Characterization of Macrophages and Occurrence of T cells in Intestinal Lesions of Subclinical Paratuberculosis in Goats

Valheim, Mette; Sigurðardóttir, Ólöf; Storset, Anne K.; Aune, L; Press, Charles McL.

doi:10.1016/j.jcpa.2004.04.004

Cited by 28 publications

(25 citation statements)

References 46 publications

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“…paratuberculosis with ileal tissue in cattle and goats, using segmented ileal loop and everted ileum models, has shown that M. avium subsp. paratuberculosis is rapidly taken up within minutes by microfold cells, enterocytes, macrophages, and most likely dendritic cells (19,28,(37)(38)(39)44). Examination of mesenteric lymph nodes and other peripheral tissue following direct inoculation into the ileum, using a surgical intervention model, revealed that M. avium subsp.…”

Section: Discussionmentioning

confidence: 99%

Development of a Bovine Ileal Cannulation Model To Study the Immune Response and Mechanisms of Pathogenesis of Paratuberculosis

Allen

Park

Barrington

et al. 2009

Clin Vaccine Immunol

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Section: Discussionmentioning

confidence: 99%

Development of a Bovine Ileal Cannulation Model To Study the Immune Response and Mechanisms of Pathogenesis of Paratuberculosis

Allen

Park

Barrington

et al. 2009

Clin Vaccine Immunol

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“…paratuberculosisinfected macrophages of the ileum. Previous reports have clarified the expression status of MHC-II in Johne's disease (21,22), and MHC class II molecules were reportedly expressed in the small intestinal mucosa of a goat with subclinical infection (21) and in CD11c ϩ dendritic cells from M. avium subsp. paratuberculosis-induced cattle granulomas (22).…”

Section: Paratuberculosis-infected Groupmentioning

confidence: 99%

Bovine Immunoinhibitory Receptors Contribute to Suppression of Mycobacterium avium subsp. paratuberculosis-Specific T-Cell Responses

et al. 2016

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“…Esses achados reforçam o envolvimento da reação de hipersensibilidade tardia na patogênese da doença. O número reduzido de células marcadas por Ki-67 indica que a proliferação celular não foi o principal responsável pela hipercelularidade observada nas lesões granulomatosas por consumo de V. villosa, e que o recrutamento de macrófagos e linfócitos para o local da inflamação deve ter sido o responsável pelo acúmulo inflamatório (Valheim et al 2004). …”

Section: Discussão E Conclusõesunclassified

Achados patológicos e imuno-histoquímicos em bovinos com doença granulomatosa sistêmica pelo consumo de Vicia villosa (Leg. Papilionoideae) no Rio Grande do Sul

et al. 2011

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Pesq. Vet. Bras. 31(4): 307-312, abril 2011 RESUMO.-A doença granulomatosa sistêmica associada ao consumo de Vicia villosa (Leg. Papilionoideae) foi diagnosticada em 5 bovinos no período de 2005 a 2008. Os bovinos apresentavam alopecia, lesões crostosas na pele, prurido, febre, queda da produção leiteira, anorexia e emagrecimento. O curso clínico médio da doença foi de 2 semanas. Dos bovinos analisados três morreram e dois foram eutanasiados. As lesões macroscópicas de alopecia e crostas na pele eram localizadas principalmente na face e pescoço. Observava-se nódulos multifocais a coalescentes branco-acinzentados que infiltravam vários órgãos especialmente em linfonodos, rins e coração. As lesões microscópicas consistiam na infiltração de linfócitos, macrófagos, células epitelioides, células gigantes multinucleadas, eosinófilos e plasmócitos. Linfonodos, rins, adrenal, baço e fí-gado de todos os bovinos apresentaram infiltrado granulo- Affected cattle showed alopecia, crusted lesions on the skin, had itching, fever, decreased milk yield, anorexia and wasting. Average clinical course was 2 weeks. Three cattle died and two were euthanized in extremis. The main gross changes are alopecic and crusts in the skin, mainly on the face and neck. There also were multifocal to coalescent whitish nodules that infiltrated several organs, but especially lymph nodes, kidneys and hearth. Microscopic changes consisted of infiltration with lymphocytes, macrophages, epithelioid cells, giant multinucleated cells, eosinophils, and plasmocytes. Lymph nodes, kidneys, adrenal gland, spleen and liver from affected cattle showed varying degrees of granulomatous infiltration. Immunohistochemical procedures on samples from affected organs revealed that Tlymphocytes and macrophages/epithelioid cells/giant multinucleated cells were the main components of the inflammatory infiltrates, B-lymphocytes were only rarely seen within. The reduced numbers of cells marked by Ki-67 in the granulomatous lesions would indicate that cell proliferation was not responsible for the hypercellularity in the lesions and that rather the recruitment of macrophages and lymphocytes to the site inflammation probably accounted for the building up of the local cellular inflammatory infiltrate.

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Characterization of Macrophages and Occurrence of T cells in Intestinal Lesions of Subclinical Paratuberculosis in Goats

Cited by 28 publications

References 46 publications

Development of a Bovine Ileal Cannulation Model To Study the Immune Response and Mechanisms of Pathogenesis of Paratuberculosis

Development of a Bovine Ileal Cannulation Model To Study the Immune Response and Mechanisms of Pathogenesis of Paratuberculosis

Bovine Immunoinhibitory Receptors Contribute to Suppression of Mycobacterium avium subsp. paratuberculosis-Specific T-Cell Responses

Achados patológicos e imuno-histoquímicos em bovinos com doença granulomatosa sistêmica pelo consumo de Vicia villosa (Leg. Papilionoideae) no Rio Grande do Sul

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