Characterization of methicillin‐resistant <i>Staphylococcus aureus</i> strains colonizing the nostrils of Spanish children

Román, Federico; Méndez-Echevarría, Ana; Rosal, Teresa Del; Vera, César García; Escosa-García, Luis; Agud, Martin; Cháves, Fernando; Gutiérrez‐Fernández, José; Gopegui, Enrique Ruíz de; Ruiz‐Carrascoso, Guillermo; Ruiz‐Gallego, Maria del Carmen; Bernet, Albert; Quevedo, Sara Maria; Fernández-Verdugo, Ana; Sainz, Talía; Calvo, Cristina

doi:10.1002/mbo3.1235

Cited by 2 publications

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“…Nasal swabs to detect S. aureus and MRSA colonisation were collected during the first 48 h after hospital admission and analysed following the standardized protocol of the COSACO study 9 , 25 . Each sample was collected by inserting the swab tip into the two nostrils and rotating it for 5 s on each side, using ESwab™ flocked swabs with Liquid Amies Medium (Copan, Brescia, Italy) 9 .…”

Section: Methodsmentioning

confidence: 99%

“…Each sample was collected by inserting the swab tip into the two nostrils and rotating it for 5 s on each side, using ESwab™ flocked swabs with Liquid Amies Medium (Copan, Brescia, Italy) 9 . Methicillin resistance was detected by the disk diffusion method with cefoxitin (30 µg), as well as by susceptibility testing and disk diffusion to other antibiotics 25 . Minimum inhibitory concentrations for MRSA strains were studied with E-test ® strips (bioMérieux).…”

Section: Methodsmentioning

confidence: 99%

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Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions

Agud

Medrano

Méndez-Echevarría

et al. 2022

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To assess drug-resistant bacterial colonisation rates and associated risk factors in children with complex chronic conditions admitted to a national reference unit in Spain. Cross-sectional study that included all children admitted to our unit from September 2018 to July 2019. Rectal swabs were obtained to determine multidrug-resistant Gram-negative bacilli (MR-GNB) colonisation, and nasal swab to determine S. aureus and methicillin-resistant S. aureus (MRSA) colonisation. Medical records were reviewed. 100 children were included, with a median of four complex chronic conditions. Sixteen percent had S. aureus colonisation, including two MRSA. S. aureus colonisation was associated with technology-dependent children, while being on antibiotic prophylaxis or having undergone antibiotic therapy in the previous month were protective factors. The prevalence of MR-GNB colonisation was 27%, which was associated with immunosuppressive therapy (aOR 31; 2.02–47]; p = 0.01), antibiotic prophylaxis (aOR 4.56; 1.4–14.86; p = 0.012), previously treated skin-infections (aOR 2.9; 1.07–8.14; p = 0.03), surgery in the previous year (aOR 1.4; 1.06–1.8; p = 0.014), and hospital admission in the previous year (aOR 1.79; [1.26–2.56]; p = 0.001). The rate of S. aureus nasal colonisation in this series was not high despite the presence of chronic conditions, and few cases corresponded to MRSA. Antibiotic prophylaxis, immunosuppressive therapies, history of infections, previous surgeries, and length of admission in the previous year were risk factors for MR-GNB colonisation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions

Agud

Medrano

Méndez-Echevarría

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

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Acute bacterial skin and skin structure infections in pediatric patients: potential role of dalbavancin

Volpicelli

Venditti

Oliva

2023

Expert Review of Anti-infective Therapy

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Characterization of methicillin‐resistant Staphylococcus aureus strains colonizing the nostrils of Spanish children

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 2 publications

References 32 publications

Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions

Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions

Acute bacterial skin and skin structure infections in pediatric patients: potential role of dalbavancin

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