In this study, two different compositions of submicrometre copper and chromium powders were mixed and the Cr50Cu50 alloys were fabricated via the powder metallurgy technique. The research imposed various hot pressing pressures, while the temperature was maintained at 1050°C for 1 h, respectively. The experimental results showed that the Saint Venant's effect obviously appeared in 1050°C, 48 MPa, 1 h hot pressing Cr50Cu50 alloys, which led to differences in the surface and internal hardness of the specimens. As a result, the optimal parameters of hot pressing of Cr50Cu50 alloys were 1050°C, 36 MPa for 1 h possessing the highest transverse rupture strength value (921.69 MPa). Moreover, the surface hardness increased to HV 0.2 221.78 (HRB 95.4), the relative density reached 97.15% and apparent porosity decreased to 0.10%, respectively. Furthermore, the resistivity decreased to 5.28 × 10 −6 Ω cm, and ICAS was enhanced to 32.65% after the optimal procedure.