Low cycle fatigue (LCF) and creep fatigue interaction (CFI) behaviour of P92 steel welded joint were investigated experimentally and numerically. Strain‐controlled LCF tests at different strain amplitudes and CFI tests at different peak strain holding time were conducted. Evolutions of cyclic stress response, mean stress, and creep strain during cycling were described, in which the influence of strain amplitude and holding time were investigated. A specific heat treatment process was proposed to get the homogenous simulated material of fine grain region and coarse grain region in the heat affected zone. Material parameters of parent material, fine grain heat affected zone, coarse grain heat affected zone, and weld metal in the unified viscoplasticity model were then determined and validated. To predict the LCF and CFI behaviour of welded joint, 3‐dimensional unified viscoplasticity model with a modified isotropic variable was compiled into ABAQUS UMAT. The comparison between the predicted and experimental result under LCF and CFI loadings showed that the simulation results were reasonable and agreed with the experimental data well.