2013
DOI: 10.1111/apha.12115
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Characterization of ion currents of murine CD117pos stem cells in vitro and their modulation under AT2R stimulation

Abstract: CD117(pos) cells do not have properties of action potential-generating cells and moderately change their excitability during AT2 R stimulation. Electrophysiological and molecular properties of control and AT2 R-stimulated cells point to a differentiation to vascular endothelial cells. This could increase beneficial vascularization in injured tissues.

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Cited by 4 publications
(9 citation statements)
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“…Therefore, the AT2R stimulation might be a relevant factor to induce changes in cell morphology as shown here for CD117 + SC. This data supports a previous study [17] indicating that AT2R stimulation could be involved in an endothelial-like differentiation of stem cells.…”
Section: At2r Stimulation Significantly Increases Cd117+ Cell Elongatsupporting
confidence: 93%
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“…Therefore, the AT2R stimulation might be a relevant factor to induce changes in cell morphology as shown here for CD117 + SC. This data supports a previous study [17] indicating that AT2R stimulation could be involved in an endothelial-like differentiation of stem cells.…”
Section: At2r Stimulation Significantly Increases Cd117+ Cell Elongatsupporting
confidence: 93%
“…Only isolations with a purity of at least 80 % were used for further experiments as previously established by us [17]. The efficiency of AT2R stimulation with Angiotensin II (while AT1R was inhibited with Losartan; (A/L stimulation)) was verified by qRT-PCR, showing an 11.38 ± 2.71-fold (n = 5) elevated AT2R mRNA expression compared to unstimulated control cells (Fig.…”
Section: Resultsmentioning
confidence: 99%
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