Characterization of lacrimal gland lesions and possible pathogenic mechanisms of keratoconjunctivitis sicca in dogs with leishmaniosis

Naranjo, Carolina; Fondevila, Dolors; Leiva, Marta; Roura, Xavier; Peña, Teresa

doi:10.1016/j.vetpar.2005.05.017

Cited by 40 publications

(73 citation statements)

References 19 publications

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“…The alterations observed in the present study in the lymphoid nodules and goblet cells of the conjunctiva have not been previously reported (MOLLEDA et al, 1993;GARCIA-ALONSO et al, 1998;DIAS, 1998;NARANJO et al, 2005). These conditions are probably the result of the intense inflammatory response observed in these structures.…”

Section: Discussionsupporting

confidence: 54%

“…Lymphoplasmacytic infiltration has been observed in various organs such as skin, spleen, liver, intestine, lung and kidneys (SILVA, 1997;TAFURI et al, 2001;XAVIER, 2002) in addition to structures of the eyeball (GARCIA- ALONSO et al, 1998;MOLLEDA et al, 2003;NARANJO et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, atrophy of the serous and mucous acini was the predominant alteration. Inflammation associated with acinar and ductal alterations has been suggested to be related to the deficit in tear production observed in canine visceral leishmaniasis (NARANJO et al, 2005). The main findings in the third eyelid gland were granulomatous or pyogranulomatous infiltrates mainly located around ducts and the marked presence of macrophages, lymphocytes and plasma cells.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological findings and detection of parasites in the eyes of dogs infected naturally with Leishmania chagasi

et al. 2010

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Histopathological findings and detection of parasites in the eyes of dogs infected naturally with Leishmania chagasi

et al. 2010

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“…This in turn would alter local antigen detection, favoring the effector lymphocyte pathway and thus triggering local inflammation (SMITH, 2005) (Figure 1 infection (due to inflammation generated by direct action of virus in the conjunctival cells), congenital acinar hypoplasia, chronic blepharoconjunctivitis (due to entropion, ectropion, trichiasis and atopy), protrusion of the third eyelid gland, traumatic proptosis (GRAHN & STOREY, 2004). NARANJO et al (2005) recently reported that dogs affected with leishmaniasis develop KCS by direct parasitism of the agent in the ductal component of the lachrymal glands and also in the Meibonian glands, by means of immunohistochemistry.…”

Section: Etiopathogenesismentioning

confidence: 99%

“…At the molecular level, pimecrolimus binds to the macrophilin-12 receptor, inhibiting calcineurin, with a consequent blockade of the production of interleukin-2 and of type 1 and 2 helper T cells (NELL et al, 2005).…”

Section: Pimecrolimusmentioning

confidence: 99%

Qualitative and quantitative tear film abnormalities in dogs

et al. 2008

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Study of ocular manifestations and humoral immune response in eyes of dogs with leishmaniasis

Goulli

Zribi

Sanhaji

et al. 2022

Veterinary Medicine & Sci

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Background Ocular manifestations in dogs with leishmaniasis are frequent and complications in affected tissues can lead to blindness. Immune processes play a very important role in the pathogenesis of ocular inflammation. Therefore, the immunology of ocular manifestations in dogs with leishmaniasis remains complex and poorly understood. Objectives Estimation and characterisation of ocular and periocular manifestations in dogs naturally infected with Leishmania infantum and investigation of the production site of specific anti‐Leishmania infantum IgG. Methods The present investigation used 53 confirmed dogs infected with Leishmania infantum, presenting ocular and periocular lesions, and 10 control non‐infected dogs. Complete macroscopic ophthalmic examination of eyelids and globes was performed. Both total and anti‐Leishmania infantum IgG antibodies were studied in sera and aqueous humour (AH) of all dogs by ELISA technique. A Goldmann–Witmer coefficient (C value) was calculated. Results The main ophthalmological findings were keratoconjunctivitis (71.7%; 38/53), hyperplasia of conjunctival lymphoid follicles (54.7%; 29/53), blepharitis (50.9%; 27/53) and uveitis (20.7%; 11/53). Ocular production of anti‐Leishmania infantum IgG was detected in 73.6% (39/53) of infected dogs. There was no correlation between the antibody levels in AH and sera of the same dog. The mean anti‐Leishmania infantum IgG in AH was higher in uveitis, followed by lesions affecting only the adnexa (p < 0.0001). The highest mean C values were observed for uveitis, conjunctivitis and keratitis. Conclusions Our findings suggest that production of anti‐Leishmania IgG in dogs infected with Leishmania infantum with ocular manifestations begin in situ and follows by a transfer of antibodies from the bloodstream to the AH.

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Characterization of lacrimal gland lesions and possible pathogenic mechanisms of keratoconjunctivitis sicca in dogs with leishmaniosis

Cited by 40 publications

References 19 publications

Histopathological findings and detection of parasites in the eyes of dogs infected naturally with Leishmania chagasi

Histopathological findings and detection of parasites in the eyes of dogs infected naturally with Leishmania chagasi

Qualitative and quantitative tear film abnormalities in dogs

Study of ocular manifestations and humoral immune response in eyes of dogs with leishmaniasis

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