Characterization of malignant thyroid gland tissue by magnetic resonance methods

Schara, M.; Šentjurc, Marjeta; Auersperg, M.; Golouh, Rastko

doi:10.1038/bjc.1974.101

Cited by 23 publications

(3 citation statements)

References 6 publications

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“…1986), fibrosis (Farmer et al 1984) and local inflammation with host cell infiltration (Ling and Foster 1982) . Tumour hypoxia per se probably does not modify the values of proton Tl and T2 significantly (Schara et al 1974, Belfi et al 1991) . However, necrotic tissue can be distinguished from viable tissue in 'H-nmr images of tumours (Ngo et al 1985, Dodd et al .…”

mentioning

confidence: 99%

Magnetic Resonance Imaging of Human Melanoma Xenograftsin Vivo: Proton Spin—lattice and Spin—spin Relaxation Times Versus Fractional Tumour Water Content and Fraction of Necrotic Tumour Tissue

Rofstad

Steinsland

Kaalhus

et al. 1994

International Journal of Radiation Biology

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Proton nuclear magnetic resonance (1H-nmr) imaging is used routinely in clinical oncology to provide macroscopic anatomical information, whereas its potential to provide physiological information about tumours is not well explored. To evaluate the potential usefulness of 1H-nmr imaging in the prediction of tumour treatment resistance caused by unfavourable microenvironmental conditions, possible correlations between proton spin-lattice and spin-spin relaxation times (T1 and T2) and physiological parameters of the tumour microenvironment were investigated. Tumours from six human melanoma xenograft lines were included in the study. 1H-nmr imaging was performed at 1.5 T using spin-echo pulse sequences. T1- and T2-distributions were generated from the images. Fractional tumour water content and the fraction of necrotic tumour tissue were measured immediately after 1H-nmr imaging. Significant correlations across tumour lines were found for T1 and T2 versus fractional tumour water content (p < 0.001) as well as for T1 and T2 versus fraction of necrotic tumour tissue (p < 0.05). Tumours with high fractional water contents had high values of T1 and T2, probably caused by free water in the tumour interstitium. Fractional water content is correlated to interstitial fluid pressure in tumours, high interstitial fluid pressure being indicative of high vascular resistance. Tumours with high fractional water contents are thus expected to show regions with radiobiologically hypoxic cells as well as poor intravascular and interstitial transport of many therapeutic agents. T1 and T2 decreased with increasing fraction of necrotic tumour tissue, perhaps because complexed paramagnetic ions were released during development of necrosis. Viable tumour cells adjacent to necrotic regions are usually chronically hypoxic. Tumours with high fractions of necrotic tissue are thus expected to contain significant proportions of radiobiologically hypoxic cells. Consequently, quantitative 1H-nmr imaging has the potential to be developed as an efficient clinical tool in prediction of tumour treatment resistance caused by hypoxia and/or transport barriers for therapeutic agents. However, much work remains to be done before this potential can be adequately evaluated. One problem is that high fractional tumour water contents result in longer T1 and T2 whereas high fractions of necrotic tumour tissue result in shorter T1 and T2; i.e. the two parameters which are indicative of treatment resistance contribute in opposite directions. Another problem is that the correlations for T1 and T2 versus fraction of necrotic tumour tissue are not particularly strong.

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mentioning

confidence: 99%

Magnetic Resonance Imaging of Human Melanoma Xenograftsin Vivo: Proton Spin—lattice and Spin—spin Relaxation Times Versus Fractional Tumour Water Content and Fraction of Necrotic Tumour Tissue

Rofstad

Steinsland

Kaalhus

et al. 1994

International Journal of Radiation Biology

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“…However, a number of confounding factors, including histologic inhomogeneity of the lesion as well as areas of necrosis (7,10,12), haemorrhage and fibrosis (7), would affect relaxation times independently of possible true changes related to malignant growth. In animal studies performed by OSBAKKEN et coll.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Tissue Characterization by Proton Magnetic Resonance Relaxation Time Determination

Tennvall¹,

Olsson²,

Möller³

et al. 1987

Acta Oncologica

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“…Nuclear magnetic resonance was referenced in articles as far back as 1966 (9), the earliest year included in our search. The first citation listing a clinical application for MRI in humans was found in 1974 (11). Through December 1986, MRI was mentioned in over 12,000 journal articles covering all areas of medicine and was the major subject in 1,689 citations.…”

Section: Magnetic Resonance and The Medical Literaturementioning

confidence: 99%

How Important is the Scientific Literature in Guiding Clinical Decisions?: The Case of Magnetic Resonance Imaging

Ramsey

Hillman

Renshaw

et al. 1993

Int J Technol Assess Health Care

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Little is known about how information diffuses to clinicians and influences their purchase and use of new technology. This is especially true about the role of the scientific literature. As a case study, we examined the literature for magnetic resonance imaging (MRI) during the years preceding and the first five years following its clinical introduction. Using a computerized retrieval system, we identified approximately 1,700 citations in which MRI was the major topic. The clinical literature on MRI was heavily concentrated in radiology journals. Less than 28% of articles compared MRI with alternative diagnostic technologies. During the first five years of clinical availability, the diffusion patterns of scientific articles and operational units mirrored the example set by computerized tomography (CT), in that a substantial number of units were purchased in both research and nonresearch settings before studies were available comparing them to alternative diagnostic technologies. These patterns of diffusion, combined with other studies of the MRI literature's content and methodology, suggest that less comprehensive and objective sources of information were important in early purchasing decisions. This study also suggests that the present readership and publication patterns of professional journals may not facilitate effective, rapid information dissemination about innovations to a broad spectrum of clinicians.

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Characterization of malignant thyroid gland tissue by magnetic resonance methods

Cited by 23 publications

References 6 publications

Magnetic Resonance Imaging of Human Melanoma Xenograftsin Vivo: Proton Spin—lattice and Spin—spin Relaxation Times Versus Fractional Tumour Water Content and Fraction of Necrotic Tumour Tissue

Magnetic Resonance Imaging of Human Melanoma Xenograftsin Vivo: Proton Spin—lattice and Spin—spin Relaxation Times Versus Fractional Tumour Water Content and Fraction of Necrotic Tumour Tissue

Thyroid Tissue Characterization by Proton Magnetic Resonance Relaxation Time Determination

How Important is the Scientific Literature in Guiding Clinical Decisions?: The Case of Magnetic Resonance Imaging

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