Characterization of Leishmania isolated in Iran: 1. Serotyping with species specific monoclonal antibodies

Comparative study of the efficacy of oral ketoconazole with intra-lesional meglumine antimoniate (Glucantime) for the treatment of cutaneous leishmaniasis

“…The causative species of CL in our area have been studied and identi ed as L. tropica and L. major. 12 The results of our study showed a very good response to oral ketoconazole with minimal side effects, none necessitating discontinuation of the medication. Although our results differ from those of Ozgoztasi and Baydar, 11 the difference may be due to the dosage used by those investigators (400 mg/day), which appears to be too little to achieve optimal therapeutic serum levels.…”

Atypical presentation of Old‐World cutaneous leishmaniasis, diagnosis and species identification by PCR

“…Fars province, Southern Iran is a hyperendemic region of CL. In this region, both L. major and L. tropica had been identified as the causative agents of CL 3 . Direct microscopic identification of Leishmania amastigotes in smears or tissue samples, commonly used for CL diagnosis, is rapid and easy to use.…”

PCR detection and sequencing of parasite ITS-rDNA gene from reservoirs host of zoonotic cutaneous leishmaniasis in central Iran

“…In recent surveys, some isolates from patients living in rural villages near the burrows of the great gerbil R. opimus were identified as L. major after typing with isoenzymes (Ardehali et al 1994), monoclonal antibodies (Ardehali et al 2000), the sizing of fragments of minicircle kinetoplast DNA amplified by PCR (Mahboudi et al 2001;Azizi et al 2006), and by singlestrand conformation polymorphism and sequence analyses of ITS-rDNA (Tashakori et al 2006). Out of 120 patients from different parts of Iran (Mahboudi et al 2001), 103 were living in rural areas, and 100 had L. major infections (29 with the Nadim strain and 71 with the P strain).…”

“…Isfahan is the one of the known focus of ZCL in Iran in which Rhombomis opimus is main reservoir, and Meriones lybicus is secondary principal reservoir host of ZCL in these areas (Nadim and Faghih 1968;Yaghoobi-Ershadi et al 1996). The causative organisms of human cutaneous leishmaniasis in Iran have been characterized on the basis of clinical symptoms (Momeni Brojeni 1994;Dowlati and Firooz 1997), geographical focality or specific reservoir hosts (Nadim and Faghih 1968;Nadim and Seyedi-Rashti 1971), infection of experimental animals and vectors (Nadim et al 1968a, b;Nadim and Seyedi-Rashti 1971;Nasseri and Modabber 1977;Javadian and Seyedi-Rasti 1991;Yaghoobi-Ershadi et al 1995a, b), and serology (Edrissian 1996), sometimes with species-specific monoclonal antibodies (Ardehali et al 2000).…”