Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

DOĞAN, Murat; SİVAS CUMHURİYET ÜNİVERSİTESİ; TAŞKIN, Duygu; SAĞLIK BİLİMLERİ ÜNİVERSİTESİ; PR., ERMANOĞLU, Mizgin; MARMARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK; ARABACİ, Turan; İNÖNÜ ÜNİVERSİTESİ

doi:10.17776/csj.1056496

Cumhuriyet Science Journal

2022

DOI: 10.17776/csj.1056496

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Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Murat; SİVAS CUMHURİYET ÜNİVERSİTESİ DOĞAN

Duygu; SAĞLIK BİLİMLERİ ÜNİVERSİTESİ TAŞKIN

ERMANOĞLU, Mizgin; MARMARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK PR.

et al.

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2024

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Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)

Boran Gülen,

Saraç,

Uğur

2024

International Journal of Secondary Metabolite

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This study aims to determine the anti-aging effects of Achillea phrygia, an endemic plant, by evaluating its sun protection factor (SPF) level, antioxidant activity, total phenolic content, extracellular matrix-degrading enzymes (ECM) inhibition, genotoxic/anti-genotoxic, and cytotoxic activities. The SPF level was assessed using an in vitro quantitative method, while antioxidant capacity was determined through DPPH, β-carotene, and hydroxyl-radical (H2O2) scavenging assays. The total phenolic content was quantitatively conducted using the Folin Ciocalteu reagent. The inhibition of ECM-degrading enzymes was determined using matrix metalloproteinase-1 (MMP-1), hyaluronidase, and elastase enzymes. Genotoxic/anti-genotoxic properties were assessed using the AMES Salmonella/microsome assay, and cytotoxicity effects were assessed through the MTT assay. The results indicated that A. phrygia showed moderate SPF activity (SPF = 4.013) and exhibited IC50 values of 0.183 ± 0.03, 0.079 ± 0.51, and 1.18 ± 0.35 mg/mL for DPPH, β-carotene, and hydroxyl-radicals, respectively. The total phenolic content was measured to be 23.56 ± 1.42 mg GAE/g dry extract. Furthermore, the extract demonstrated inhibition of MMP-1 (47.98%) and elastase (39.2%) activities. Importantly, it did not induce DNA damage and showed antigenotoxic activity ranging from 10% to 65.6%. The cytotoxicity assay revealed an IC50 value of 42.41±4.05 µg/mL. These findings suggest that A. phrygia could be utilized as a cosmetic ingredient in skincare products due to its ability to protect against UV radiation, exhibit antioxidant properties, prevent extracellular matrix degradation, and inhibit DNA damage.

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Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)

Boran Gülen,

Saraç,

Uğur

2024

International Journal of Secondary Metabolite

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Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Abstract: History

Cited by 1 publication

References 19 publications

Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)

Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)

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