Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84

Krause, Stefan W.; Rehli, Michael; Heinz, Sven; Andreesen, Reinhard

doi:10.1042/bj3460729

Cited by 16 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD84 was expressed on all splenic B cells and monocytes (Fig. 1), in agreement with previous results obtained for B cell and myeloid cell lines 23, 24. CD84 was also detected on CD4 + and CD8 + T cells, but not NK cells (Fig.…”

Section: Resultssupporting

confidence: 91%

CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2

et al. 2002

View full text Add to dashboard Cite

CD84 is a member of the CD2 subset of the immunoglobulin superfamily of cell surface receptors. Several members of this family are involved in the activation of T cells and NK cells. Although CD84 was originally cloned from a human B cell line cDNA library, very little is known regarding its biology on primary human leukocytes. We investigated the expression and biochemistry of CD84 on human B cells. CD84 was expressed on B cells in peripheral blood, spleen and cord blood. Two populations of splenic B cells could be resolved, CD84lo and CD84hi. CD84hi B cells represented a subset of memory B cells as demonstrated by increased cell size, co‐expression of the memory B cell‐specific marker CD27, somatically mutated Ig variable region genes, and increased proliferation compared to CD84lo B cells. CD84 became rapidly phosphorylated on tyrosine residues following ligation with a specific monoclonal antibody and recruited the cytoplasmic adaptor proteins SAP and EAT‐2. The ability of CD84 to undergo tyrosine phosphorylation and to recruit these SH2 domain‐containing proteins suggests it may function in the activation of B cells, particularly memory cells, and its signal transduction pathway may utilize SAP and/or EAT‐2. Thus, investigation of expression and function of CD84 and CD27 is likely to contribute to a greater understanding of the development and biology of memory B cells in normal and immunocompromised hosts.

show abstract

Section: Resultssupporting

confidence: 91%

CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2

et al. 2002

View full text Add to dashboard Cite

show abstract

“…CD84 is expressed on double negative-and single positive (CD4 + or CD8 + )-thymocytes, T cells, B cells, dendritic cells (DCs), monocytes, macrophages, platelets, granulocytes, mast cells, eosinophils, and basophils [26][27][28][29][30]. However, it is absent from double positivethymocytes and human NK cells [30], although not from murine NK cells [31].…”

Section: Discussionmentioning

confidence: 99%

Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: From pro-B to plasma cells

et al. 2011

View full text Add to dashboard Cite

“…CD84 is expressed on thymocytes, T-, B-lymphocytes, platelets, DCs, and monocytes (20,34,35). CD84 expression was highly regulated at specific stages of differentiation and maturation of B and T cells.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of SAP and EAT‐2‐binding leukocyte cell‐surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)

et al. 2004

View full text Add to dashboard Cite

The CD150 (SLAM) family consists of nine leukocyte cell-surface proteins involved in lymphocyte activation that belong to the immunoglobulin (Ig) superfamily. Six members of this family--CD84, CD150 (SLAM), CD229 (Ly9), CD244 (2B4), NTB-A, and CS1--associate with adapter proteins--SLAM-associated protein (SAP) and EAT-2. SAP is a short intracellular molecule that is mutated in humans with X-linked lymphoproliferative disease. Flow cytometric analysis of the expression of CD84, CD150, CD229, and CD244 cell-surface receptors on several leukocyte and lymphocyte subsets was performed. CD84 and CD150 were present on thymocytes, mature T cells and antigen-presenting cells. The expression of CD84 and CD150 was high on memory T cells. CD150 expression was strongly up-regulated after cell activation. In contrast to CD84, CD150 was absent on resting monocytes and immature dendritic cells (DCs). CD229 presented a pattern of expression restricted to lymphocytes. CD244 was preferentially expressed on natural killer cells, CD8(+) effector cells, resting monocytes, basophils, and eosinophils. We describe a broader distribution of CD84, CD150, CD229, and CD244 than previously reported and show that they are differentially expressed on hematopoietic cells. The heterogeneous expression of these receptors indicates that these molecules may play non-redundant functions in the regulation of both innate and adaptive immune responses.

show abstract

Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84

Cited by 16 publications

References 37 publications

CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2

CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2

Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: From pro-B to plasma cells

Differential expression of SAP and EAT‐2‐binding leukocyte cell‐surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)

Contact Info

Product

Resources

About