Characterization of Membrane of Poly (L,co-D,L-lactic acid-co-trimethylene carbonate) (PLDLA-co-TMC) (50/50) loaded with Silk Fibroin

Abstract

Silk produced by Bombyx-mori consists of two proteins sericin and fibroin. Silk Fibroin (SF) an attractive material for epithelial tissue regeneration. The aim of this study was to characterize membranes of PLDLAco-TMC:SF (2:1 w/w) once it could be used as a wound dressing to burn treatment and epithelial tissue regeneration. Membranes of Poly(L-co-D,L-lactic acid-co-TMC) with SF were prepared by casting method and it was analysed by: FTIR -there was no change in the PLDLA-co-TMC spectrum after SF has been added in polymers' solution, Swelling Test -the samples with SF had a different swelling behaviour of PLDLA-co-TMC. Membrane with SF showed swelling rate faster than PLDLA-co-TMC. Contact angle measurement -PLDLAco-TMC (1:1 w/w) showed a contact angle value higher than samples with SF. SEM -the addition of SF in PLDLA-co-TMC apparently leaves the polymer surface more roughened. Tensile test -there was a decrease in the Young's modulus and there was an increase in the elongation at break of PLDLA-co-TMC:SF membrane, DSC -SF did not change the glass temperature (Tg) of PLDLAco-TMC. The membrane of PLDLA-co-TMC:SF was characterized and it has potential to be used as a wound dressing to burn treatment and epithelial tissue regeneration.