Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

Li, Yuanyuan; Han, Ye; Wang, Ting; Wang, Peng; Li, Yinping; Tian, Yingying; Zhang, Jingliang

doi:10.3390/md18100499

Cited by 30 publications

(15 citation statements)

References 44 publications

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“…In the meantime, ulvan is able to recover abnormal levels of oxidative stress and cytokines, and helps to boost the anti-inflammation, as well as anti-oxidation. Li [ 42 ] revealed that ulvan has an alleviative effect on inflammatory bowel disease (IBD) by reducing the DSS-induced disease activity index, colon shortening, and colonic tissue damage. We still need to conduct some targeted bioactive studies using modern technology in order to explore and promote the potential industrial applications of ulvan.…”

Section: Ulvanmentioning

confidence: 99%

Insights into the Edible and Biodegradable Ulvan-Based Films and Coatings for Food Packaging

Wang

Cao

Yao

et al. 2023

Foods

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Recently, edible films or coatings that are made from algal polysaccharides have become promising candidates for replacing plastic-based packaging materials for food storage due to their non-toxic, biodegradable, biocompatible, and bioactive characteristics. Ulvan, a significant biopolymer with unique functional properties derived from marine green algae, has been extensively used in various sectors. However, there are fewer commercial applications of this sugar in the food packaging industry compared to many other algae-derived polysaccharides, such as alginates, carrageenan, and agar. This article aims to review the unparalleled chemical composition/structure and physiochemical properties of ulvan and the latest developments in ulvan-based edible films and coatings, thus highlighting their potential applications in the food packaging industry.

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Section: Ulvanmentioning

confidence: 99%

Insights into the Edible and Biodegradable Ulvan-Based Films and Coatings for Food Packaging

Wang

Cao

Yao

et al. 2023

Foods

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“…These heterodisperse sulfated polymers are quite diverse, but generally contain rhamnose, xylose, galactose, and uronic acid. They exhibit lipid-lowering activity [ 13 ], protective effects in irritable bowel syndrome (IBD) models [ 19 ], and antioxidant and antihyperlipidemic effects [ 20 , 21 , 22 ]. A hyperlipidemic rat model showed reductions in non-HDL-cholesterol and increases in HDL-cholesterol and a corresponding improvement in the atherogenic index (log (triglycerides/HDL-cholesterol)) [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Improved Plasma Lipids, Anti-Inflammatory Activity, and Microbiome Shifts in Overweight Participants: Two Clinical Studies on Oral Supplementation with Algal Sulfated Polysaccharide

Roach

Meyer

Fitton³

et al. 2022

Marine Drugs

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Seaweed polysaccharides in the diet may influence both inflammation and the gut microbiome. Here we describe two clinical studies with an Ulva sp. 84-derived sulfated polysaccharide—“xylorhamnoglucuronan” (SXRG84)—on metabolic markers, inflammation, and gut flora composition. The first study was a double-blind, randomized placebo-controlled trial with placebo, and either 2 g/day or 4 g/day of SXRG84 daily for six weeks in 64 overweight or obese participants (median age 55 years, median body mass index (BMI) 29 kg/m2). The second study was a randomized double-blind placebo-controlled crossover trial with 64 participants (median BMI 29 kg/m2, average age 52) on placebo for six weeks and then 2 g/day of SXRG84 treatment for six weeks, or vice versa. In Study 1, the 2 g/day dose exhibited a significant reduction in non-HDL (high-density lipoprotein) cholesterol (−10% or −0.37 mmol/L, p = 0.02) and in the atherogenic index (−50%, p = 0.05), and two-hour insulin (−12% or −4.83 mU/L) showed trends for reduction in overweight participants. CRP (C-reactive protein) was significantly reduced (−27% or −0.78 mg/L, p = 0.03) with the 4 g/day dose in overweight participants. Significant gut flora shifts included increases in Bifidobacteria, Akkermansia, Pseudobutyrivibrio, and Clostridium and a decrease in Bilophila. In Study 2, no significant differences in lipid measures were observed, but inflammatory cytokines were improved. At twelve weeks after the SXRG84 treatment, plasma cytokine concentrations were significantly lower than at six weeks post placebo for IFN-γ (3.4 vs. 7.3 pg/mL), IL-1β (16.2 vs. 23.2 pg/mL), TNF-α (9.3 vs. 12.6 pg/mL), and IL-10 (1.6 vs. 2.1 pg/mL) (p < 0.05). Gut microbiota abundance and composition did not significantly differ between groups (p > 0.05). Together, the studies illustrate improvements in plasma lipids and an anti-inflammatory effect of dietary SXRG84 that is participant specific.

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“…Thanks to its biological properties, such as antihyperlipidemic and immunomodulatory, and especially its powerful antioxidant activity, Ulva pertusa is widely used in traditional Chinese medicine as a medication for many human diseases [ 8 ], thus representing a promising natural compound for functional food and drug development [ 9 ]. Despite previous reports [ 10 , 11 ] that have highlighted the activity of Ulva extracts in providing intestinal relief, the knowledge of the multiple molecular pathways with which it acts is still poor.…”

Section: Introductionmentioning

confidence: 99%

Ulva pertusa, a Marine Green Alga, Attenuates DNBS-Induced Colitis Damage via NF-κB/Nrf2/SIRT1 Signaling Pathways

Ardizzone

Filippone

Mannino

et al. 2022

JCM

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Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) represent gastrointestinal (GI) disorders associated with varied responses to microbial and environmental agents. Natural compounds have been suggested as a valid approach to the management of various GI diseases, particularly the green alga Ulva pertusa, belonging to the Ulvaceae family, which showed powerful biological properties. Here, we aimed to evaluate the effect and the mechanism of Ulva pertusa treatments in a murine model of DNBS-induced colitis. Colitis was induced by DNBS intrarectal installation (4 mg in 100 μL of 50% ethanol), while Ulva pertusa treatments (doses of 10, 50 and 100 mg/kg) were administered orally daily. Ulva pertusa, at the higher doses of 50 and 100 mg/kg, significantly reduced tissue damage DNBS-induced and the consequent inflammatory cascade via NF-κB inhibition. Furthermore, we demonstrated, for the first time, Ulva pertusa action on the SIRT1/Nrf2 axis, enhancing antioxidant response and the modulation of the apoptosis pathway colitis-induced, regulating the expression of p53, Bax, Bcl-2, and Caspases. Taken together, Ulva pertusa could be considered a valid approach for counteracting and blocking the progression of IBDs through modulation of the NF-κB/SIRT1/Nrf2 axis.

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Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

Abstract: Inflammatory bowel disease (IBD) has been gradually considered a public health challenge worldwide. Sulfated polysaccharides, extracted from seaweed, have been shown to have an anti-inflammatory effect on the disease[...]

Cited by 30 publications

References 44 publications

Insights into the Edible and Biodegradable Ulvan-Based Films and Coatings for Food Packaging

Insights into the Edible and Biodegradable Ulvan-Based Films and Coatings for Food Packaging

Improved Plasma Lipids, Anti-Inflammatory Activity, and Microbiome Shifts in Overweight Participants: Two Clinical Studies on Oral Supplementation with Algal Sulfated Polysaccharide

Ulva pertusa, a Marine Green Alga, Attenuates DNBS-Induced Colitis Damage via NF-κB/Nrf2/SIRT1 Signaling Pathways

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