Characterization of Nanoparticles by FTIR and FTIR-Microscopy

Eid, May

doi:10.1007/978-981-16-8698-6_89

Cited by 19 publications

(13 citation statements)

References 28 publications

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“…FT-IR spectroscopy was chosen as the technique of choice for precise deconvolution of chemical bond transformations toward the formation of CTT nanosystem, owing to its robustness in bond characterization compared to other techniques. 35,36 Importantly, this allowed us to discern the chemistry involved in the formulation of the nanosystem and ultimately verify our fabrication methodology. Accordingly, the spectra from the FT-IR spectroscopy analysis are presented in Figure 3a−e.…”

Section: ■ Results and Discussionmentioning

confidence: 92%

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model

Ngema,

Adeyemi,

Marimuthu

et al. 2023

ACS Omega

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The design of targeted antiangiogenic nanovectors for the delivery of anticancer drugs presents a viable approach for effective management of nonsmall-cell lung carcinoma (NSCLC). Herein, we report on the fabrication of a targeted delivery nanosystem for paclitaxel (PTX) functionalized with a short antimatrix metalloproteinase 2 (MMP-2) CTT peptide for selective MMP-2 targeting and effective antitumor activity in NSCLC. The fabrication of the targeted nanosystem (CLA-coated PTX-SPIONs@CTT) involved coating of superparamagnetic iron-oxide nanoparticles (SPIONs) with conjugated linoleic acid (CLA) via chemisorption, onto which PTX was adsorbed, and subsequent surface functionalization with carboxylic acid groups for conjugation of the CTT peptide. CLA-coated PTX SPIONs@CTT had a mean particle size of 99.4 nm and a PTX loading efficiency of ∼98.5%. The nanosystem exhibited a site-specific in vitro PTX release and a marked antiproliferative action on lung adenocarcinoma cells. The CTT-functionalized nanosystem significantly inhibited MMP-2 secretion by almost 70% from endothelial cells, indicating specific anti-MMP-2 activity. Treatment of tumor-bearing mice with subcutaneous injection of the CTT-functionalized nanosystem resulted in 69.7% tumor inhibition rate, and the administration of the nanosystem subcutaneously prolonged the half-life of PTX and circulation time in vivo. As such, CLA-coated PTX-SPIONs@CTT presents with potential for application as a targeted nanomedicine in NSCLC management.

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Section: ■ Results and Discussionmentioning

confidence: 92%

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model

Ngema,

Adeyemi,

Marimuthu

et al. 2023

ACS Omega

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“…FTIR is a commonly used technique for obtaining material- specific IR spectra, and it is useful for identifying potential interactions among molecules. FTIR analysis is fast, sensitive, and precise compared to other IR methods, making it an ideal method for analysing small samples ( Eid, 2022 ). In this study, IR spectra of the pure drugs (SORA and PIP), PLGA, the physical mixture of SORA, PIP, and PLGA, freeze-dried B-PNPs, and SP-PNPs were generated as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line

Alhudaithi,

Abul Kalam,

Binobaid

et al. 2024

Saudi Pharmaceutical Journal

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“…The main challenges in the novel therapeutic approaches to cancer are the drug resistance of cancer cells, determined by the reduced retention interval, low permeability, the triggering of inactivation by the immune system, and the lack of specificity [ 89 , 90 ].…”

Section: Resultsmentioning

confidence: 99%

“…The use of FTIR is one of the most common analytical techniques, and it is considered fundamental in the analysis of complex carrier systems due to its features (sensitivity, flexibility, robustness, and specificity), allowing the investigation of interactions between biomolecules and mineral components [ 90 ].…”

Section: Resultsmentioning

confidence: 99%

Romanian Wild-Growing Armoracia rusticana L.—Untargeted Low-Molecular Metabolomic Approach to a Potential Antitumoral Phyto-Carrier System Based on Kaolinite

Segneanu,

Vlase,

Chirigiu

et al. 2023

Antioxidants

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Horseradish is a globally well-known and appreciated medicinal and aromatic plant. The health benefits of this plant have been appreciated in traditional European medicine since ancient times. Various studies have investigated the remarkable phytotherapeutic properties of horseradish and its aromatic profile. However, relatively few studies have been conducted on Romanian horseradish, and they mainly refer to the ethnomedicinal or dietary uses of the plant. This study reports the first complete low-molecular-weight metabolite profile of Romanian wild-grown horseradish. A total of ninety metabolites were identified in mass spectra (MS)-positive mode from nine secondary metabolite categories (glucosilates, fatty acids, isothiocyanates, amino acids, phenolic acids, flavonoids, terpenoids, coumarins, and miscellaneous). In addition, the biological activity of each class of phytoconstituents was discussed. Furthermore, the development of a simple target phyto-carrier system that collectively exploits the bioactive properties of horseradish and kaolinite is reported. An extensive characterization (FT-IR, XRD, DLS, SEM, EDS, and zeta potential) was performed to investigate the morpho-structural properties of this new phyto-carrier system. The antioxidant activity was evaluated using a combination of three in vitro, non-competitive methods (total phenolic assay, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, and phosphomolybdate (total antioxidant capacity)). The antioxidant assessment indicated the stronger antioxidant properties of the new phyto-carrier system compared with its components (horseradish and kaolinite). The collective results are relevant to the theoretical development of novel antioxidant agent fields with potential applications on antitumoral therapeutic platforms.

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Characterization of Nanoparticles by FTIR and FTIR-Microscopy

Cited by 19 publications

References 28 publications

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model

Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line

Romanian Wild-Growing Armoracia rusticana L.—Untargeted Low-Molecular Metabolomic Approach to a Potential Antitumoral Phyto-Carrier System Based on Kaolinite

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