2024
DOI: 10.1002/jmv.29348
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Characterization of integrated hepatitis B virus DNA harboring pre‐S mutations in hepatocellular carcinoma patients with ground glass hepatocytes

Yih‐Ping Su,
Selena Y. Lin,
Ih‐Jen Su
et al.

Abstract: Ground glass hepatocytes (GGHs) have been associated with hepatocellular carcinoma (HCC) recurrence and poor prognosis. We previously demonstrated that pre‐S expression in some GGHs is resistant to current hepatitis B virus (HBV) antiviral therapies. This study aimed to investigate whether integrated HBV DNA (iDNA) is the primary HBV DNA species responsible for sustained pre‐S expression in GGH after effective antiviral therapy. We characterized 10 sets of micro‐dissected, formalin‐fixed‐paraffin‐embedded, and… Show more

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