Characterization of Nanomaterials for Toxicological Evaluation

Powers, Kevin; Palazuelos, Maria; Brown, Scott C.; Roberts, Stephen M.

doi:10.1002/9780470747803.ch1

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…Additionally, the disposition and translocation of nanomaterials in the organism may be influenced by their shape, accompanying size and state of agglomeration (Powers et al, 2009). One example is an in vitro study of silica NPs demonstrating shape-driven agglomeration as a potential trigger in the pulmonary pathogenesis (Brown et al, 2007).…”

Section: Overview Of Physicochemical Characteristicsmentioning

confidence: 99%

“…Similarly, plate-shaped silver NPs were more hazardous than spherical, rod-shaped or wire shaped silver nanoparticles when tested against Escherichia coli and zebrafish embryos (George et al, 2012; Pal et al, 2007). Furthermore, recent studies demonstrated an asbestos-like pathogenic response when carbon nanotubes of length greater than 20 µm were delivered into the abdominal cavity of mice (Kostarelos, 2008; Poland et al, 2008; Powers et al, 2009; Takagi et al, 2008). …”

Section: Overview Of Physicochemical Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Techniques for physicochemical characterization of nanomaterials

Lin

Wang

et al. 2014

Biotechnology Advances

565

297

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Advances in nanotechnology have opened up a new era of diagnosis, prevention and treatment of diseases and traumatic injuries. Nanomaterials, including those with potential for clinical applications, possess novel physicochemical properties that have an impact on their physiological interactions, from the molecular level to the systemic level. There is a lack of standardized methodologies or regulatory protocols for detection or characterization of nanomaterials. This review summarizes the techniques that are commonly used to study the size, shape, surface properties, composition, purity and stability of nanomaterials, along with their advantages and disadvantages. At present there are no FDA guidelines that have been developed specifically for nanomaterial based formulations for diagnostic or therapeutic use. There is an urgent need for standardized protocols and procedures for the characterization of nanoparticles, especially those that are intended for use as theranostics.

show abstract

Section: Overview Of Physicochemical Characteristicsmentioning

confidence: 99%

Section: Overview Of Physicochemical Characteristicsmentioning

confidence: 99%

Techniques for physicochemical characterization of nanomaterials

Lin

Wang

et al. 2014

Biotechnology Advances

565

297

View full text Add to dashboard Cite

show abstract

“…Concern about the toxicity of nanomaterials lies primarily in production and commercialization on such a large scale as at present. Thus, the risk of these compounds reaching the different environmental compartments (atmosphere, water, and soil), becoming bioavailable, is very large [3,17].…”

Section: Toxicological Aspects Of Nanomaterialsmentioning

confidence: 99%

How to Assess Nanomaterial Toxicity? An Environmental and Human Health Approach

Roberto¹,

Christofoletti²

2020

Nanomaterials - Toxicity, Human Health and Environment

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Nanomaterials had been used because of the properties they exert in such scale (<100 nm), and they have been used in a wide variety of products like paints, electronics, fabrics, and also personal care products. Recent manuscripts available in the literature demonstrate the potential benefits of nanotechnology with these products. However, when released in the environment or when in contact with the human body, it is hard to track their final destination and their influence over the living beings. So, since nanomaterials were considered an important technology, a concern about its risks also started. Due to the variety of sizes, physicochemical properties, and uses, many researchers are aiming to assess the possible toxicity of this class of particles. Because of that, the chapter objective is to gather which assay, performed in vivo and in vitro, is the most frequently used and recommended to measure nanomaterial toxicity. Also, it is important to know which is the most suitable test to evaluate the toxicity over the environment, through direct effect and after biodegradation, and also related to human health. This chapter presents a concise review about the accepted methods to assess nanomaterial toxicity and also discuss about the need for regulamentation.

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Nuclear Magnetic Resonance Spectroscopy in Nanomedicine

Lin

2014

Progress in Optical Science and Photonics

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Characterization of Nanomaterials for Toxicological Evaluation

Cited by 6 publications

References 35 publications

Techniques for physicochemical characterization of nanomaterials

Techniques for physicochemical characterization of nanomaterials

How to Assess Nanomaterial Toxicity? An Environmental and Human Health Approach

Nuclear Magnetic Resonance Spectroscopy in Nanomedicine

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