Integrating biotechnologies for the management of the circular economy in tourism contexts presents both challenges and opportunities within a circular economy framework. This study aims to examine specialized literature from the past decade to identify best practices, challenges, and opportunities for the sustainability of tourist destinations in terms of circular economy management treatment. Utilizing the PRISMA methodology for systematic reviews, the research synthesizes how biotechnological innovations can enhance waste management processes, reduce negative environmental impacts, and strengthen environmental competitiveness in tourism. The review highlights successful implementation strategies while also identifying persistent barriers that may affect the adoption of circular management for public policies. It explores potential scenarios and emerging opportunities in this field. The findings are expected to serve as a reference for decision-makers, environmental policymakers, researchers, and professionals seeking sustainable development through biotechnological innovations in the tourism sector.