Characterization of interfacial strength of layered powder-compacted solids

Kottala, Niranjan; Abebe, Admassu; Sprockel, Omar; Akseli, Ilgaz; Nikfar, Faranak; Cuitiño, Alberto M.

doi:10.1016/j.powtec.2012.12.028

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…As a result, caution must be exercised to enable the design of a robust product and process. 19 Bilayer tablets can be thought of as two single-layer tablets compacted into one but in practicality there are several manufacturing problems associated.…”

Section: Challenges Involved In Manufacturing Of Bilayer Tabletmentioning

confidence: 99%

Recent Advancement and Challenges in Bilayer Tablet Technology: An Overview

NIZAMI¹,

MALVIYA²

2022

Curr. Res. Pharm. Sci.

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Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermined release of two drugs in combination, separating two incompatible substances, and sustained-release tablets with one layer serving as the loading dose and the second layer serving as the maintenance dose. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology is resource-intensive. A thorough selection of excipients and manufacturing conditions for each technical stage is also required. The purpose of this paper is to summarize the state of art in bilayer tablet technology and to highlight the difficulties encountered during bilayer tablet manufacture, as well as the possible solutions for these obstacles. KEYWORDS: Bilayer tablet, Conventional release, Controlled release, Sustained release, Maintenance dose

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Section: Challenges Involved In Manufacturing Of Bilayer Tabletmentioning

confidence: 99%

Recent Advancement and Challenges in Bilayer Tablet Technology: An Overview

NIZAMI¹,

MALVIYA²

2022

Curr. Res. Pharm. Sci.

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“…Layer expansion occurs when moisture is absorbed by porous compacts and/or particles. Any change in layer size weakens the contact between the layers, which might lead to timedependent delamination 24 . It was recommended that the materials be pre-conditioned to ensure that they are in equilibrium with the moisture content of the air in the manufacturing area, and that the compacts be packaged in airtight, moisture-resistant blisters.…”

Section: Environmental Conditionmentioning

confidence: 99%

The Challenges of Producing Bilayer Tablet: A Review

Singh

Das

Gupta

et al. 2021

J. Drug Delivery Ther.

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Bilayer tablets are the advanced form of conventional immediate release tablet system, which consist of either two similar or different drugs combined in a single dose for effective treatment of the disease improving patient compliance. However, the multilayer tablet technology is demanding It also necessitates meticulous selection of excipients and manufacturing conditions for each technological stage. The aim of this review is to provide an outline of state of art of bilayer tablet technology and emphasise the difficulties experienced during Bilayer tablet manufacturing along with its intend solutions for these challenges. Keyword: Bilayer tablet, Conventional release, Challenges encountered, Compliance.

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“…Another aspect of the multi-layer tablet compression is the ratio of the layers and the sequence of their arrangement for the same purpose of reducing the potential of interlayer delamination or intralayer capping [8,13,37,43]. Most commonly, bilayer tablets are prepared so that the weight ratio of the layers is 1:1 or 1:2.…”

Section: Ratio and The Sequence Of The Layersmentioning

confidence: 99%

“…Thus, there is no possibility to avoid problems associated with applying higher weight upon the first layer of tablet [8]. Still, Kottala et al [43] has prepared bilayer tablets with methyl cellulose and lactose at ratios 1:1, 1:3, 3:1, and concluded that neither the ratio nor the used materials had any significant influence on the breaking force.…”

Section: Ratio and The Sequence Of The Layersmentioning

confidence: 99%

Challenges in technology of bilayer and multi-layer tablets: a mini-review

Blicharski

Świąder

Serefko

et al. 2019

Current Issues in Pharmacy and Medical Sciences

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Bilayer and multi-layer tablets are enjoying growing popularity among original drug and generic product manufacturers. Multi-layer tablets have many key benefits compared to classic immediate-release tablets. The use of such solid oral dosage forms simplifies dosing regimens in combination therapy, and thus improves patient compliance. However, the technology of multilayer tablets is demanding and requires precise choice of excipients and production parameters with regard to each technological step. The main benefits of multi-layer tablets, certain aspects of their production and the challenges encountered during the compression process are reviewed in this paper.

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Characterization of interfacial strength of layered powder-compacted solids

Cited by 11 publications

References 17 publications

Recent Advancement and Challenges in Bilayer Tablet Technology: An Overview

Recent Advancement and Challenges in Bilayer Tablet Technology: An Overview

The Challenges of Producing Bilayer Tablet: A Review

Challenges in technology of bilayer and multi-layer tablets: a mini-review

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