1999
DOI: 10.1002/(sici)1097-0045(19990915)41:1<39::aid-pros6>3.0.co;2-e
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Characterization of nerve growth factor precursor protein expression by human prostate stromal cells: A role in selective neurotrophin stimulation of prostate epithelial cell growth

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Cited by 43 publications
(32 citation statements)
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“…NGF-β stimulates the growth of prostate epithelial cells, which suggests the paracrine regulation of prostate cell growth by NGF-β or other neurotrophins. In contrast to benign prostate epithelial cells, p75NTR expression is decreased in cancer cells (13,14). A dramatic increase in p75 immunoreactivity has been observed in the stroma and this correlates with an increase in malignancy (16).…”
Section: Introductionmentioning
confidence: 91%
See 1 more Smart Citation
“…NGF-β stimulates the growth of prostate epithelial cells, which suggests the paracrine regulation of prostate cell growth by NGF-β or other neurotrophins. In contrast to benign prostate epithelial cells, p75NTR expression is decreased in cancer cells (13,14). A dramatic increase in p75 immunoreactivity has been observed in the stroma and this correlates with an increase in malignancy (16).…”
Section: Introductionmentioning
confidence: 91%
“…Neurotrophin growth factor [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)] binding activates tyrosine kinase receptors encoded by the Trk family (Trk A, Trk B and Trk C), and the low-affinity receptor p75NTR. In the normal prostate, p75NTR and Trk A are found on benign prostate epithelial cells, whereas NGF-β is expressed by adjacent stromal cells (13)(14)(15)(16). NGF-β stimulates the growth of prostate epithelial cells, which suggests the paracrine regulation of prostate cell growth by NGF-β or other neurotrophins.…”
Section: Introductionmentioning
confidence: 99%
“…33 Secretions from prostate stromal cells are able to induce chemotaxis and chemokinesis of TSU-pr1, PC-3 and DU-145 prostate tumor cell lines in a modified Boyden chamber assay. 34 These secretions contain many proteins, including an NGF precursor, 35 which upon immunoprecipitation inhibits chemotaxis of the tumor cells. 34 Indeed, recombinant NGF also increases the invasive capability of prostate cancer cells in vitro.…”
Section: Increased P75 Ntr Expression Suppresses Ngf-stimulated Satelmentioning
confidence: 99%
“…sympathetic neurons (16) and dorsal root ganglia (17)) but by many different tissues outside the nervous system. These include cells of the ovary (18 -20), bone marrow (21), hair follicles (22), liver (23), urinary bladder (24), retina (25), prostate cells (26), oral mucosal keratinocytes (27), and spermatids (28). NGF is also produced and released by cells of the immune system, namely mast cells, which also respond to NGF (29,30).…”
mentioning
confidence: 88%