Characterization of In Vivo Biomechanical Properties in Macular Corneal Dystrophy

Feizi, Sepehr; Karjou, Zahra; Abbasi, Hamed; Javadi, Mohammad Ali; Azari, Amir A.

doi:10.1016/j.ajo.2020.03.003

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…Studies reported changes in the corneal biomechanical parameters in different types of corneal dystrophies [ 9 , 10 , 11 ]. Kamiya et al mentioned no difference in the biomechanical parameters evaluated using an ocular response analyzer (ORA) between GCD and normal eyes [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Stress-Strain Index and Corneal Biomechanics in Granular Corneal Dystrophy

Heidari

Momeni‐Moghaddam

Jadidi

et al. 2022

JCM

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Background: The aim of this study was to assess stress-strain index (SSI) and corneal biomechanical parameters in eyes with granular corneal dystrophy (GCD). Methods: This case-control study included 12 eyes of 12 patients with GCD (mean age 45.2 ± 18.7 years) and 20 eyes of 20 healthy individuals (mean age 54.4 ± 3.8 years). In addition to SSI, dynamic corneal response (DCR) parameters were assessed at the first and second applanation, including length (AL1, AL2), velocity (AV1, AV2), time (AT1, AT2), and deformation amplitude (DA A1, DA A2), and at the highest concavity (HC) phase, including DA, peak distance (PD), radius (HCR), and DA ratio (DAR 1 and 2 mm), by Corvis ST. Central corneal thickness (CCT) and biomechanically corrected intraocular pressure (bIOP) were considered covariates in comparing DCR parameters between the two groups. Results: SSI was statistically significantly lower in eyes with GCD than in normal eyes (p = 0.04). The corneal velocity towards the first applanation was 0.02 m/s faster in the GCD eyes AV1 (0.15 ± 0.02 vs. 0.13 ± 0.02 m/s, p < 0.001) and IR (7.48 ± 1.01 vs. 6.80 ± 1.22 mm, p = 0.003) parameters were significantly higher in the GDC group, while AT1 (7.33 ± 0.66 vs. 7.47 ± 0.36 ms, p = 0.002) and HCR (7.42 ± 0.76 vs. 8.20 ± 1.08 mm, p = 0.014) were significantly lower in the normal group. Conclusions: GCD led to a change in biomechanical properties of the cornea. SSI refers to fewer stiff corneas in GDC than normal.

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Section: Introductionmentioning

confidence: 99%

Changes in Stress-Strain Index and Corneal Biomechanics in Granular Corneal Dystrophy

Heidari

Momeni‐Moghaddam

Jadidi

et al. 2022

JCM

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Assessment of the specificity of corvis biomechanical index-laser vision correction (CBI-LVC) in stable corneas after phototherapeutic keratectomy

Vinciguerra,

Cancian,

Ambrósio

et al. 2023

Int Ophthalmol

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Purpose: The CBI-LVC is a biomechanical index to detect ectasia in post-refractive surgery patients (PRK, LASIK, SMILE). This study aims to evaluate the distribution of the CBI-LVC in stable patients who underwent Phototherapeutic Keratectomy (PTK) compared to PRK patients. Methods: Patients who underwent PRK and PTK performed between 2000 and 2018in Humanitas Research Hospital, Rozzano, Milan, Italy and remained stable for at least four years post-surgery were included. All eyes were examined with the Corvis ST (Oculus, Germany), whose output allows the calculation of the CBI-LVC. The distribution and speci city of the CBI-LVC in the two populations were estimated using a Wilcoxon Mann-Whitney test and compared.Results: 175 eyes of 148 patients were included (85 eyes of 50 PTK patients and 90 eyes of 90 PRK patients). The distribution of CBI-LVC in the two groups showed a minor difference, with a median value in PRK patients of 0.000 (95% CI 0.000; 0.002) and 0.008 (95% CI 0.000; 0.037) in PTK patients (Mann-Whitney U test p = 0.023). The statistical analysis showed that the CBI-LVC provided a speci city of 92.22% in the PRK group, while in the PTK group it was 82.35%. Nevertheless, this difference was not statistically signi cant (Chi-squared test with Yates, p = 0.080).Conclusion: CBI-LVC provided similar speci city in stable PTK patients compared to those who underwent PRK. These results suggest that the CBI-LVC could be a useful tool to aid corneal surgeons in managing PTK patients.

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Reply to Comment on: Characterization of In Vivo Biomechanical Properties in Macular Corneal Dystrophy

Feizi¹,

Karjou²,

Abbasi³

et al. 2020

American Journal of Ophthalmology

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Characterization of In Vivo Biomechanical Properties in Macular Corneal Dystrophy

Cited by 6 publications

References 26 publications

Changes in Stress-Strain Index and Corneal Biomechanics in Granular Corneal Dystrophy

Changes in Stress-Strain Index and Corneal Biomechanics in Granular Corneal Dystrophy

Assessment of the specificity of corvis biomechanical index-laser vision correction (CBI-LVC) in stable corneas after phototherapeutic keratectomy

Reply to Comment on: Characterization of In Vivo Biomechanical Properties in Macular Corneal Dystrophy

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