors. Translational studies in dogs with glioma using tumor cell lysate/CpG vaccines, combined with postsurgical intracavitary delivery of IFNg via an adenoviral vector, have demonstrated the feasibility of immunotherapy in dogs, with tumor‐reactive IgG and CD8+ T cells being documented in 1 reported case 206, 236.…”

Section: Novel Therapiesmentioning

confidence: 99%

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Dickinson

2014

Veterinary Internal Medicne

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Intracranial neoplasia is a common clinical condition in domestic companion animals, particularly in dogs. Application of advances in standard diagnostic and therapeutic modalities together with a broad interest in the development of novel translational therapeutic strategies in dogs has resulted in clinically relevant improvements in outcome for many canine patients. This review highlights the status of current diagnostic and therapeutic approaches to intracranial neoplasia and areas of novel treatment currently in development.

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Section: Novel Therapiesmentioning

confidence: 99%

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Dickinson

2014

Veterinary Internal Medicne

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“…In the brain of different species including humans and laboratory rodents TLR4 expression has been reported in microglia and astrocytes with microglia exhibiting higher expression rates [27]. In the canine brain TLR4 expression has so far only been analyzed in tissue surrounding intracranial meningiomas [28]. The authors described scattered TLR4-expressing macrophages in the area of the tumor-brain interface [28].…”

Section: Discussionmentioning

confidence: 99%

Molecular alterations of the TLR4-signaling cascade in canine epilepsy

et al. 2020

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Background: Cumulating evidence from rodent models points to a pathophysiological role of inflammatory signaling in the epileptic brain with Toll-like receptor-4 signaling acting as one key factor. However, there is an apparent lack of information about expression alterations affecting this pathway in canine patients with epilepsy. Therefore, we have analyzed the expression pattern of Toll-like receptor 4 and its ligands in brain tissue of canine patients with structural or idiopathic epilepsy in comparison with tissue from laboratory dogs or from owner-kept dogs without neurological diseases. Results: The analysis revealed an overexpression of Toll-like receptor-4 in the CA3 region of dogs with structural epilepsy. Further analysis provided evidence for an upregulation of Toll-like receptor-4 ligands with high mobility group box-1 exhibiting increased expression levels in the CA1 region of dogs with idiopathic and structural epilepsy, and heat shock protein 70 exhibiting increased expression levels in the piriform lobe of dogs with idiopathic epilepsy. In further brain regions, receptor and ligand expression rates proved to be either in the control range or reduced below control levels. Conclusions: Our study reveals complex molecular alterations affecting the Toll-like receptor signaling cascade, which differ between epilepsy types and between brain regions. Taken together, the data indicate that multitargeting approaches modulating Toll-like receptor-4 signaling might be of interest for management of canine epilepsy. Further studies are recommended to explore respective molecular alterations in more detail in dogs with different etiologies and to confirm the role of the pro-inflammatory signaling cascade as a putative target.

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“…Moreover, immunohistochemistry gave no evidence to suggest that the cells were neoplastic cells from the ependym. Boozer et al (2012) investigated the presence of a variety of immune cell subsets within canine intracranial meningiomas. They demonstrated that immune cell infiltration was evident in all samples, with a predominance of CD3 + T cells.…”

Section: Discussionmentioning

confidence: 99%

Gliomatosis of the spinal cord in a cat: a case report

Jelínek¹

2013

Vet. Med. - Czech

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Gliomatosis cerebri situated in the thoracolumbar and lumbosacral segments of the spinal cord was diagnosed in a Persian 10.5-year old tom cat. Clinical manifestation consisted of rump ataxy, weakened posture in the hind limbs, paraparesis, weakened spinal reflexes, no spinal hyperaesthesia or pain, and hypotonia of the urinary bladder. Magnetic resonance imaging revealed a diffuse hyperintense signal in the thoracolumbar junction and in lumbosacral segments (L6-S1) of the spinal cord. Normal size, form and colour of the spinal cord were apparent at autopsy; however, changes in grey matter shape were recorded on some transversal sections of the spinal cord. Dense, diffuse infiltration of the grey matter and surrounding white matter by glia-like neoplastic cells was histologically demonstrated. Immunohistochemical examination did not enable specification of the origin of the neoplastic cells but their neuroectodermal histogenesis can be assumed. On the basis of MRI, histological and immunohistochemical examinations gliomatosis of the spinal cord was diagnosed.Keywords: feline; medulla; neoplasia; clinic; pathology Gliomatosis cerebri is a rare neoplasia both in humans and animals. Maxie and Youssef (2007) and Vandevelde et al. (2012) have described gliomatosis as a widespread diffuse infiltrating disease of dogs, predominantly of brachycephalic breeds, characterised by an infiltrative cell type more reminiscent of astrocytes than of the formation of a distinct tumour mass. The infiltrates involve the hemispheric lobes, cerebellum and brainstem, often bilaterally but assymetrically. Discontinuous areas of gliomatosis have also been described in the spinal cord. There is no tumour mass, rather a diffuse enlargement of the affected regions; the neoplastic cells insinuate among normal structures that remain intact with only slight damage to axons and neurons. The tumour cells usually have elongated, enlarged, often twisted mildly hyperchromic nuclei without detectable cytoplasm. Case descriptionThe owner of an indoor/outdoor Persian 10.5-year old tom cat reported that his cat suddenly could not jump on the armchair and that his hind limbs appeared week. Over the next 12 days the owner observed that some attempts of similar jumps were successful and some of them not. In this period micturition habits also changed. Instead of the former two or three urinations per day, the frequency increased up to nine but the quantity of urine markedly decreased per each micturition. Seven days after the onset of the motion disorder, biochemical and haematological examinations were carried out. These examinations revealed only mild monocytosis (7%) and mild renal azotaemia (creatinine 157 µmol/l). All remaining haematological and biochemical parameters were within the physiological range. Twelve days after appearance of the first symptoms, the cat could not rise to his hind limbs and was referred to the veterinary clinic for a specialized examination.

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Characterization of Immune Cell Infiltration Into Canine Intracranial Meningiomas

Cited by 23 publications

References 68 publications

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Molecular alterations of the TLR4-signaling cascade in canine epilepsy

Gliomatosis of the spinal cord in a cat: a case report

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