Characterization of Muscle Weakness Due to Myasthenia Gravis Using Shear Wave Elastography

Zimmer, Manuela; Kleiser, Benedict; Marquetand, Justus; Ateş, Filiz

doi:10.3390/diagnostics13061108

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…In recent years, it has been shown that imaging technologies can play a major role in the diagnosis of myopathies [ 17 , 52 , 53 , 54 , 55 ]. B-mode ultrasonography can be used to evaluate muscle atrophy and decreased muscle size [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Ultrasound Shear Wave Elastography for Detection of Quadriceps Contracture in Immobilized Rats

Suwankanit,

Shimizu,

Suzuki

et al. 2023

Animals

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Quadriceps contracture is an abnormal pathological shortening of the muscle–tendon unit. To improve the prognosis of quadriceps contracture, improvement of its diagnostic method is needed. In this study, we evaluated the diagnostic utility of ultrasound shear wave elastography in a rat model of quadriceps contracture induced by immobilization. Fifty Wistar rats were randomly divided into control and immobilization groups. During up to 4 weeks of joint immobilization, the quadriceps elastic modulus, muscle hardness, creatinine phosphokinase levels, joint range of motion, histopathologic parameters, and levels of fibrosis-associated mRNA expression were measured every week in the immobilization and control groups and compared. In the immobilization group, the elastic modulus gradually but significantly increased (p < 0.05) throughout the immobilization period. However, muscle hardness and serum creatinine phosphokinase levels only increased at 1 and 2 weeks after the start of immobilization, respectively. Muscle atrophy and shortening progressed throughout the immobilization group. Collagen type I and III, α-SMA protein, and mRNA expression of IL-1β and TGF-β1 significantly increased (p < 0.05) throughout in the immobilization group. Ultrasound shear wave elastography is the most useful method for clinical assessment of muscle contracture.

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Section: Discussionmentioning

confidence: 99%

Usefulness of Ultrasound Shear Wave Elastography for Detection of Quadriceps Contracture in Immobilized Rats

Suwankanit,

Shimizu,

Suzuki

et al. 2023

Animals

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“…In vivo characterization of skeletal muscles is crucial for understanding musculoskeletal diseases and improving treatment strategies. For this, the non-invasive ultrasound shear wave elastography (SWE) has recently been shown to represent both passive [1] , [2] , [3] , [4] and active muscle mechanics [5] , [6] , [7] , [8] in healthy cohorts and several studies have demonstrated the clinical potential for SWE, for example for patients diagnosed with myotonia [9] , Duchenne muscular dystrophy [10] , myasthenia gravis [11] or Parkinson [12] . However, applying SWE on skeletal muscles poses challenges due to the muscles' complex and heterogeneous architecture.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Assessment of Shear Wave Propagation in Pennate Muscles Using an Automatic Ultrasound Probe Alignment System

Zimmer,

Bunz,

Ehring

et al. 2023

IEEE Open J. Eng. Med. Biol.

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Goal: Skeletal muscle mechanics can be assessed in vivo using shear wave elastography. However, the impact of pennation angle on shear wave velocity (SWV) remains unclear. This study aims to quantify the effect by automatically aligning the ultrasound probe with muscle fiber orientation. Methods: We propose an automatic ultrasound probe alignment system and compare it to manual and no alignment. SWV of the gastrocnemius medialis muscle of ten volunteers was measured during rest and isometric contractions. Results: The SWV was different between the conditions ( p = 0.008). The highest SWV was obtained during the automatic alignment and differences between the conditions were most pronounced during high-level contractions. The automatic system yielded more accurate alignment compared to a manual operator ( p = 0.05). Conclusions: The present study indicates that pennation angle affects SWV, hence muscle fiber orientation must be considered to reliably interpret SWV. Using automatic alignment systems allows for more accurate alignment, improving the methodology of ultrasound elastography in skeletal muscles.

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Experiments meet simulations: Understanding skeletal muscle mechanics to address clinical problems

Ateş,

Röhrle

2024

GAMM-Mitteilungen

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This article aims to present some novel experimental approaches and computational methods providing detailed insights into the mechanical behavior of skeletal muscles relevant to clinical problems associated with managing and treating musculoskeletal diseases. The mechanical characterization of skeletal muscles in vivo is crucial for better understanding of, prevention of, or intervention in movement alterations due to exercise, aging, or pathologies related to neuromuscular diseases. To achieve this, we suggest an intraoperative experimental method including direct measurements of human muscle forces supported by computational methodologies. A set of intraoperative experiments indicated the major role of extracellular matrix (ECM) in spastic cerebral palsy. The force data linked to joint function are invaluable and irreplaceable for evaluating individual muscles however, they are not feasible in many situations. Three‐dimensional, continuum‐mechanical models provide a way to predict the exerted muscle forces. To obtain, however, realistic predictions, it is important to investigate the muscle not by itself, but embedded within the respective musculoskeletal system, for example, a 6‐muscle upper arm model, and the ability to obtain non‐invasively, or at least, minimally invasively material parameters for continuum‐mechanical skeletal muscle models, for example, by presently proposed homogenization methodologies. Botulinum toxin administration as a treatment option for spasticity is exemplified by combining experiments with modeling to find out the mechanical outcomes of altered ECM and the controversial effects of the toxin. The potentials and limitations of both experimental and modeling approaches and how they need each other are discussed.

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Characterization of Muscle Weakness Due to Myasthenia Gravis Using Shear Wave Elastography

Cited by 4 publications

References 40 publications

Usefulness of Ultrasound Shear Wave Elastography for Detection of Quadriceps Contracture in Immobilized Rats

Usefulness of Ultrasound Shear Wave Elastography for Detection of Quadriceps Contracture in Immobilized Rats

In Vivo Assessment of Shear Wave Propagation in Pennate Muscles Using an Automatic Ultrasound Probe Alignment System

Experiments meet simulations: Understanding skeletal muscle mechanics to address clinical problems

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