Characterization of MRI techniques to assess neonatal brain oxygenation and blood flow

Liu, Peiying; Parkinson, Charlamaine; Jiang, Dengrong; Ouyang, Minhui; Vis, Jill B. De; Northington, Frances J.; Tekes, Aylin; Huang, Hao; Huisman, Thierry A.G.M.; Golden, William

doi:10.1002/nbm.4103

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Neonatal cerebral MRI is challenging due to the small brain size and high susceptibility to motion. 15 Two noninvasive MRI techniques had been used in the included studies to estimate CBF without the application of contrast agents: phase contrast (PC) in eight studies and arterial spin labeling (ASL) sequences in six studies; one study combined both methods.…”

Section: Resultsmentioning

confidence: 99%

Postnatal cerebral hemodynamics in infants with severe congenital heart disease: a scoping review

et al. 2023

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Patients with severe congenital heart disease (CHD) are at risk for impaired neurodevelopment. Cerebral blood supply may be diminished by congenital anomalies of cardiovascular anatomy and myocardial function. The aim of this scoping review was to summarize the current knowledge on cerebral hemodynamics in infants with severe CHD. A scoping review was performed. Five databases were searched for articles published from 01/1990 to 02/2022 containing information on cerebral hemodynamics assessed by neuroimaging methods in patients with severe CHD within their first year of life. A total of 1488 publications were identified, of which 26 were included. Half of the studies used Doppler ultrasound, and half used magnetic resonance imaging techniques. Studies focused on preoperative findings of cerebral hemodynamics, effects of surgical and conservative interventions, as well as on associations between cerebral hemodynamics and brain morphology or neurodevelopment. Cerebral perfusion was most severely affected in patients with single ventricle and other cyanotic disease. Neuroimaging methods provide a large variety of information on cerebral hemodynamics. Nevertheless, small and heterogeneous cohorts complicate this field of research. Further studies are needed to improve our understanding of the link between CHD and altered cerebral hemodynamics to optimize neuroprotection strategies. Impact Postnatal cerebral hemodynamics are altered in infants with congenital heart disease (CHD) as compared to healthy controls, especially in most severe types such as single ventricle or other cyanotic CHD. Associations of these alterations with brain volume and maturation reveal their clinical relevance. Research in this area is limited due to the rarity and heterogeneity of diagnoses. Furthermore, longitudinal studies have rarely been conducted. Further effort is needed to better understand the deviation from physiological cerebral perfusion and its consequences in patients with CHD to optimize neuroprotection strategies.

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Section: Resultsmentioning

confidence: 99%

Postnatal cerebral hemodynamics in infants with severe congenital heart disease: a scoping review

et al. 2023

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“…200 Note that oxygen is delivered to the fetus from the placenta through the umbilical vein, which was reported to have an average oxygenation of 84%. 202 For newborn infants, several MRI techniques have been adapted to measure OEF in the neonatal brain, including T 2 -based 57,62,[203][204][205] and phase-based 206…”

Section: Oef Across the Human Lifespanmentioning

confidence: 99%

“…Adapted from Jiang et al 2 with permission global OEF of 31.8 ± 4.1%, which was similar to the adult OEF level. 204 There is currently a paucity of human studies on age-related OEF changes in children of 1 to 18 years of age. A previous 15 O-PET study found that OEF values in children were within the range of adult values regardless of the child's age.…”

Section: Oef Across the Human Lifespanmentioning

confidence: 99%

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Cerebral oxygen extraction fractionMRI: Techniques and applications

Jiang

2022

Magnetic Resonance in Med

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The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow and the oxygen extraction fraction (OEF). Therefore, OEF is a key physiological parameter of the brain's function and metabolism.OEF has been suggested to be a useful biomarker in a number of brain diseases.With recent advances in MRI techniques, several MRI-based methods have been developed to measure OEF in the human brain. These MRI OEF techniques are based on the T 2 of blood, the blood signal phase, the magnetic susceptibility of blood-containing voxels, the effect of deoxyhemoglobin on signal behavior in extravascular tissue, and the calibration of the BOLD signal using gas inhalation.Compared to 15 O PET, which is considered the "gold standard" for OEF measurement, MRI-based techniques are non-invasive, radiation-free, and are more widely available. This article provides a review of these emerging MRI-based OEF techniques. We first briefly introduce the role of OEF in brain oxygen homeostasis. We then review the methodological aspects of different categories of MRI OEF techniques, including their signal mechanisms, acquisition methods, and data analyses. The strengths and limitations of the techniques are discussed.Finally, we review key applications of these techniques in physiological and pathological conditions.

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“…The image quality challenge in advanced ioMRI acquisition with two RF coils arises from the limited scanning time during surgery, the relatively low signal‐to‐noise ratio (SNR) of advanced sequences, 4,5,15 and the restricted applicability of acceleration techniques, such as parallel imaging (e.g., SENSE) or Compressed Sensing, with a limited number of RF coils. Additional RF coils could impact image quality as they theoretically increase the geometry ( g ) factor and, consequently, SENSE's undersampling capabilities 16 .…”

Section: Introductionmentioning

confidence: 99%

Improving advanced intraoperative MRI methods during pediatric neurosurgery

Jellema,

Mannsdörfer,

Visser

et al. 2024

NMR in Biomedicine

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Advanced intraoperative MR images (ioMRI) acquired during the resection of pediatric brain tumors could offer additional physiological information to preserve healthy tissue. With this work, we aimed to develop a protocol for ioMRI with increased sensitivity for arterial spin labeling (ASL) and diffusion MRI (dMRI), optimized for patient positioning regularly used in the pediatric neurosurgery setting. For ethical reasons, ASL images were acquired in healthy adult subjects that were imaged in the prone and supine position. After this, the ASL cerebral blood flow (CBF) was quantified and compared between both positions. To evaluate the impact of the RF coils setups on image quality, we compared different setups (two vs. four RF coils) by looking at T1‐weighted (T1w) signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio (CNR), as well as undertaking a qualitative evaluation of T1w, T2w, ASL, and dMR images. Mean ASL CBF did not differ between the surgical prone and supine positions in any of the investigated regions of interest or the whole brain. T1w SNR (gray matter: p = 0.016, 34% increase; white matter: p = 0.016, 32% increase) and CNR were higher (p = 0.016) in the four versus two RF coils setups (18.0 ± 1.8 vs. 13.9 ± 1.8). Qualitative evaluation of T1w, T2w, ASL, and dMR images resulted in acceptable to good image quality and did not differ statistically significantly between setups. Only the nonweighted diffusion image maps and corticospinal tract reconstructions yielded higher image quality and reduced susceptibility artifacts with four RF coils. Advanced ioMRI metrics were more precise with four RF coils as the standard deviation decreased. Taken together, we have investigated the practical use of advanced ioMRI during pediatric neurosurgery. We conclude that ASL CBF quantification in the surgical prone position is valid and that ASL and dMRI acquisition with two RF coils can be performed adequately for clinical use. With four versus two RF coils, the SNR of the images increases, and the sensitivity to artifacts reduces.

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Characterization of MRI techniques to assess neonatal brain oxygenation and blood flow

Cited by 6 publications

References 34 publications

Postnatal cerebral hemodynamics in infants with severe congenital heart disease: a scoping review

Postnatal cerebral hemodynamics in infants with severe congenital heart disease: a scoping review

Cerebral oxygen extraction fractionMRI: Techniques and applications

Improving advanced intraoperative MRI methods during pediatric neurosurgery

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