Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm

Nakanuma, Yasuni; Kakuda, Yuko; Uesaka, Katsuhiko; Miyata, Takashi; Yamamoto, Yusuke; Fukumura, Yuki; Sato, Yasunori; Sasaki, Motoko; Harada, Kenichi; Takase, Masaru

doi:10.1016/j.humpath.2015.12.022

Cited by 47 publications

(52 citation statements)

References 28 publications

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“…The strong relationship with high immunoexpression of CK20, MUC2 and CDX2 supported intestinal differentiation in biliary‐IPMN. Recently, Nakanuma et al . described 52 IPNBs in their series, and recognized that ~70% of IPNBs can resemble or be identical to IPMN in terms of histopathological and biological features, whereas the others were different from IPMN.…”

Section: Discussionmentioning

confidence: 99%

RNF43 mutation frequently occurs with GNAS mutation and mucin hypersecretion in intraductal papillary neoplasms of the bile duct

et al. 2017

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Section: Discussionmentioning

confidence: 99%

RNF43 mutation frequently occurs with GNAS mutation and mucin hypersecretion in intraductal papillary neoplasms of the bile duct

et al. 2017

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“…Nakanuma et al. examined IPNBs arising in the intrahepatic and extrahepatic bile ducts, and reported that approximately half of IPNBs showed similar histopathological features to IPMNs, while the other half appeared not to be similar to IPMNs. IPNBs resembling pancreatic IPMNs typically developed in the intrahepatic bile duct, and the gastric type was the most common phenotype, followed by the intestinal and oncocytic types.…”

Section: Review Of the Literature Regarding The Histological Heterogementioning

confidence: 99%

A statement by the Japan‐Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage

Nakanuma

Jang

Fukushima

et al. 2018

J Hepato Biliary Pancreat

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103

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Intraductal papillary neoplasm of bile duct (IPNB) was described as a preinvasive neoplastic lesion of the biliary tract in the 2010 World Health Organization (WHO) classification. Although a number of studies have since been conducted on IPNBs, controversy remains, particularly regarding the standardization of its definition. Meetings by Japanese and Korean expert pathologists were held twice to resolve the pathological diagnostic aspects of IPNB. Through round-table discussions and histological reviews, we reached the common understanding that IPNBs diagnosed according to the criteria of WHO 2010 are characterized by intraductal predominant papillary or villous biliary neoplasms covering delicate fibrovascular stalks and are classified into two types pathologically. One type (type 1 IPNB) is histologically similar to intraductal papillary mucinous neoplasms of pancreas, and typically develops in the intrahepatic bile ducts, while the other (type 2 IPNB) has a more complex histological architecture with irregular papillary branching or with foci of solid-tubular components and typically involves the extrahepatic bile ducts. This report states the diagnostic pathologic features of IPNB proposed by WHO 2010. Since currently, the concept of IPNB is still confusing, the proposed diagnostic pathologic features stated here will be of use for future clinicopathological and molecular analyses toward consensus building of IPNB.

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“…They represent around 4% of malignant epithelial tumors of the extrahepatic bile ducts . The IPNB designation introduced by the WHO Classification in 2010 corresponds to the lesion first described by Albores‐Saavedra as “papillary carcinoma of the bile duct.” In the past, IPNB has also been referred to as papillary cholangiocarcinoma, intraductal papillary mucinous tumor, biliary papillomatosis, mucin‐producing bile duct tumors, and biliary cystadenocarcinomas with no ovarian‐like stroma …”

Section: Discussionmentioning

confidence: 99%

“…IPNB has been reported to represent the bile duct counterpart of intraductal papillary mucinous neoplasm of the pancreas (IPMN) given similar clinicopathologic features such as age and sex distribution, and papillary growth pattern with similar height of the papillae . However, IPNB shows less incidence of mucin hypersecretion, more extensive lateral spreading, more dilatation of the associated ducts, and higher incidence of invasion (50‐80% vs 38%) with respect to IPMN . According to a publication from Fukumura et al, certain IPNBs can be further classified into four subtypes similar to IPMN: gastric, intestinal, pancreatobiliary, and oncocytic.…”

Section: Discussionmentioning

confidence: 99%

Cytomorphology of intraductal papillary neoplasm of the biliary tract

Canepa

Yao

Nam

et al. 2019

Diagnostic Cytopathology

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Intraductal papillary neoplasms of the bile duct (IPNBs) are papillary epithelial proliferations with delicate fibrovascular cores within dilated bile ducts. They are thought to be premalignant lesions with potential to progress invasive tumors. To our knowledge, there are no prior descriptions of IPNB cytomorphology. A 58‐year‐old male presented with painless jaundice and elevated liver function tests was found to have an intraluminal mass within the left hepatic duct. A bile duct brushing diagnosed as “atypical cells present” showed a cellular specimen composed of papillary groups and linear strips of mostly cuboidal/columnar cells with mild atypia and vacuolated cytoplasm. A left hepatic lobectomy including extrahepatic bile ducts showed the mass consisted of papillary cores lined by pancreatobiliary‐type epithelium with mild‐to‐severe atypia, consistent with IPNB with a focus suspicious for invasion. The cytomorphologic features described in the current case suggest intraductal papillary neoplasm but may not be specific since similar features could be seen in other bile duct tumors and even in nonneoplastic conditions such as stent or cholelithiasis. However, it is worthwhile to report papillary hyperplasia with atypia in common bile duct brushings in order to avoid a false‐negative diagnosis, especially in the context of a filling defect by images which does not appear to be a stone.

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Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm

Cited by 47 publications

References 28 publications

RNF43 mutation frequently occurs with GNAS mutation and mucin hypersecretion in intraductal papillary neoplasms of the bile duct

RNF43 mutation frequently occurs with GNAS mutation and mucin hypersecretion in intraductal papillary neoplasms of the bile duct

A statement by the Japan‐Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage

Cytomorphology of intraductal papillary neoplasm of the biliary tract

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