Characterization of microparticles of iron oxide for magnetic resonance imaging

Fouquet, Jérémie P.; Sikpa, Dina; Lebel, Réjean; Sibgatulin, Renat; Krämer, Martin; Herrmann, Katharina; Deistung, Andreas; Tremblay, Luc; Reichenbach, Jürgen R.; Lepage, Martin

doi:10.1016/j.mri.2022.05.020

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Optimized Digital Assay Based On Microfluidic Device1

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2024

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“…9 It must be noted that at the concentration corresponding to the LOD, there is a relatively high surplus of PSA molecules over MBs. Considering the binding capacity, size, and weight of a single MB, 43,44 each MB can bind approximately 6.0 × 10 4 to 7.8 × 10 4 antibody molecules. Therefore, with 50 μg mL −1 of MBs and a PSA concentration of 1.04 pg mL −1 , there are approximately 400 PSA molecules per MB, which corresponds to a fractional antibody occupancy of 0.5-0.7%.…”

Section: Optimized Digital Assay Based On Microfluidic Devicementioning

confidence: 99%